{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:39:36Z","timestamp":1790991576531,"version":"4.1.0"},"reference-count":50,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930057"],"award-info":[{"award-number":["81930057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473982"],"award-info":[{"award-number":["82473982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013088","name":"Qinglan Project of Jiangsu Province of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013088","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Projects of State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture","award":["No.NZYSKL240110"],"award-info":[{"award-number":["No.NZYSKL240110"]}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["23YF1458400"],"award-info":[{"award-number":["23YF1458400"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Program of the Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["23KJA350002"],"award-info":[{"award-number":["23KJA350002"]}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"publisher","award":["23XD1425000"],"award-info":[{"award-number":["23XD1425000"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n                  <jats:p>Diabetic peripheral neuropathy (DPN) is a common diabetes complication with no currently available curative treatments. Here, we demonstrated that the protein level of G-protein\u2013coupled receptor 40 (GPR40) is significantly repressed in the sciatic nerves (SNs) of DPN patients, as well as in the peripheral nerves, including dorsal root ganglia (DRG) and SNs, of streptozotocin-induced type 1 diabetic mice and BKS Cg-m+\/+Lepr db\/J (db\/db) type 2 diabetic mice. We identified that amlodipine besylate (AB), a first-line clinical antihypertensive drug, is a GPR40 agonist capable of alleviating DPN-like pathologies in mice. These pathologies include neurological damage, destruction of myelin sheath structures, vascular injury, loss of intraepidermal nerve fibers, and impaired neurite outgrowth in DRG neurons. To elucidate the underlying mechanisms, we generated the DPN mice with GPR40-specific knockdown in SN and DRG tissues using adeno-associated virus 8-GPR40-RNAi. Mechanistically, AB attenuated inflammatory responses via the GPR40\/\u03b2-arrestin2\/NLRP3 pathway and ameliorated mitochondrial dysfunction through the GPR40\/LKB1\/AMPK\/SIRT1\/PGC-1\u03b1 pathway in DPN mice, which were all further validated in primary human Schwann cells. Additionally, AB suppressed the cross talk between Schwann cells and endothelial cells\/DRG neurons in DPN mice. Collectively, our findings highlight the potential of AB for the treatment of DPN.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Article Highlights<\/jats:title>\n                  <jats:p>The antihypertensive drug amlodipine besylate (AB) is a novel G-protein\u2013coupled receptor 40 agonist able to ameliorate diabetic peripheral neuropathy (DPN)-like pathologies in mice. AB represses inflammation, apoptosis, and mitochondrial dysfunction in DPN mice. AB suppressed the cross talk between Schwann cells and endothelial cells\/dorsal root ganglia neurons. AB shows potential in treating late-stage DPN.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/db24-0403","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T18:05:36Z","timestamp":1740765936000},"page":"983-997","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":6,"title":["Antihypertensive Drug Amlodipine Besylate Shows Potential in Alleviating Diabetic Peripheral Neuropathy"],"prefix":"10.2337","volume":"74","author":[{"given":"Yuxi","family":"Wei","sequence":"first","affiliation":[{"name":"1Jiangsu Key Laboratory of Drug Target and Drug for Degenerative Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Huang","sequence":"additional","affiliation":[{"name":"1Jiangsu Key Laboratory of Drug Target and Drug for Degenerative Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runzhi","family":"Huang","sequence":"additional","affiliation":[{"name":"2Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ruan","sequence":"additional","affiliation":[{"name":"1Jiangsu Key Laboratory of Drug Target and Drug for Degenerative Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Feng","sequence":"additional","affiliation":[{"name":"1Jiangsu Key Laboratory of Drug Target and Drug for Degenerative Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhou","sequence":"additional","affiliation":[{"name":"1Jiangsu Key Laboratory of Drug Target and Drug for Degenerative Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"2Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Lu","sequence":"additional","affiliation":[{"name":"2Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujie","family":"Xie","sequence":"additional","affiliation":[{"name":"2Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Yao","sequence":"additional","affiliation":[{"name":"2Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-6181","authenticated-orcid":false,"given":"Jiaying","family":"Wang","sequence":"additional","affiliation":[{"name":"1Jiangsu Key Laboratory of Drug Target and Drug for