{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:05:35Z","timestamp":1790017535241,"version":"4.0.1"},"reference-count":51,"publisher":"American Diabetes Association","issue":"10","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"name":"Maryland Innovation Initiative","award":["TC002488792402"],"award-info":[{"award-number":["TC002488792402"]}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["FAIN:2432114"],"award-info":[{"award-number":["FAIN:2432114"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Breakthrough T1D","award":["1-INO-2025-1708-A-N"],"award-info":[{"award-number":["1-INO-2025-1708-A-N"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R43DK142320"],"award-info":[{"award-number":["1R43DK142320"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R56DK135699"],"award-info":[{"award-number":["1R56DK135699"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\u03b2-Cell maladaptive unfolded protein response is a shared pathogenic feature of type 1 and type 2 diabetes, yet therapeutic strategies that selectively restore \u03b2-cell proteostasis remain limited. Zinc transporter 8 (ZnT8) is an islet-restricted endoplasmic reticulum (ER)\u2013resident membrane protein whose folding burden is amplified under inflammatory stress. Here, we show that cell surface\u2013directed ZnT8 antibodies are internalized and act as selective ZnT8 chaperones, preserving \u03b2-cell function across multiple diabetes models. ZnT8 chaperoning protected \u03b2-cells in prediabetic autoimmune nonobese diabetic (NOD) mice and obesity-associated diabetic mice on an inflammation-prone background, suppressing maladaptive ER stress and MHC class I hyperexpression. In contrast, no protection was observed in inflammation-resistant obesity-associated diabetes or in models of ZnT8-independent proteotoxicity or direct \u03b2-cell cytotoxicity, indicating that ZnT8 chaperoning is contingent on ZnT8-associated inflammatory stress. A humanized Fc-silent derivative, Isle43, showed durable pancreatic retention, dose-dependent reversal of new-onset type 1 diabetes in NOD mice, and sustained remission after treatment cessation. In isolated human islets, ZnT8 chaperoning preserved cytokine-induced reductions in ZnT8 and insulin while attenuating HLA class I and binding immunoglobulin protein induction. Notably, programmed death-ligand 1 (PD-L1) was robustly induced independently of cytokine exposure, identifying PD-L1 as a marker of ZnT8 chaperoning. In vivo, Isle43 accumulated in transplanted human islets and preserved graft-dependent glycemic control in diabetic NOD severe combined immunodeficiency recipients. Together, these findings identify ZnT8 folding burden as a key determinant of \u03b2-cell proteostasis under inflammatory stress and define islet-targeted ZnT8 chaperoning as a precision strategy for preserving \u03b2-cell function in inflammation-dependent diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Article Highlights<\/jats:title>\n                    <jats:p>Inflammatory stress increases endoplasmic reticulum protein-folding burden in \u03b2-cells and amplifies immunogenicity through HLA-I hyperexpression, yet targeted strategies to restore \u03b2-cell proteostasis are lacking. We demonstrate that an islet-specific, cell surface\u2013directed antibody is internalized and functions as a zinc transporter 8\u2013selective chaperone, enhancing endoplasmic reticulum folding capacity, attenuating HLA-I hyperexpression, and robustly inducing programmed death-ligand 1. Identification of programmed death-ligand 1 as a direct pharmacodynamic marker of zinc transporter 8\u2013chaperoning links on-target engagement to reinforcement of local immune checkpoint signaling. Humanized Fc-silent Isle43 shows durable pancreatic retention, dose-dependent reversal of new-onset type 1 diabetes in nonobese diabetic mice, sustained remission after treatment cessation, and protection of human islet graft function in\u00a0vivo. This islet-targeted strategy preserved \u03b2-cell function in inflammatory mouse models and human islet grafts, supporting an islet-targeted therapeutic approach for inflammatory \u03b2-cell failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/db26-0183","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:46:29Z","timestamp":1784555189000},"page":"1892-1905","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Islet-Targeted ZnT8 Antibodies Protect Pancreatic \u03b2-Cells From Inflammatory Stress"],"prefix":"10.2337","volume":"75","author":[{"given":"Zheng","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Physiology, Pharmacology & Therapeutics, Johns Hopkins School of Medicine 1 , Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi","family":"Kasinathan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pharmacology & Therapeutics, Johns Hopkins School of Medicine 1 , Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumei","family":"Yun","sequence":"additional","affiliation":[{"name":"Islex Therapeutics 2 , LLC, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.","family":"Golson","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins School of Medicine 3 , Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-1316","authenticated-orcid":false,"given":"Dax","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pharmacology & Therapeutics, Johns Hopkins School of Medicine 1 , Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"2026092114513220600_B1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41574-020-00443-4","article-title":"Type 1 diabetes mellitus as a disease of the \u03b2-cell (do not blame the immune system?)","volume":"17","author":"Roep","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"2026092114513220600_B2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1172\/JCI88877","article-title":"Islet inflammation in type 2 diabetes and physiology","volume":"127","author":"Eguchi","year":"2017","journal-title":"J Clin Invest"},{"key":"2026092114513220600_B3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41574-020-0355-7","article-title":"Pancreatic \u03b2-cells in type 1 and type 2 diabetes mellitus: different pathways to failure","volume":"16","author":"Eizirik","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"2026092114513220600_B4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"key":"2026092114513220600_B5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ebiom.2018.09.040","article-title":"PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-\u03b1 and-\u03b3 via IRF1 induction","volume":"36","author":"Colli","year":"2018","journal-title":"EBioMedicine"},{"key":"2026092114513220600_B6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.immunol.26.021607.090331","article-title":"PD-1 and its ligands in tolerance and immunity","volume":"26","author":"Keir","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"2026092114513220600_B7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature22396","article-title":"PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity","volume":"545","author":"Gordon","year":"2017","journal-title":"Nature"},{"key":"2026092114513220600_B8","doi-asserted-by":"crossref","first-page":"eaba5573","DOI":"10.1126\/sciadv.aba5573","article-title":"Immunotherapy via PD-L1-presenting biomaterials leads to long-term islet graft survival","volume":"6","author":"Coronel","year":"2020","journal-title":"Sci Adv"},{"key":"2026092114513220600_B9","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1007\/s00125-016-4067-4","article-title":"Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes","volume":"59","author":"Richardson","year":"2016","journal-title":"Diabetologia"},{"key":"2026092114513220600_B10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2337\/db22-0557","article-title":"Inflammatory cell infiltration into islets without PD-L1 expression is associated with the development of immune checkpoint inhibitor-related type 1 diabetes in genetically susceptible patients","volume":"72","author":"Kawata","year":"2023","journal-title":"Diabetes"},{"key":"2026092114513220600_B11","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1007\/s00125-015-3669-6","article-title":"Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms","volume":"58","author":"Brozzi","year":"2015","journal-title":"Diabetologia"},{"key":"2026092114513220600_B12","doi-asserted-by":"crossref","first-page":"211ra156","DOI":"10.1126\/scitranslmed.3006534","article-title":"Restoration of the unfolded protein response in pancreatic \u03b2 cells protects mice against type 1 diabetes","volume":"5","author":"Engin","year":"2013","journal-title":"Sci Transl Med"},{"key":"2026092114513220600_B13","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1128294","article-title":"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes","volume":"313","author":"Ozcan","year":"2006","journal-title":"Science"},{"key":"2026092114513220600_B14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41574-021-00510-4","article-title":"Therapeutic opportunities for pancreatic \u03b2-cell ER stress in diabetes mellitus","volume":"17","author":"Yong","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"2026092114513220600_B15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2016.08.020","article-title":"Single-cell transcriptome profiling of human pancreatic islets in health and type 2 diabetes","volume":"24","author":"Segerstolpe","year":"2016","journal-title":"Cell Metab"},{"key":"2026092114513220600_B16","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.2337\/diabetes.53.9.2330","article-title":"Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules","volume":"53","author":"Chimienti","year":"2004","journal-title":"Diabetes"},{"key":"2026092114513220600_B17","doi-asserted-by":"crossref","first-page":"16992","DOI":"10.1074\/jbc.RA119.010937","article-title":"Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress","volume":"294","author":"Merriman","year":"2019","journal-title":"J Biol