{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:07:35Z","timestamp":1789146455538,"version":"build-2803163510"},"reference-count":56,"publisher":"American Diabetes Association","issue":"9","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["K01 DK137050"],"award-info":[{"award-number":["K01 DK137050"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["K08 DK131255"],"award-info":[{"award-number":["K08 DK131255"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P30 DK056341"],"award-info":[{"award-number":["P30 DK056341"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NCI Cancer Center Support, Siteman Cancer Center","award":["P30 CA91842"],"award-info":[{"award-number":["P30 CA91842"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK104995"],"award-info":[{"award-number":["R01 DK104995"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hope Center Alafi Neuroimaging Lab at Washington University School of Medicine","award":["S10 RR027552"],"award-info":[{"award-number":["S10 RR027552"]}]},{"name":"Diabetes Research Center at Washington University in St. Louis","award":["P30 DK020579"],"award-info":[{"award-number":["P30 DK020579"]}]},{"name":"Nutrition Obesity Research Center at Washington University in St. Louis","award":["P30 DK056341"],"award-info":[{"award-number":["P30 DK056341"]}]},{"name":"Digestive Diseases Research Core Center, Washington University in St. Louis","award":["P30 DK052574"],"award-info":[{"award-number":["P30 DK052574"]}]},{"name":"JSPS Kakenhi","award":["20K23382"],"award-info":[{"award-number":["20K23382"]}]},{"name":"JSPS Kakenhi","award":["24K02506"],"award-info":[{"award-number":["24K02506"]}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Nicotinamide phosphoribosyltransferase (NAMPT) maintains the cellular NAD+ pool, and diminished adipocyte NAMPT activity has been implicated in aging- and obesity-related metabolic dysfunction. We generated adipocyte-specific NAMPT overexpressing (ANOV) mice and examined their metabolic phenotypes. Male ANOV mice were protected from high-fat diet\u2013induced metabolic dysfunction, including the development of adipose tissue inflammation and glucose intolerance. In contrast, female ANOV mice were less protected from metabolic dysfunction, possibly due to higher endogenous expression of NAMPT in wild-type female mice. Livers of ANOV mice showed improved insulin signaling, increased NAD+ content, and reduced steatosis, suggesting that NAMPT regulates interorgan communication between adipocytes and hepatocytes. We show that adipose tissue\u2013derived extracellular vesicles (EVs) isolated from ANOV mice enhanced insulin signaling in HepG2 cells and liver and improved glucose tolerance in mice. NAMPT overexpression altered EV cargo composition, including decreased ceramides and increased content of NAD+ and NAMPT. Treating HepG2 cells with an NAMPT inhibitor blunted the effects of ANOV-EV on insulin signaling, suggesting that transfer of NAMPT to recipient cells mediates at least some of the beneficial effects of ANOV-EV. Collectively, these data highlight a novel mechanism by which adipocyte NAMPT regulates systemic metabolic dysfunction via EVs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Article Highlights<\/jats:title>\n                    <jats:p>NAD+ is an essential cofactor for many metabolic reactions. Nicotinamide phosphoribosyltransferase (NAMPT) is an important enzyme in NAD+ biosynthesis, and diminished adipocyte NAD+ and NAMPT have been implicated in metabolic dysfunction. Mice with adipocyte NAMPT overexpression (ANOV) were protected from diet-induced metabolic dysfunction, including adipose tissue inflammation, glucose intolerance, and hepatic steatosis. Extracellular vesicles from ANOV mice improved glucose tolerance in obese mice. Compared with wild-type mice, adipose tissue extracellular vesicles from ANOV mice exhibited marked changes in lipid and metabolite cargoes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/db25-0914","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:19:17Z","timestamp":1783523957000},"page":"1539-1553","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice via Extracellular Vesicles"],"prefix":"10.2337","volume":"75","author":[{"given":"Daniel","family":"Ferguson","sequence":"first","affiliation":[{"name":"Center for Human Nutrition, Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine in St. Louis 1 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise I.","family":"Gadson","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine in St. Louis 1 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen R.","family":"Markan","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine in St. Louis 1 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine in St. Louis 1 