{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:56:23Z","timestamp":1790283383469,"version":"4.1.0"},"reference-count":56,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK058404"],"award-info":[{"award-number":["P30 DK058404"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK20593"],"award-info":[{"award-number":["P30 DK20593"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32 DK007061"],"award-info":[{"award-number":["T32 DK007061"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T35 DK007383"],"award-info":[{"award-number":["T35 DK007383"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA068485"],"award-info":[{"award-number":["P30 CA068485"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["T32 AR059039"],"award-info":[{"award-number":["T32 AR059039"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022690","name":"JDRF","doi-asserted-by":"publisher","award":["2-SRA-2023-1453-S-B"],"award-info":[{"award-number":["2-SRA-2023-1453-S-B"]}],"id":[{"id":"10.13039\/100022690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022690","name":"JDRF","doi-asserted-by":"publisher","award":["3-PDF-2024-1495-A-N"],"award-info":[{"award-number":["3-PDF-2024-1495-A-N"]}],"id":[{"id":"10.13039\/100022690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12 HD043483"],"award-info":[{"award-number":["K12 HD043483"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research","doi-asserted-by":"publisher","award":["R01 AI051448"],"award-info":[{"award-number":["R01 AI051448"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>High-affinity islet autoantibodies predict type 1 diabetes in mice and humans and implicate germinal centers (GCs) in disease pathogenesis. T follicular helper (Tfh) cells are increased in individuals with type 1 diabetes and alterations in Tfh-like cells in the peripheral blood predicted individual responses to abatacept. Tfh cells support GC responses and depend on the transcriptional repressor BCL6 for their maturation. Therefore, we hypothesized that CD4-driven deletion of Bcl6 would disrupt essential T- and B-cell interactions in GCs to prevent type 1 diabetes. To test this hypothesis, we generated Bcl6fl\/fl-CD4.Cre.NOD mice and found they were completely protected against diabetes. Insulitis severity and tertiary lymphoid structure organization were preserved in the pancreas of Bcl6fl\/fl-CD4.Cre.NOD mice, which did not show decreases in CD4+, CD8+, and B-cell numbers in the pancreas and draining lymph nodes, relative to control Bcl6fl\/fl.NOD mice. CD4-driven loss of functional BCL6 resulted in significantly reduced GC B-cell and Tfh-cell numbers in the pancreatic lymph nodes and pancreas at late prediabetic intervals. Spontaneous anti-insulin autoantibody was blunted in Bcl6fl\/fl-CD4.Cre.NOD mice. These data highlight BCL6 as a novel therapeutic target in type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Article Highlights<\/jats:title>\n                    <jats:p>Germinal center B cells and CD4+ T follicular helper cells are implicated in the pathogenesis of type 1 diabetes and depend upon the transcriptional repressor BCL6 for their maturation. This study tests the dependence of type 1 diabetes development on BCL6 expression in CD4+ cells. Data presented here show that CD4-driven loss of Bcl6 blocks germinal center formation, spontaneous insulin autoantibody production, and type 1 diabetes in nonobese diabetic mice, despite normal tertiary lymphoid structure formation in pancreatic islets. This study highlights BCL6 as a potential immunomodulatory target in type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/db23-0709","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T16:37:32Z","timestamp":1731947852000},"page":"921-932","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":8,"title":["Type 1 Diabetes Depends on CD4-Driven Expression of the Transcriptional Repressor\n                    <i>Bcl6<\/i>"],"prefix":"10.2337","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8592-4015","authenticated-orcid":false,"given":"Dudley H.","family":"McNitt","sequence":"first","affiliation":[{"name":"1Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Williams","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Santitoro","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Kim","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2098-6458","authenticated-orcid":false,"given":"James W.","family":"Thomas","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN"},{"name":"2Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7575-6943","authenticated-orcid":false,"given":"Rachel H.","family":"Bonami","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN"},{"name":"2Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN"},{"name":"3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN"},{"name":"4Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"2025052014515990500_B1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/biomedicines9010042","article-title":"B quiet: autoantigen-specific strategies to silence raucous B lymphocytes and halt cross-talk with T cells in type 1 