Chem"},{"key":"2026092114513220600_B18","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1038\/s41467-024-49724-w","article-title":"Identification of unique cell type responses in pancreatic islets to stress","volume":"15","author":"Maestas","year":"2024","journal-title":"Nat Commun"},{"key":"2026092114513220600_B19","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/s41588-019-0513-9","article-title":"Loss of ZnT8 function protects against diabetes by enhanced insulin secretion","volume":"51","author":"Dwivedi","year":"2019","journal-title":"Nat Genet"},{"key":"2026092114513220600_B20","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1038\/s41467-022-31829-9","article-title":"ZnT8 loss-of-function accelerates functional maturation of hESC-derived \u03b2 cells and resists metabolic stress in diabetes","volume":"13","author":"Ma","year":"2022","journal-title":"Nat Commun"},{"key":"2026092114513220600_B21","doi-asserted-by":"crossref","first-page":"E7642","DOI":"10.1073\/pnas.1721418115","article-title":"Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity","volume":"115","author":"Kleiner","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026092114513220600_B22","doi-asserted-by":"crossref","first-page":"101632","DOI":"10.1016\/j.molmet.2022.101632","article-title":"Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration","volume":"66","author":"Kim","year":"2022","journal-title":"Mol Metab"},{"key":"2026092114513220600_B23","doi-asserted-by":"crossref","first-page":"14872","DOI":"10.1073\/pnas.0906587106","article-title":"Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice","volume":"106","author":"Lemaire","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026092114513220600_B24","unstructured":"Human Protein Atlas\n          . SLC30A8. Accessed 18 February 2026. Available from https:\/\/www.proteinatlas.org\/ENSG00000164756-SLC30A8\/tissue"},{"key":"2026092114513220600_B25","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1074\/jbc.M116.772152","article-title":"Coupling of insulin secretion and display of a granule-resident zinc transporter ZnT8 on the surface of pancreatic beta cells","volume":"292","author":"Huang","year":"2017","journal-title":"J Biol Chem"},{"key":"2026092114513220600_B26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2337\/db22-0477","article-title":"Cell-surface autoantibody targets zinc transporter-8 (ZnT8) for in vivo \u03b2-cell imaging and islet-specific therapies","volume":"72","author":"Guo","year":"2023","journal-title":"Diabetes"},{"key":"2026092114513220600_B27","doi-asserted-by":"crossref","first-page":"17040","DOI":"10.1073\/pnas.0705894104","article-title":"The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes","volume":"104","author":"Wenzlau","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026092114513220600_B28","doi-asserted-by":"crossref","first-page":"102677","DOI":"10.1016\/j.jaut.2021.102677","article-title":"Novel autoantibodies to the \u03b2-cell surface epitopes of ZnT8 in patients progressing to type-1 diabetes","volume":"122","author":"Gu","year":"2021","journal-title":"J Autoimmun"},{"key":"2026092114513220600_B29","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1074\/jbc.RA117.000195","article-title":"A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic \u03b2-cells","volume":"293","author":"Merriman","year":"2018","journal-title":"J Biol Chem"},{"key":"2026092114513220600_B30","doi-asserted-by":"crossref","first-page":"806","DOI":"10.2337\/db23-0568","article-title":"Cell-surface ZnT8 antibody prevents and reverses autoimmune diabetes in mice","volume":"73","author":"Kasinathan","year":"2024","journal-title":"Diabetes"},{"key":"2026092114513220600_B31","doi-asserted-by":"crossref","first-page":"26950","DOI":"10.1074\/jbc.M116.764605","article-title":"Lipid-tuned zinc transport activity of human ZnT8 protein correlates with risk for type-2 diabetes","volume":"291","author":"Merriman","year":"2016","journal-title":"J Biol Chem"},{"key":"2026092114513220600_B32","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1172\/JCI58447","article-title":"A genetically engineered human pancreatic \u03b2 cell line exhibiting glucose-inducible insulin secretion","volume":"121","author":"Ravassard","year":"2011","journal-title":"J Clin Invest"},{"key":"2026092114513220600_B33","doi-asserted-by":"crossref","first-page":"E1460","DOI":"10.1152\/ajpendo.00591.2013","article-title":"Automated quantification of pancreatic \u03b2-cell mass","volume":"306","author":"Golson","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2026092114513220600_B34","doi-asserted-by":"crossref","first-page":"109118","DOI":"10.1016\/j.clim.2022.109118","article-title":"Liraglutide protects \u03b2-cells in novel human islet spheroid models of type 1 diabetes","volume":"244","author":"Yesildag","year":"2022","journal-title":"Clin Immunol"},{"key":"2026092114513220600_B35","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s42255-020-0269-7","article-title":"Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes","volume":"2","author":"Yu","year":"2020","journal-title":"Nat