Degenerative Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5083-288X","authenticated-orcid":false,"given":"Shizhao","family":"Ji","sequence":"additional","affiliation":[{"name":"2Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-9504","authenticated-orcid":false,"given":"Xu","family":"Shen","sequence":"additional","affiliation":[{"name":"1Jiangsu Key Laboratory of Drug Target and Drug for Degenerative Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China"},{"name":"3State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"2025052014520024000_B1","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.2337\/db19-1084","article-title":"DW14006 as a direct AMPK\u03b1 activator ameliorates diabetic peripheral neuropathy in mice","volume":"69","author":"Xu","year":"2020","journal-title":"Diabetes"},{"key":"2025052014520024000_B2","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.neuron.2017.02.005","article-title":"New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain","volume":"93","author":"Feldman","year":"2017","journal-title":"Neuron"},{"key":"2025052014520024000_B3","doi-asserted-by":"crossref","first-page":"1377923","DOI":"10.3389\/fendo.2024.1377923","article-title":"Diabetic peripheral neuropathy: age-stratified glycemic control","volume":"15","author":"Wang","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2025052014520024000_B4","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1097\/j.pain.0000000000001922","article-title":"Diabetic neuropathy and neuropathic pain: a (con)fusion of pathogenic mechanisms?","volume":"161","author":"Calcutt","year":"2020","journal-title":"Pain"},{"key":"2025052014520024000_B5","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s001250051072","article-title":"Inhibitory effect of troglitazone on diabetic neuropathy in streptozotocin-induced diabetic rats","volume":"41","author":"Qiang","year":"1998","journal-title":"Diabetologia"},{"key":"2025052014520024000_B6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.nano.2019.01.007","article-title":"Nanoparticle-microRNA-146a-5p polyplexes ameliorate diabetic peripheral neuropathy by modulating inflammation and apoptosis","volume":"17","author":"Luo","year":"2019","journal-title":"Nanomedicine"},{"key":"2025052014520024000_B7","doi-asserted-by":"crossref","first-page":"2482453","DOI":"10.1155\/2021\/2482453","article-title":"TSH combined with TSHR aggravates diabetic peripheral neuropathy by promoting oxidative stress and apoptosis in Schwann cells","volume":"2021","author":"Fan","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"2025052014520024000_B8","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2147\/DMSO.S301068","article-title":"Astragaloside IV inhibits mitochondrial-dependent apoptosis of the dorsal root ganglion in diabetic peripheral neuropathy rats through modulation of the SIRT1\/p53 signaling pathway","volume":"14","author":"Ben","year":"2021","journal-title":"Diabetes Metab Syndr Obes"},{"key":"2025052014520024000_B9","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/brain\/aws097","article-title":"Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes","volume":"135","author":"Roy Chowdhury","year":"2012","journal-title":"Brain"},{"key":"2025052014520024000_B10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00125-019-05043-0","article-title":"Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes","volume":"63","author":"Fan","year":"2020","journal-title":"Diabetologia"},{"key":"2025052014520024000_B11","doi-asserted-by":"crossref","first-page":"11047","DOI":"10.1038\/s41598-020-68110-2","article-title":"Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms","volume":"10","author":"Engel","year":"2020","journal-title":"Sci Rep"},{"key":"2025052014520024000_B12","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1038\/s41401-023-01135-1","article-title":"Vincamine as an agonist of G-protein-coupled receptor 40 effectively ameliorates diabetic peripheral neuropathy in mice","volume":"44","author":"Xu","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"2025052014520024000_B13","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12974-021-02209-9","article-title":"Activation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4\/CREB\/KDM6B pathway in an experimental GMH rat model","volume":"18","author":"Xiao","year":"2021","journal-title":"J Neuroinflammation"},{"key":"2025052014520024000_B14","doi-asserted-by":"crossref","first-page":"107432","DOI":"10.1016\/j.phrs.2024.107432","article-title":"GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson's disease animal models","volume":"209","author":"Ha","year":"2024","journal-title":"Pharmacol Res"},{"key":"2025052014520024000_B15","doi-asserted-by":"crossref","first-page":"103283","DOI":"10.1016\/j.redox.2024.103283","article-title":"Mitochondria to plasma membrane redox signaling is essential for fatty acid \u03b2-oxidation-driven insulin secretion","volume":"75","author":"Jab\u016frek","year":"2024","journal-title":"Redox Biol"},{"key":"2025052014520024000_B16","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1111\/dom.15539","article-title":"The GPR40 novel agonist SZZ15-11 improves non-alcoholic fatty liver disease by activating the AMPK pathway and restores metabolic homeostasis in diet-induced obese