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Palacios","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine in St. Louis 1 , St. Louis, MO"},{"name":"Foundational Biomedical Sciences, Touro University California 2 , Vallejo, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine in St. Louis 1 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Habibi","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine in St. Louis 1 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Tiash","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Physiology, Washington University School of Medicine in St. Louis 3 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Cui","sequence":"additional","affiliation":[{"name":"The Genome Engineering and Stem Cell Center, McDonnell Genome Institute, Washington University School of Medicine in St. Louis, St. Louis 4 , MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evguenia","family":"Kouranova","sequence":"additional","affiliation":[{"name":"The Genome Engineering and Stem Cell Center, McDonnell Genome Institute, Washington University School of Medicine in St. Louis, St. Louis 4 , MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edziu","family":"Franczak","sequence":"additional","affiliation":[{"name":"Departments of Cell Biology and Physiology and Division of Endocrinology, Department of Internal Medicine, University of Kansas Medical Center 5 , Kansas City, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Center for Mass Spectrometry and Metabolic Tracing, Department of Chemistry, Washington University 6 , St Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Pediatrics, Washington University School of Medicine in St. Louis 7 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Kealing","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine in St. Louis 1 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri A.","family":"Pietka","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine in St. Louis 1 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim H.H.","family":"Liss","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine in St. Louis 1 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7920-7466","authenticated-orcid":false,"given":"John P.","family":"Thyfault","sequence":"additional","affiliation":[{"name":"Departments of Cell Biology and Physiology and Division of Endocrinology, Department of Internal Medicine, University of Kansas Medical Center 5 , Kansas City, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Patti","sequence":"additional","affiliation":[{"name":"Center for Mass Spectrometry and Metabolic Tracing, Department of Chemistry, Washington University 6 , St Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5411-3674","authenticated-orcid":false,"given":"Brian N.","family":"Finck","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine in St. Louis 1 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clair","family":"Crewe","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Physiology, Washington University School of Medicine in St. Louis 3 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8237-2996","authenticated-orcid":false,"given":"Sandip","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine in St. Louis 1 , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"2026091112164236600_B1","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201600227","article-title":"Adipose tissue NAD+ biology in obesity and insulin resistance: from mechanism to therapy","volume":"39","author":"Yamaguchi","year":"2017","journal-title":"Bioessays"},{"key":"2026091112164236600_B2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.cmet.2011.08.014","article-title":"Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice","volume":"14","author":"Yoshino","year":"2011","journal-title":"Cell Metab"},{"key":"2026091112164236600_B3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD+ metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026091112164236600_B4","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"2026091112164236600_B5","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1042\/BJ20141171","article-title":"Mitochondrial pyruvate transport: a historical perspective and future research directions","volume":"466","author":"McCommis","year":"2015","journal-title":"Biochem J"},{"key":"2026091112164236600_B6","first-page":"12","article-title":"The science behind NMN-a stable, reliable NAD+ activator and anti-aging molecule","volume":"19","author":"Shade","year":"2020","journal-title":"Integr Med (Encinitas)"},{"key":"2026091112164236600_B7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cmet.2007.09.003","article-title":"Nampt\/PBEF\/visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme","volume":"6","author":"Revollo","year":"2007","journal-title":"Cell