Metab"},{"key":"2026092114513220600_B36","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1182\/blood-2010-09-305847","article-title":"Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I\/II distinction of CD20 antibodies","volume":"118","author":"Niederfellner","year":"2011","journal-title":"Blood"},{"key":"2026092114513220600_B37","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.2337\/db15-0449","article-title":"Acute versus progressive onset of diabetes in NOD mice: potential implications for therapeutic interventions in type 1 diabetes","volume":"64","author":"Mathews","year":"2015","journal-title":"Diabetes"},{"key":"2026092114513220600_B38","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2337\/db11-1293","article-title":"Islet \u03b2-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model","volume":"61","author":"Tersey","year":"2012","journal-title":"Diabetes"},{"key":"2026092114513220600_B39","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.2337\/db12-0701","article-title":"Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in \u03b2-cell gene expression and progression to diabetes","volume":"62","author":"Chan","year":"2013","journal-title":"Diabetes"},{"key":"2026092114513220600_B40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41574-019-0286-3","article-title":"The role of macrophages in obesity-associated islet inflammation and \u03b2-cell abnormalities","volume":"16","author":"Ying","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"2026092114513220600_B41","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.2337\/db06-1650","article-title":"Increased number of islet-associated macrophages in type 2 diabetes","volume":"56","author":"Ehses","year":"2007","journal-title":"Diabetes"},{"key":"2026092114513220600_B42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1172\/JCI4431","article-title":"A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse","volume":"103","author":"Wang","year":"1999","journal-title":"J Clin Invest"},{"key":"2026092114513220600_B43","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"key":"2026092114513220600_B44","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1172\/JCI117188","article-title":"Cytokines suppress human islet function irrespective of their effects on nitric oxide generation","volume":"93","author":"Eizirik","year":"1994","journal-title":"J Clin Invest"},{"key":"2026092114513220600_B45","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nri2017","article-title":"Humanized mice in translational biomedical research","volume":"7","author":"Shultz","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"2026092114513220600_B46","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng.2915","article-title":"Loss-of-function mutations in SLC30A8 protect against type 2 diabetes","volume":"46","author":"Flannick","year":"2014","journal-title":"Nat Genet"},{"key":"2026092114513220600_B47","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1007\/s00125-017-4536-4","article-title":"IFN-\u03b1 induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells","volume":"61","author":"Coomans de Brach\u00e8ne","year":"2018","journal-title":"Diabetologia"},{"key":"2026092114513220600_B48","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s00125-016-4201-3","article-title":"Interferon-\u03b1 mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes","volume":"60","author":"Marroqui","year":"2017","journal-title":"Diabetologia"},{"key":"2026092114513220600_B49","doi-asserted-by":"crossref","first-page":"12632","DOI":"10.1038\/ncomms12632","article-title":"Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity","volume":"7","author":"Li","year":"2016","journal-title":"Nat Commun"},{"key":"2026092114513220600_B50","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-immunol-032712-095910","article-title":"Pathways of antigen processing","volume":"31","author":"Blum","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"2026092114513220600_B51","doi-asserted-by":"crossref","first-page":"115569","DOI":"10.1016\/j.biopha.2023.115569","article-title":"The therapeutic potential of PD-1\/PD-L1 pathway on immune-related diseases: based on the innate and adaptive immune components","volume":"167","author":"Zhang","year":"2023","journal-title":"Biomed Pharmacother"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/75\/10\/1892\/889425\/db260183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/75\/10\/1892\/889425\/db260183.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:51:46Z","timestamp":1790016706000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/10\/1892\/172237\/Islet-Targeted-ZnT8-Antibodies-Protect-Pancreatic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":51,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,7,20]]},"published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db26-0183","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]}}}