mice","volume":"26","author":"Lei","year":"2024","journal-title":"Diabetes Obes Metab"},{"key":"2025052014520024000_B17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41574-021-00496-z","article-title":"Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy","volume":"17","author":"Sloan","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"2025052014520024000_B18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1530\/JOE-18-0432","article-title":"Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice","volume":"240","author":"Du","year":"2019","journal-title":"J Endocrinol"},{"key":"2025052014520024000_B19","doi-asserted-by":"crossref","first-page":"E570","DOI":"10.1097\/BRS.0000000000004310","article-title":"Amlodipine improves spinal cord injury repair by inhibiting motoneuronal apoptosis through autophagy upregulation","volume":"47","author":"Huang","year":"2022","journal-title":"Spine (Phila Pa 1976)"},{"key":"2025052014520024000_B20","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/j.1471-4159.2011.07529.x","article-title":"Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress","volume":"119","author":"Lee","year":"2011","journal-title":"J Neurochem"},{"key":"2025052014520024000_B21","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1111\/bph.15768","article-title":"Amlodipine, an anti-hypertensive drug, alleviates non-alcoholic fatty liver disease by modulating gut microbiota","volume":"179","author":"Li","year":"2022","journal-title":"Br J Pharmacol"},{"key":"2025052014520024000_B22","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neuron.2020.11.007","article-title":"Shaping neuronal fate: functional heterogeneity of direct microglia-neuron interactions","volume":"109","author":"Cser\u00e9p","year":"2021","journal-title":"Neuron"},{"key":"2025052014520024000_B23","doi-asserted-by":"crossref","first-page":"856213","DOI":"10.3389\/fnmol.2022.856299","article-title":"The development of mechanical allodynia in diabetic rats revealed by single-cell RNA-Seq","volume":"15","author":"Zhou","year":"2022","journal-title":"Front Mol Neurosci"},{"key":"2025052014520024000_B24","doi-asserted-by":"crossref","first-page":"12524","DOI":"10.3389\/fnmol.2023.1252442","article-title":"Peripheral mechanisms of peripheral neuropathic pain","volume":"16","author":"Pacifico","year":"2023","journal-title":"Front Mol Neurosci"},{"key":"2025052014520024000_B25","doi-asserted-by":"crossref","first-page":"e2114406119","DOI":"10.1073\/pnas.2114406119","article-title":"Pathogenic TNF-\u03b1 drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity","volume":"119","author":"Wang","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025052014520024000_B26","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/jnc.15877","article-title":"Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination","volume":"166","author":"Eid","year":"2023","journal-title":"J Neurochem"},{"key":"2025052014520024000_B27","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1097\/NEN.0b013e3181bef710","article-title":"Nerve growth factor mediates mechanical allodynia in a mouse model of type 2 diabetes","volume":"68","author":"Cheng","year":"2009","journal-title":"J Neuropathol Exp Neurol"},{"key":"2025052014520024000_B28","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.2337\/db15-0133","article-title":"The metabolic syndrome and microvascular complications in a murine model of type 2 diabetes","volume":"64","author":"Hur","year":"2015","journal-title":"Diabetes"},{"key":"2025052014520024000_B29","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.2337\/db09-0034","article-title":"Development of selective axonopathy in adult sensory neurons isolated from diabetic rats: role of glucose-induced oxidative stress","volume":"58","author":"Zherebitskaya","year":"2009","journal-title":"Diabetes"},{"key":"2025052014520024000_B30","doi-asserted-by":"crossref","first-page":"E9153","DOI":"10.1073\/pnas.1711088114","article-title":"Dynein\/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in\u00a0vivo","volume":"114","author":"Herbert","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025052014520024000_B31","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1136\/svn-2022-001568","article-title":"Altered excitability of motor neuron pathways after stroke: more than upper motor neuron impairments","volume":"7","author":"Li","year":"2022","journal-title":"Stroke Vasc Neurol"},{"key":"2025052014520024000_B32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s12974-022-02603-x","article-title":"Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses","volume":"19","author":"Wang","year":"2022","journal-title":"J Neuroinflammation"},{"key":"2025052014520024000_B33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"2025052014520024000_B34","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/cns.14060","article-title":"Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting nerve repair via the TLR4\/NF-\u03baB pathway","volume":"29","author":"Zhang","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"2025052014520024000_B35","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.expneurol.2017.01.005","article-title":"Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury","volume":"290","author":"Lin","year":"2017","journal-title":"Exp