{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:31:39Z","timestamp":1781641899742,"version":"3.54.5"},"reference-count":28,"publisher":"American Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["20222028"],"award-info":[{"award-number":["20222028"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Obstructive sleep apnea (OSA) is a common condition strongly linked to increased cardiovascular risk and poor glycemic control. Little is known about OSA, cardiovascular risk, and glycemia in maturity-onset diabetes of the young (MODY), an inherited form of diabetes, which is different than both type 1 and type 2 diabetes. We assessed OSA, resting heart rate (RHR), an important prognostic marker of cardiovascular disease, and glycemic variability among the most common subtypes of MODY, glucokinase (GCK)-MODY, and transcription factor (TF)-related MODY (HNF1A, HNF4A, and HNF1B). Adults with GCK-MODY (n = 63) and TF-related MODY (n = 60) and control adults without diabetes (n = 65) were screened for OSA by home sleep test. Glycemic variability (continuous glucose monitoring) and RHR (wearable sleep-activity tracker) were concomitantly assessed for 2 weeks at home. Data from 188 individuals (2,853 recorded days) were analyzed. Individuals with TF-related MODY, compared with those with GCK-MODY or control individuals, had more OSA (48.3%, 27.0%, and 30.8%, respectively; P = 0.033), higher RHR (72.8 \u00b1 10.8, 65.2 \u00b1 7.9, and 67.3 \u00b1 7.7 bpm, respectively; P &amp;lt; 0.001), and higher glycemic variability (coefficient of variation of glucose 31.6 \u00b1 6.0%, 17.3 \u00b1 4.5%, and 17.5 \u00b1 4.0%, respectively; P &amp;lt; 0.001). Greater severity of OSA and higher RHR were associated with higher glycemic variability. These findings may have important clinical implications for cardiovascular risk assessment in MODY.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Article Highlights<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) has been strongly linked to increased cardiovascular risk and poor glycemic control in the general population. Resting heart rate (RHR) is a prognostic marker of cardiovascular morbidity and mortality and has been linked to dysglycemia. Little is known about OSA, RHR, and glycemia in maturity-onset diabetes of the young (MODY), an inherited form of diabetes with discrete clinical features. Adults with transcription factor\u2013related MODY (HNF1A, HNF4A, and HNF1B) had more OSA and higher RHR and greater glycemic variability compared with those with glucokinase-MODY or control adults without diabetes, which may have important clinical implications for future cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/db24-0787","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T20:23:15Z","timestamp":1763065395000},"page":"215-222","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":2,"title":["Obstructive Sleep Apnea, Resting Heart Rate, and Glycemic Variability in Adults With Maturity-Onset Diabetes of the Young"],"prefix":"10.2337","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-4707","authenticated-orcid":false,"given":"Marilyn","family":"Arosemena","sequence":"first","affiliation":[{"name":"Texas Diabetes Institute, University Health, UT Health San Antonio 1 , San Antonio, TX"},{"name":"Universidad Esp\u00edritu Santo 2 , Samborond\u00f3n, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karishma","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Chicago 3 , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V.","family":"Salguero","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Advocate Children's Medical Group 4 , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetra","family":"Reyes","sequence":"additional","affiliation":[{"name":"Kovler Diabetes Center, The University of Chicago 5 , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle N.","family":"Naylor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Chicago 6 , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Wroblewski","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, The University of Chicago 7 , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Tasali","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Chicago 3 , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis H.","family":"Philipson","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Chicago 3 , Chicago, IL"},{"name":"Department of Pediatrics, The University of Chicago 6 , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"2026061115271272600_B1","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000988","article-title":"Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American Heart Association","volume":"144","author":"Yeghiazarians","year":"2021","journal-title":"Circulation"},{"key":"2026061115271272600_B2","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/dme.14211","article-title":"Sweet dreams or bitter nightmare: a narrative review of 25 years of research on the role of sleep in diabetes and the contributions of behavioural science","volume":"37","author":"Nefs","year":"2020","journal-title":"Diabet Med"},{"key":"2026061115271272600_B3","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.2337\/dci20-0065","article-title":"Monogenic diabetes: from genetic insights to population-based precision in care. 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