diabetes","volume":"9","author":"Felton","year":"2021","journal-title":"Biomedicines"},{"key":"2025052014515990500_B2","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1084\/jem.184.5.2049","article-title":"B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new \u201cspeed congenic\u201d stock of NOD.Ig mu null mice","volume":"184","author":"Serreze","year":"1996","journal-title":"J Exp Med"},{"key":"2025052014515990500_B3","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1056\/NEJMoa0904452","article-title":"Rituximab, B-lymphocyte depletion, and preservation of beta-cell function","volume":"361","author":"Pescovitz","year":"2009","journal-title":"N Engl J Med"},{"key":"2025052014515990500_B4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0140-6736(11)60886-6","article-title":"Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial","volume":"378","author":"Orban","year":"2011","journal-title":"Lancet"},{"key":"2025052014515990500_B5","article-title":"FDA approves first drug that can delay onset of type 1 diabetes","author":"U.S. Food and Drug Administration","year":"2023"},{"key":"2025052014515990500_B6","doi-asserted-by":"crossref","first-page":"1295\u20131302.e1295","DOI":"10.1016\/j.jaci.2011.08.008","article-title":"Effect of rituximab on human in\u00a0vivo antibody immune responses","volume":"128","author":"Pescovitz","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"2025052014515990500_B7","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1172\/JCI23961","article-title":"TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs","volume":"115","author":"Bisikirska","year":"2005","journal-title":"J Clin Invest"},{"key":"2025052014515990500_B8","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.2337\/dc15-1429","article-title":"Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report","volume":"38","author":"Wherrett","year":"2015","journal-title":"Diabetes Care"},{"key":"2025052014515990500_B9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","article-title":"Follicular helper CD4 T cells (TFH)","volume":"29","author":"Crotty","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"2025052014515990500_B10","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00125-015-3509-8","article-title":"IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients","volume":"58","author":"Ferreira","year":"2015","journal-title":"Diabetologia"},{"key":"2025052014515990500_B11","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1172\/JCI76238","article-title":"Follicular helper T cell signature in type 1 diabetes","volume":"125","author":"Kenefeck","year":"2015","journal-title":"J Clin Invest"},{"key":"2025052014515990500_B12","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/s41590-020-0744-z","article-title":"Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes","volume":"21","author":"Edner","year":"2020","journal-title":"Nat Immunol"},{"key":"2025052014515990500_B13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41435-018-0032-1","article-title":"Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes","volume":"20","author":"Linsley","year":"2019","journal-title":"Genes Immun"},{"key":"2025052014515990500_B14","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.immuni.2019.04.011","article-title":"T follicular helper cell biology: a decade of discovery and diseases","volume":"50","author":"Crotty","year":"2019","journal-title":"Immunity"},{"key":"2025052014515990500_B15","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.immuni.2011.01.021","article-title":"A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity","volume":"34","author":"McGuire","year":"2011","journal-title":"Immunity"},{"key":"2025052014515990500_B16","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.it.2021.02.002","article-title":"Bcl6-mediated transcriptional regulation of follicular helper T cells (TFH)","volume":"42","author":"Choi","year":"2021","journal-title":"Trends Immunol"},{"key":"2025052014515990500_B17","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41423-019-0220-6","article-title":"Helper T cell differentiation","volume":"16","author":"Saravia","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"2025052014515990500_B18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1126\/science.276.5312.589","article-title":"Control of inflammation, cytokine expression, and germinal center formation by BCL-6","volume":"276","author":"Dent","year":"1997","journal-title":"Science"},{"key":"2025052014515990500_B19","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.4049\/jimmunol.1300378","article-title":"Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model","volume":"191","author":"Hollister","year":"2013","journal-title":"J Immunol"},{"key":"2025052014515990500_B20","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/ni.2543","article-title":"Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms","volume":"14","author":"Huang","year":"2013","journal-title":"Nat Immunol"},{"key":"2025052014515990500_B21","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1172\/JCI85795","article-title":"Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma","volume":"126","author":"Cardenas","year":"2016","journal-title":"J Clin