Metab"},{"key":"2026091112164236600_B8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrendo.2015.117","article-title":"Physiological and pathophysiological roles of NAMPT and NAD metabolism","volume":"11","author":"Garten","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"2026091112164236600_B9","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.cmet.2015.04.002","article-title":"SIRT1-mediated eNAMPT secretion from adipose tissue regulates hypothalamic NAD+ and function in mice","volume":"21","author":"Yoon","year":"2015","journal-title":"Cell Metab"},{"key":"2026091112164236600_B10","doi-asserted-by":"crossref","first-page":"eabj9109","DOI":"10.1126\/sciadv.abj9109","article-title":"eNAMPT actions through nucleus accumbens NAD+\/SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress","volume":"8","author":"Morat\u00f3","year":"2022","journal-title":"Sci Adv"},{"key":"2026091112164236600_B11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cmet.2019.05.015","article-title":"Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice","volume":"30","author":"Yoshida","year":"2019","journal-title":"Cell Metab"},{"key":"2026091112164236600_B12","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/j.celrep.2016.07.027","article-title":"NAMPT-mediated NAD(+) biosynthesis in adipocytes regulates adipose tissue function and multi-organ insulin sensitivity in mice","volume":"16","author":"Stromsdorfer","year":"2016","journal-title":"Cell Rep"},{"key":"2026091112164236600_B13","first-page":"245","article-title":"Association of increased visfatin\/PBEF\/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity","volume":"21","author":"Catal\u00e1n","year":"2011","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2026091112164236600_B14","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cmet.2016.09.013","article-title":"Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice","volume":"24","author":"Mills","year":"2016","journal-title":"Cell Metab"},{"key":"2026091112164236600_B15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.molmet.2018.02.014","article-title":"NAMPT-mediated NAD+ biosynthesis is indispensable for adipose tissue plasticity and development of obesity","volume":"11","author":"Nielsen","year":"2018","journal-title":"Mol Metab"},{"key":"2026091112164236600_B16","article-title":"Efficient creation and characterization of multi-kilobase knockins by CRISPR\/Cas9 and multiple rAAVs","author":"Sentmanat","journal-title":"bioRxiv"},{"key":"2026091112164236600_B17","doi-asserted-by":"crossref","first-page":"e46057","DOI":"10.1371\/journal.pone.0046057","article-title":"Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue","volume":"7","author":"Pettersson","year":"2012","journal-title":"PLoS One"},{"key":"2026091112164236600_B18","doi-asserted-by":"crossref","first-page":"107795","DOI":"10.1016\/j.jdiacomp.2020.107795","article-title":"Phenotypic sexual dimorphism in response to dietary fat manipulation in C57BL\/6J mice","volume":"35","author":"Casimiro","year":"2021","journal-title":"J Diabetes Complications"},{"key":"2026091112164236600_B19","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.2337\/db22-0035","article-title":"Deficient caveolin-1 synthesis in adipocytes stimulates systemic insulin-independent glucose uptake via extracellular vesicles","volume":"71","author":"Crewe","year":"2022","journal-title":"Diabetes"},{"key":"2026091112164236600_B20","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.cmet.2020.12.019","article-title":"MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice","volume":"33","author":"Ying","year":"2021","journal-title":"Cell Metab"},{"key":"2026091112164236600_B21","doi-asserted-by":"crossref","first-page":"101767","DOI":"10.1016\/j.molmet.2023.101767","article-title":"Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo","volume":"75","author":"Mukherjee","year":"2023","journal-title":"Mol Metab"},{"key":"2026091112164236600_B22","doi-asserted-by":"crossref","first-page":"E869","DOI":"10.1152\/ajpendo.00107.2025","article-title":"Loss of ovarian function prevents exercise-induced activation of hepatic mitophagic flux","volume":"328","author":"Franczak","year":"2025","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2026091112164236600_B23","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2019.10.034","article-title":"GPR146 deficiency protects against hypercholesterolemia and atherosclerosis","volume":"179","author":"Yu","year":"2019","journal-title":"Cell"},{"key":"2026091112164236600_B24","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.cell.2018.09.005","article-title":"An endothelial-to-adipocyte extracellular vesicle axis governed by metabolic