Neurol"},{"key":"2025052014520024000_B36","doi-asserted-by":"crossref","first-page":"636172","DOI":"10.3389\/fnins.2021.636172","article-title":"Quercetin attenuates diabetic peripheral neuropathy by correcting mitochondrial abnormality via activation of AMPK\/PGC-1\u03b1 pathway in\u00a0vivo and in\u00a0vitro","volume":"15","author":"Zhang","year":"2021","journal-title":"Front Neurosci"},{"key":"2025052014520024000_B37","doi-asserted-by":"crossref","first-page":"9953","DOI":"10.1111\/jcmm.16810","article-title":"Dihydromyricetin resists inflammation-induced muscle atrophy via ryanodine receptor-CaMKK-AMPK signal pathway","volume":"25","author":"Hou","year":"2021","journal-title":"J Cell Mol Med"},{"key":"2025052014520024000_B38","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13041-016-0194-6","article-title":"AMP-activated protein kinase contributes to zinc-induced neuronal death via activation by LKB1 and induction of Bim in mouse cortical cultures","volume":"9","author":"Eom","year":"2016","journal-title":"Mol Brain"},{"key":"2025052014520024000_B39","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/j.1464-5491.2007.02179.x","article-title":"The effect of alpha-lipoic acid on symptoms and skin blood flow in diabetic neuropathy","volume":"24","author":"Jin","year":"2007","journal-title":"Diabet Med"},{"key":"2025052014520024000_B40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3940(99)00064-6","article-title":"Vascular endothelial growth factor expression in peripheral nerves and dorsal root ganglia in diabetic neuropathy in rats","volume":"262","author":"Samii","year":"1999","journal-title":"Neurosci Lett"},{"key":"2025052014520024000_B41","doi-asserted-by":"crossref","first-page":"774","DOI":"10.2337\/db21-0711","article-title":"GPR40 activation abolishes diabetes-induced painful neuropathy by suppressing VEGF-A expression","volume":"71","author":"K\u00f6nigs","year":"2022","journal-title":"Diabetes"},{"key":"2025052014520024000_B42","doi-asserted-by":"crossref","first-page":"e83204","DOI":"10.1371\/journal.pone.0083204","article-title":"Therapeutic effects of fenofibrate on diabetic peripheral neuropathy by improving endothelial and neural survival in db\/db mice","volume":"9","author":"Cho","year":"2014","journal-title":"PLoS One"},{"key":"2025052014520024000_B43","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1021\/pr300056m","article-title":"C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons","volume":"11","author":"Zhang","year":"2012","journal-title":"J Proteome Res"},{"key":"2025052014520024000_B44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12933-016-0485-3","article-title":"Blood pressure control in type 2 diabetic patients","volume":"16","author":"Grossman","year":"2017","journal-title":"Cardiovasc Diabetol"},{"key":"2025052014520024000_B45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jnutbio.2017.05.001","article-title":"Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy","volume":"47","author":"Yerra","year":"2017","journal-title":"J Nutr Biochem"},{"key":"2025052014520024000_B46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12031-017-0951-8","article-title":"Salidroside ameliorates diabetic neuropathic pain in rats by inhibiting neuroinflammation","volume":"63","author":"Ni","year":"2017","journal-title":"J Mol Neurosci"},{"key":"2025052014520024000_B47","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1136\/bmjdrc-2019-001004","article-title":"Vasomodulation of peripheral blood flow by focused ultrasound potentiates improvement of diabetic neuropathy","volume":"8","author":"Tan","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"key":"2025052014520024000_B48","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12974-021-02273-1","article-title":"Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NF\u03baB to promote axonal regeneration and remyelination","volume":"18","author":"Yadav","year":"2021","journal-title":"J Neuroinflammation"},{"key":"2025052014520024000_B49","first-page":"6266","article-title":"Neuroinflammatory process involved in different preclinical models of chemotherapy-induced peripheral neuropathy","volume":"11","author":"Fumagalli","year":"2020","journal-title":"Front Immunol"},{"key":"2025052014520024000_B50","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cell.2022.12.037","article-title":"Immunity to the microbiota promotes sensory neuron regeneration","volume":"186","author":"Enamorado","year":"2023","journal-title":"Cell"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/74\/6\/983\/800355\/db240403.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/74\/6\/983\/800355\/db240403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T18:52:17Z","timestamp":1747767137000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/6\/983\/157941\/Antihypertensive-Drug-Amlodipine-Besylate-Shows"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":50,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,2,28]]},"published-print":{"date-parts":[[2025,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db24-0403","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]}}}