{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T19:57:40Z","timestamp":1781207860451,"version":"3.54.1"},"reference-count":45,"publisher":"American Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"name":"Scientific and Technological Research Project of Xinjiang Production and Construction Corps","award":["2021AB028"],"award-info":[{"award-number":["2021AB028"]}]},{"name":"Scientific and Technological Research Project of Xinjiang Production and Construction Corps","award":["2022AB022"],"award-info":[{"award-number":["2022AB022"]}]},{"name":"Scientific and Technological Research Project of Xinjiang Production and Construction Corps","award":["2022ZD001"],"award-info":[{"award-number":["2022ZD001"]}]},{"name":"Scientific and Technological Research Project of Xinjiang Production and Construction Corps","award":["2023AB057"],"award-info":[{"award-number":["2023AB057"]}]},{"name":"Scientific and Technological Research Project of Xinjiang Production and Construction Corps","award":["2023ZD037"],"award-info":[{"award-number":["2023ZD037"]}]},{"name":"Training Program of the Autonomous Region","award":["2023TSYCCX0116"],"award-info":[{"award-number":["2023TSYCCX0116"]}]},{"name":"Training Program of the Autonomous Region","award":["2023TSYCQNTJ0032"],"award-info":[{"award-number":["2023TSYCQNTJ0032"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960152"],"award-info":[{"award-number":["81960152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160156"],"award-info":[{"award-number":["82160156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260162"],"award-info":[{"award-number":["82260162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>miRNAs are key regulators of metabolic homeostasis, yet their role in obesity-associated dysfunction remains incompletely understood. Here, we identify miR-432 as a driver of systemic metabolic dysregulation. Serum miRNA profiling revealed a positive correlation between miR-432 expression and obesity\/type 2 diabetes mellitus. Functionally, adipose-specific miR-432 exacerbated high-fat diet\u2013induced obesity and insulin resistance. Similarly, hepatic-specific miR-432 aggravated hepatic steatosis and systemic glucose dysregulation, while skeletal muscle\u2013specific miR-432 disrupted glucose homeostasis without affecting body composition. Mechanistically, miR-432 disrupted insulin sensitivity by inhibiting the PIK3R3\/AKT pathway and perturbed lipid homeostasis by suppressing the PIK3R3\/PPAR-\u03b1 axis. Notably, obesity-induced miR-432 upregulation was predominantly localized in adipocytes and driven by the CDK5\/PPAR-\u03b3 axis. Furthermore, adipocyte-derived exosomal miR-432 was identified as a mediator of systemic metabolic dysfunction, facilitating intertissue cross talk in obesity. Collectively, our data demonstrate that miR-432 exacerbates obesity-induced dysregulation of glucose and lipid metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Article Highlights<\/jats:title>\n                    <jats:p>miR-432 overexpression in adipose tissue, liver, and skeletal muscle exacerbates high-fat diet\u2013induced disruption of metabolic homeostasis. miR-432 impairs glucose homeostasis by suppressing the PIK3R3\/AKT pathway and disrupts lipid homeostasis via inhibition of the PIK3R3\/PPAR-\u03b1 axis or directly suppressing PPAR-\u03b1. Obesity-induced elevation of miR-432 is predominantly localized in adipocytes and driven by the CDK5\/PPAR-\u03b3 axis. Adipocyte-derived exosomal miR-432 mediates systemic metabolic dysfunction, establishing an intertissue regulatory network.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/db25-0295","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T01:53:02Z","timestamp":1762912382000},"page":"22-36","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":2,"title":["miR-432 Exacerbates Obesity-Induced Dysregulation of Glucose and Lipid Homeostasis"],"prefix":"10.2337","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3338-9732","authenticated-orcid":false,"given":"Cuizhe","family":"Wang","sequence":"first","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan, China"},{"name":"Medical College, Shihezi University 2 , Shihezi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Hou","sequence":"additional","affiliation":[{"name":"Medical College, Shihezi University 2 , Shihezi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical College, Shihezi University 2 , Shihezi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical College, Shihezi University 2 , Shihezi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Chu","sequence":"additional","affiliation":[{"name":"Medical College, Shihezi University 2 , Shihezi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maodi","family":"Liang","sequence":"additional","affiliation":[{"name":"Medical College, Shihezi University 2 , Shihezi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyue","family":"Sun","sequence":"additional","affiliation":[{"name":"Medical College, Shihezi University 2 , Shihezi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2667-5300","authenticated-orcid":false,"given":"Jianxin","family":"Xie","sequence":"additional","affiliation":[{"name":"Medical College, Shihezi University 2 , Shihezi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-994X","authenticated-orcid":false,"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical College, Shihezi University 2 , Shihezi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2362-8111","authenticated-orcid":false,"given":"Cong-Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"2026061115280250800_B1","doi-asserted-by":"crossref","first-page":"110773","DOI":"10.1016\/j.diabres.2023.110773","article-title":"Obesity and diabetes","volume":"202","author":"Boutari","year":"2023","journal-title":"Diabetes Res Clin Pract"},{"key":"2026061115280250800_B2","doi-asserted-by":"crossref","first-page":"eadf7119","DOI":"10.1126\/sciadv.adf7119","article-title":"TNIK is a conserved regulator of glucose and lipid metabolism in obesity","volume":"9","author":"Pham","year":"2023","journal-title":"Sci Adv"},{"key":"2026061115280250800_B3","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3390\/nu16050691","article-title":"MicroRNA 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