{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:53:46Z","timestamp":1791381226099,"version":"4.3.3"},"reference-count":53,"publisher":"American Diabetes Association","issue":"2","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/501100014636","name":"Minist\u00e8re de l\u2019Enseignement Sup\u00e9rieur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014636","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Soci\u00e9t\u00e9 Francophone pour le Diab\u00e8te [SFD]","award":["RAK18021DDA"],"award-info":[{"award-number":["RAK18021DDA"]}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019125","name":"Sorbonne Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale [FRM]","doi-asserted-by":"crossref","award":["EQU201903007868"],"award-info":[{"award-number":["EQU201903007868"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n                  <jats:p>In humans, glucocorticoids (GCs) are commonly prescribed because of their anti-inflammatory and immunosuppressive properties. However, high doses of GCs often lead to side effects, including diabetes and lipodystrophy. We recently reported that adipocyte glucocorticoid receptor (GR)\u2013deficient (AdipoGR-KO) mice under corticosterone (CORT) treatment exhibited a massive adipose tissue (AT) expansion associated with a paradoxical improvement of metabolic health compared with control mice. However, whether GR may control adipose development remains unclear. Here, we show a specific induction of hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) and proangiogenic vascular endothelial growth factor A (VEGFA) expression in GR-deficient adipocytes of AdipoGR-KO mice compared with control mice, together with an increased adipose vascular network, as assessed by three-dimensional imaging. GR activation reduced HIF-1\u03b1 recruitment to the Vegfa promoter resulting from Hif-1\u03b1 downregulation at the transcriptional and posttranslational levels. Importantly, in CORT-treated AdipoGR-KO mice, the blockade of VEGFA by a soluble decoy receptor prevented AT expansion and the healthy metabolic phenotype. Finally, in subcutaneous AT from patients with Cushing syndrome, higher VEGFA expression was associated with a better metabolic profile. Collectively, these results highlight that adipocyte GR negatively controls AT expansion and metabolic health through the downregulation of the major angiogenic effector VEGFA and inhibition of vascular network development.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Article Highlights<\/jats:title>\n               <\/jats:sec>","DOI":"10.2337\/db23-0165","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T22:14:17Z","timestamp":1700000057000},"page":"211-224","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":16,"title":["Adipocyte Glucocorticoid Receptor Activation With High Glucocorticoid Doses Impairs Healthy Adipose Tissue Expansion by Repressing Angiogenesis"],"prefix":"10.2337","volume":"73","author":[{"given":"Anna","family":"Vali","sequence":"first","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lo\u00efse","family":"Dalle","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alya","family":"Loubaresse","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Gilleron","sequence":"additional","affiliation":[{"name":"3Universit\u00e9 C\u00f4te d\u2019Azur, INSERM, C3M, Team Cellular and Molecular Pathophysiology of Obesity, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Havis","sequence":"additional","affiliation":[{"name":"4Sorbonne Universit\u00e9, CNRS, INSERM, Laboratoire de Biologie du D\u00e9veloppement, Institut Biologie Paris Seine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Garcia","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Beaup\u00e8re","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mentine","family":"Denis","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Roblot","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Poussin","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Ledent","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4317-6714","authenticated-orcid":false,"given":"Benjamin","family":"Bouillet","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Cormont","sequence":"additional","affiliation":[{"name":"3Universit\u00e9 C\u00f4te d\u2019Azur, INSERM, C3M, Team Cellular and Molecular Pathophysiology of Obesity, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Tanti","sequence":"additional","affiliation":[{"name":"3Universit\u00e9 C\u00f4te d\u2019Azur, INSERM, C3M, Team Cellular and Molecular Pathophysiology of Obesity, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Capeau","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Vatier","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"},{"name":"5Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Assistance Publique des H\u00f4pitaux de Paris, H\u00f4pital Saint-Antoine, Service Endocrinologie, CRMR PRISIS, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"F\u00e8ve","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"},{"name":"5Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Assistance Publique des H\u00f4pitaux de Paris, H\u00f4pital Saint-Antoine, Service Endocrinologie, CRMR PRISIS, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Grosfeld","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-2267","authenticated-orcid":false,"given":"Marthe","family":"Moldes","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris, France"},{"name":"2Sorbonne Universit\u00e9, INSERM, Institute of CardioMetabolism and Nutrition, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"2024011919574908200_B1","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1007\/s40265-014-0282-9","article-title":"Systemic glucocorticoid therapy: a review of its metabolic and cardiovascular adverse 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