state","volume":"175","author":"Crewe","year":"2018","journal-title":"Cell"},{"key":"2026091112164236600_B25","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.cmet.2026.02.008","article-title":"Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts","volume":"38","author":"Tiash","year":"2026","journal-title":"Cell Metab"},{"key":"2026091112164236600_B26","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/978-1-4939-7253-1_24","article-title":"Rapid isolation of extracellular vesicles from blood plasma with size-exclusion chromatography followed by mass spectrometry-based proteomic profiling","volume":"1660","author":"Kreimer","year":"2017","journal-title":"Methods Mol Biol"},{"key":"2026091112164236600_B27","doi-asserted-by":"crossref","first-page":"e12385","DOI":"10.1002\/jev2.12385","article-title":"MIBlood-EV: minimal information to enhance the quality and reproducibility of blood extracellular vesicle research","volume":"12","author":"Lucien","year":"2023","journal-title":"J Extracell Vesicles"},{"key":"2026091112164236600_B28","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature21365","article-title":"Adipose-derived circulating miRNAs regulate gene expression in other tissues","volume":"542","author":"Thomou","year":"2017","journal-title":"Nature"},{"key":"2026091112164236600_B29","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/s41598-017-01731-2","article-title":"Labeling extracellular vesicles for nanoscale flow cytometry","volume":"7","author":"Morales-Kastresana","year":"2017","journal-title":"Sci Rep"},{"key":"2026091112164236600_B30","doi-asserted-by":"crossref","first-page":"17370","DOI":"10.1021\/acs.analchem.2c01270","article-title":"An untargeted metabolomics workflow that scales to thousands of samples for population-based studies","volume":"94","author":"Stancliffe","year":"2022","journal-title":"Anal Chem"},{"key":"2026091112164236600_B31","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1038\/s41467-023-39752-3","article-title":"Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels","volume":"14","author":"Peche","year":"2023","journal-title":"Nat Commun"},{"key":"2026091112164236600_B32","doi-asserted-by":"crossref","first-page":"100369","DOI":"10.1016\/j.xcrm.2021.100369","article-title":"Longitudinal metabolomics of human plasma reveals prognostic markers of COVID-19 disease severity","volume":"2","author":"Sindelar","year":"2021","journal-title":"Cell Rep Med"},{"key":"2026091112164236600_B33","doi-asserted-by":"crossref","first-page":"bqz010","DOI":"10.1210\/endocr\/bqz010","article-title":"Role of mineralocorticoid receptor in adipogenesis and obesity in male mice","volume":"161","author":"Ferguson","year":"2020","journal-title":"Endocrinology"},{"key":"2026091112164236600_B34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2026091112164236600_B35","doi-asserted-by":"crossref","first-page":"e169722","DOI":"10.1172\/JCI169722","article-title":"Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in mice","volume":"134","author":"LaPoint","year":"2024","journal-title":"J Clin Invest"},{"key":"2026091112164236600_B36","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1073\/pnas.1720475115","article-title":"Family with sequence similarity 13, member A modulates adipocyte insulin signaling and preserves systemic metabolic homeostasis","volume":"115","author":"Wardhana","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026091112164236600_B37","doi-asserted-by":"crossref","first-page":"876031","DOI":"10.3389\/fcell.2022.876031","article-title":"Retinol binding protein 7 promotes adipogenesis in vitro and regulates expression of genes involved in retinol metabolism","volume":"10","author":"Kim","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2026091112164236600_B38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12933-022-01626-1","article-title":"CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease","volume":"21","author":"Chang","year":"2022","journal-title":"Cardiovasc Diabetol"},{"key":"2026091112164236600_B39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1172\/JCI24335","article-title":"CCR2 modulates inflammatory and metabolic effects of high-fat feeding","volume":"116","author":"Weisberg","year":"2006","journal-title":"J Clin Invest"},{"key":"2026091112164236600_B40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00125-005-0046-x","article-title":"Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents","volume":"49","author":"Somm","year":"2006","journal-title":"Diabetologia"},{"key":"2026091112164236600_B41","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.abe9985","article-title":"Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women","volume":"372","author":"Yoshino","year":"2021","journal-title":"Science"},{"key":"2026091112164236600_B42","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.3389\/fimmu.2019.03133","article-title":"The