Invest"},{"key":"2025052014515990500_B22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1182\/blood-2018-03-839993","article-title":"Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease","volume":"133","author":"Paz","year":"2019","journal-title":"Blood"},{"key":"2025052014515990500_B23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/jmp.12438","article-title":"BCL6 BTB-specific inhibition via FX1 treatment reduces Tfh cells and reverses lymphoid follicle hyperplasia in Indian rhesus macaque (Macaca mulatta)","volume":"49","author":"Cai","year":"2020","journal-title":"J Med Primatol"},{"key":"2025052014515990500_B24","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.4049\/jimmunol.0900367","article-title":"Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene","volume":"183","author":"Kendall","year":"2009","journal-title":"J Immunol"},{"key":"2025052014515990500_B25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1074-7613(01)00227-8","article-title":"A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival","volume":"15","author":"Lee","year":"2001","journal-title":"Immunity"},{"key":"2025052014515990500_B26","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.2337\/db11-1746","article-title":"Autoantigen-specific B-cell depletion overcomes failed immune tolerance in type 1 diabetes","volume":"61","author":"Henry","year":"2012","journal-title":"Diabetes"},{"key":"2025052014515990500_B27","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.4049\/jimmunol.166.5.3194","article-title":"Anergy and not clonal ignorance determines the fate of B cells that recognize a physiological autoantigen","volume":"166","author":"Rojas","year":"2001","journal-title":"J Immunol"},{"key":"2025052014515990500_B28","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2337\/db16-0714","article-title":"Circulating CXCR5+PD-1+ICOS+ follicular T helper cells are increased close to the diagnosis of type 1 diabetes in children with multiple autoantibodies","volume":"66","author":"Viisanen","year":"2017","journal-title":"Diabetes"},{"key":"2025052014515990500_B29","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.4049\/jimmunol.178.9.5643","article-title":"Tertiary lymphoid structures in the pancreas promote selection of B lymphocytes in autoimmune diabetes","volume":"178","author":"Kendall","year":"2007","journal-title":"J Immunol"},{"key":"2025052014515990500_B30","doi-asserted-by":"crossref","first-page":"7712","DOI":"10.1038\/s41467-023-43427-4","article-title":"Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states","volume":"14","author":"Podest\u00e0","year":"2023","journal-title":"Nat Commun"},{"key":"2025052014515990500_B31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature12058","article-title":"Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility","volume":"496","author":"Xu","year":"2013","journal-title":"Nature"},{"key":"2025052014515990500_B32","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1073\/pnas.040556697","article-title":"Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes","volume":"97","author":"Yu","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025052014515990500_B33","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.4049\/jimmunol.1900464","article-title":"T-B lymphocyte interactions promote type 1 diabetes independently of SLAM-associated protein","volume":"205","author":"Bonami","year":"2020","journal-title":"J Immunol"},{"key":"2025052014515990500_B34","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.2426","article-title":"Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions","volume":"17","author":"Chung","year":"2011","journal-title":"Nat Med"},{"key":"2025052014515990500_B35","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.1210\/jc.2019-00093","article-title":"Follicular regulatory T cells are associated with \u03b2-cell autoimmunity and the development of type 1 diabetes","volume":"104","author":"Xu","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"2025052014515990500_B36","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.2337\/db21-0091","article-title":"Reduced follicular regulatory T cells in spleen and pancreatic lymph nodes of patients with type 1 diabetes","volume":"70","author":"Vecchione","year":"2021","journal-title":"Diabetes"},{"key":"2025052014515990500_B37","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1007\/s00125-021-05453-z","article-title":"Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes","volume":"64","author":"Korpos","year":"2021","journal-title":"Diabetologia"},{"key":"2025052014515990500_B38","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4049\/jimmunol.0903710","article-title":"CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice","volume":"185","author":"Henry","year":"2010","journal-title":"J Immunol"},{"key":"2025052014515990500_B39","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1084\/jem.20051409","article-title":"Where CD4+CD25+ T reg cells impinge on autoimmune diabetes","volume":"202","author":"Chen","year":"2005","journal-title":"J Exp Med"},{"key":"2025052014515990500_B40","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1084\/jem.20130582","article-title":"Pathogenic CD4+ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes","volume":"210","author":"Mohan","year":"2013","journal-title":"J