{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:42:54Z","timestamp":1790066574573,"version":"4.0.1"},"reference-count":52,"publisher":"American Diabetes Association","issue":"8","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008267","name":"Kong Christian den Tiendes Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008267","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18SA0034956"],"award-info":[{"award-number":["NNF18SA0034956"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008733","name":"H\u00f8rslev-Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020035","name":"A. P. M\u00f8llerske St\u00f8ttefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Gastrointestinal hormones are essential for nutrient handling and regulation of glucose metabolism and may affect postprandial blood redistribution. In a randomized cross-over design in 10 healthy men, the involvement of glucose-dependent insulinotropic polypeptide (GIP) in splanchnic blood flow regulation was investigated using an infusion of GIP receptor antagonist (GIPR-An) GIP(3-30)NH2 during ingestion of oral glucose (75 g). In five separate sessions, we investigated GIP(1-42), GIPR-An with and without oral glucose, oral glucose alone, and a control saline infusion. Blood flow was assessed by phase contrast MRI, hepatic oxygen consumption by T2*, and plasma glucose, insulin, C-peptide, glucagon, GIP, GIPR-An, glucagon-like peptide 2, and bone metabolism markers by frequent blood sampling during all sessions. We found GIP(1-42) to stimulate blood flow in the superior mesenteric artery by \u223c10% in the fasting state. Oral glucose alone increased mean blood flow in the superior mesenteric artery by \u223c70% and portal vein by \u223c40% of baseline. During oral glucose ingestion with concurrent infusion of GIPR-An, blood flow in the superior mesenteric artery was \u223c22% lower. The hormone infusions did not affect blood flow in the hepatic artery and the celiac artery. Infusion of GIPR-An during oral glucose ingestion resulted in lower insulin secretion and higher levels of carboxy-terminal collagen crosslinks (bone resorption biomarker) compared with saline infusion, whereas glucagon levels were unaffected by both the injection of GIP and the GIPR-An infusions. We conclude that endogenous GIP increases splanchnic blood flow and contributes to postprandial intestinal hyperemia in healthy men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Article Highlights<\/jats:title>\n                    <jats:p>Administration of the gut hormone glucose-dependent insulinotropic polypeptide (GIP) increases splanchnic blood flow. We investigated the role of endogenous GIP in splanchnic blood flow regulation using a receptor antagonist in humans. Oral glucose ingestion increased blood flow in the superior mesenteric artery by \u223c70%, and the increase was significantly lower during concurrent infusion of the GIP receptor antagonist. Thus, endogenous GIP contributed \u223c22% of the postprandial increase in superior mesenteric artery blood flow. We have identified a novel physiological aspect of vascular biology related to the GIP receptor in humans. Treatments targeting the GIP receptors are likely to affect splanchnic blood flow.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/db25-0149","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T13:34:03Z","timestamp":1748612043000},"page":"1355-1366","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":13,"title":["Glucose-Dependent Insulinotropic Polypeptide Is Involved in Postprandial Regulation of Splanchnic Blood Supply"],"prefix":"10.2337","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5892-7859","authenticated-orcid":false,"given":"Rasmus S.","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen 1 , Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludvig S.","family":"Langberg","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen 1 , Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederikke","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen 1 , Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie W.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen 1 , Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B.","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet\u2013Glostrup, Copenhagen University Hospital 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":false,"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen 1 , Copenhagen, Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen 4 , Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9721-4712","authenticated-orcid":false,"given":"Bryan","family":"Haddock","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet\u2013Glostrup, Copenhagen University Hospital 2 , Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik B.W.","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet\u2013Glostrup, Copenhagen University Hospital 2 , Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette M.","family":"Rosenkilde","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen 1 , Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Asmar","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen University Hospital 3 , Copenhagen, Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital 5 , Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen 6 , 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