interplay between tissue niche and macrophage cellular metabolism in obesity","volume":"10","author":"Daemen","year":"2019","journal-title":"Front Immunol"},{"key":"2026091112164236600_B43","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/dom.12171","article-title":"The importance of NAMPT\/NAD\/SIRT1 in the systemic regulation of metabolism and ageing","volume":"15","author":"Imai","year":"2013","journal-title":"Diabetes Obes Metab"},{"key":"2026091112164236600_B44","doi-asserted-by":"crossref","first-page":"115732","DOI":"10.1016\/j.celrep.2025.115732","article-title":"Exploring adipose tissue-derived extracellular vesicles in inter-organ crosstalk: implications for metabolic regulation and adipose tissue function","volume":"44","author":"Le Lay","year":"2025","journal-title":"Cell Rep"},{"key":"2026091112164236600_B45","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.2337\/dc24-2739","article-title":"Effect of marked weight loss on adipose tissue biology in people with obesity and type 2 diabetes","volume":"48","author":"Samovski","year":"2025","journal-title":"Diabetes Care"},{"key":"2026091112164236600_B46","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cmet.2017.11.002","article-title":"NAD+ intermediates: the biology and therapeutic potential of NMN and NR","volume":"27","author":"Yoshino","year":"2018","journal-title":"Cell Metab"},{"key":"2026091112164236600_B47","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2337\/dbi18-0024","article-title":"Targeting metabolism, insulin resistance, and diabetes to treat nonalcoholic steatohepatitis","volume":"67","author":"Finck","year":"2018","journal-title":"Diabetes"},{"key":"2026091112164236600_B48","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41514-025-00297-y","article-title":"Human plasma-derived eNAMPT-containing extracellular vesicles promote NAD+ biosynthesis and thermogenesis in mice","volume":"11","author":"Yoshioka","year":"2025","journal-title":"NPJ Aging"},{"key":"2026091112164236600_B49","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1172\/JCI129186","article-title":"Metabolically healthy obesity: facts and fantasies","volume":"129","author":"Smith","year":"2019","journal-title":"J Clin Invest"},{"key":"2026091112164236600_B50","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cmet.2024.03.002","article-title":"Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity","volume":"36","author":"Petersen","year":"2024","journal-title":"Cell Metab"},{"key":"2026091112164236600_B51","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41514-025-00192-6","article-title":"NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control","volume":"11","author":"Imai","year":"2025","journal-title":"NPJ Aging"},{"key":"2026091112164236600_B52","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.cmet.2021.08.006","article-title":"Exosomes as mediators of intercellular crosstalk in metabolism","volume":"33","author":"Isaac","year":"2021","journal-title":"Cell Metab"},{"key":"2026091112164236600_B53","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41467-020-20500-w","article-title":"High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance","volume":"12","author":"Kumar","year":"2021","journal-title":"Nat Commun"},{"key":"2026091112164236600_B54","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s00109-016-1446-8","article-title":"Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress","volume":"94","author":"Eguchi","year":"2016","journal-title":"J Mol Med (Berl)"},{"key":"2026091112164236600_B55","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.2337\/db17-1308","article-title":"Altered extracellular vesicle concentration, cargo, and function in diabetes","volume":"67","author":"Freeman","year":"2018","journal-title":"Diabetes"},{"key":"2026091112164236600_B56","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/s41574-021-00507-z","article-title":"Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus","volume":"17","author":"Ferguson","year":"2021","journal-title":"Nat Rev Endocrinol"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/75\/9\/1539\/888154\/db250914.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/75\/9\/1539\/888154\/db250914.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:16:56Z","timestamp":1789143416000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/9\/1539\/172158\/Adipose-Tissue-Overexpression-of-Nicotinamide"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":56,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,7,8]]},"published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-0914","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]}}}