Exp Med"},{"key":"2025052014515990500_B41","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1084\/jem.20151869","article-title":"Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites","volume":"213","author":"Wan","year":"2016","journal-title":"J Exp Med"},{"key":"2025052014515990500_B42","doi-asserted-by":"crossref","first-page":"e12943","DOI":"10.1111\/sji.12943","article-title":"B cell helper T cells and type 1 diabetes","volume":"92","author":"Vandamme","year":"2020","journal-title":"Scand J Immunol"},{"key":"2025052014515990500_B43","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aai8593","article-title":"The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness","volume":"1","author":"Wu","year":"2016","journal-title":"Sci Immunol"},{"key":"2025052014515990500_B44","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41586-021-04248-x","article-title":"An autoimmune stem-like CD8 T cell population drives type 1 diabetes","volume":"602","author":"Gearty","year":"2022","journal-title":"Nature"},{"key":"2025052014515990500_B45","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1172\/JCI19585","article-title":"Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health","volume":"113","author":"Arif","year":"2004","journal-title":"J Clin Invest"},{"key":"2025052014515990500_B46","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/dmrr.256","article-title":"Serum IFN-gamma and IL-10 levels are associated with disease progression in non-obese diabetic mice","volume":"18","author":"Schloot","year":"2002","journal-title":"Diabetes Metab Res Rev"},{"key":"2025052014515990500_B47","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/dme.13153","article-title":"\u03b2-Cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with type 1 diabetes compared with adults","volume":"34","author":"Arif","year":"2017","journal-title":"Diabet Med"},{"key":"2025052014515990500_B48","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/cei.12672","article-title":"CD4 T cell differentiation in type 1 diabetes","volume":"183","author":"Walker","year":"2016","journal-title":"Clin Exp Immunol"},{"key":"2025052014515990500_B49","doi-asserted-by":"crossref","first-page":"108232","DOI":"10.1016\/j.celrep.2020.108232","article-title":"Continued Bcl6 expression prevents the transdifferentiation of established Tfh cells into Th1 cells during acute viral infection","volume":"33","author":"Alterauge","year":"2020","journal-title":"Cell Rep"},{"key":"2025052014515990500_B50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/imm.12393","article-title":"The transcriptional repressor Bcl6 controls the stability of regulatory T cells by intrinsic and extrinsic pathways","volume":"145","author":"Sawant","year":"2015","journal-title":"Immunology"},{"key":"2025052014515990500_B51","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1056\/NEJMoa1902226","article-title":"An Anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes","volume":"381","author":"Herold","year":"2019","journal-title":"N Engl J Med"},{"key":"2025052014515990500_B52","doi-asserted-by":"crossref","first-page":"100928","DOI":"10.1016\/j.jbc.2021.100928","article-title":"GSK137, a potent small-molecule BCL6 inhibitor with in\u00a0vivo activity, suppresses antibody responses in mice","volume":"297","author":"Pearce","year":"2021","journal-title":"J Biol Chem"},{"key":"2025052014515990500_B53","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1586\/17474086.2013.826928","article-title":"Targeting BCL6 in diffuse large B-cell lymphoma: what does this mean for the future treatment?","volume":"6","author":"Cerchietti","year":"2013","journal-title":"Expert Rev Hematol"},{"key":"2025052014515990500_B54","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41586-023-06348-2","article-title":"Rewiring cancer drivers to activate apoptosis","volume":"620","author":"Gourisankar","year":"2023","journal-title":"Nature"},{"key":"2025052014515990500_B55","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abc8980","article-title":"Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals","volume":"13","author":"Sims","year":"2021","journal-title":"Sci Transl Med"},{"key":"2025052014515990500_B56","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.2337\/dc22-2200","article-title":"Abatacept for delay of type 1 diabetes progression in stage 1 relatives at risk: a randomized, double-masked, controlled trial","volume":"46","author":"Russell","year":"2023","journal-title":"Diabetes Care"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/74\/6\/921\/789768\/db230709.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/74\/6\/921\/789768\/db230709.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T14:52:14Z","timestamp":1747752734000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/6\/921\/157471\/Type-1-Diabetes-Depends-on-CD4-Driven-Expression"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":56,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,11,18]]},"published-print":{"date-parts":[[2025,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-0709","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,18]]}}}