{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:30:29Z","timestamp":1788413429808,"version":"build-2803163510"},"reference-count":24,"publisher":"American Diabetes Association","issue":"5","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["DK036836"],"award-info":[{"award-number":["DK036836"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["DK098085"],"award-info":[{"award-number":["DK098085"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["DK130846"],"award-info":[{"award-number":["DK130846"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["DK138210"],"award-info":[{"award-number":["DK138210"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["Dk120393"],"award-info":[{"award-number":["Dk120393"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","award":["SRA-2024-1518-S-B"],"award-info":[{"award-number":["SRA-2024-1518-S-B"]}],"id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"DOI":"10.2337\/dbi25-0007","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T15:48:45Z","timestamp":1746632925000},"page":"682-684","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":4,"title":["Bend It Like Occam: Ductal Origin of New Islet Cells in Human Pancreas After Injury"],"prefix":"10.2337","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-9143","authenticated-orcid":false,"given":"Juan","family":"Dom\u00ednguez-Bendala","sequence":"first","affiliation":[{"name":"1Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4682-0656","authenticated-orcid":false,"given":"Susan","family":"Bonner-Weir","sequence":"additional","affiliation":[{"name":"2Joslin Diabetes Center, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"2025050711475728800_B1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature02520","article-title":"Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation","volume":"429","author":"Dor","year":"2004","journal-title":"Nature"},{"key":"2025050711475728800_B2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1399-543X.2004.00075.x","article-title":"The pancreatic ductal epithelium serves as a potential pool of progenitor cells","volume":"5","author":"Bonner-Weir","year":"2004","journal-title":"Pediatr Diabetes"},{"key":"2025050711475728800_B3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cmet.2017.08.007","article-title":"Pancreatic \u03b2 cell regeneration as a possible therapy for diabetes","volume":"27","author":"Aguayo-Mazzucato","year":"2018","journal-title":"Cell Metab"},{"key":"2025050711475728800_B4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.tem.2018.10.002","article-title":"Pancreatic progenitors: there and back again","volume":"30","author":"Dom\u00ednguez-Bendala","year":"2019","journal-title":"Trends Endocrinol Metab"},{"key":"2025050711475728800_B5","doi-asserted-by":"crossref","first-page":"19915","DOI":"10.1073\/pnas.0805803105","article-title":"Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth","volume":"105","author":"Inada","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025050711475728800_B6","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1053\/j.gastro.2011.07.003","article-title":"Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice","volume":"141","author":"Criscimanna","year":"2011","journal-title":"Gastroenterology"},{"key":"2025050711475728800_B7","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1073\/pnas.1524200113","article-title":"Growth factors and medium hyperglycemia induce Sox9+ ductal cell differentiation into \u03b2 cells in mice with reversal of diabetes","volume":"113","author":"Zhang","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025050711475728800_B8","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.devcel.2009.11.003","article-title":"Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth","volume":"17","author":"Solar","year":"2009","journal-title":"Dev Cell"},{"key":"2025050711475728800_B9","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1242\/dev.056499","article-title":"Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas","volume":"138","author":"Kopp","year":"2011","journal-title":"Development"},{"key":"2025050711475728800_B10","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.stem.2023.02.005","article-title":"Ductal Ngn3-expressing progenitors contribute to adult \u03b2 cell neogenesis in the pancreas","volume":"30","author":"Gribben","year":"2023","journal-title":"Cell Stem Cell"},{"key":"2025050711475728800_B11","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.stem.2023.03.003","article-title":"Matters arising: insufficient evidence that pancreatic \u03b2 cells are derived from adult ductal Neurog3-expressing progenitors","volume":"30","author":"Magenheim","year":"2023","journal-title":"Cell Stem Cell"},{"key":"2025050711475728800_B12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.stem.2023.03.002","article-title":"Response to Magenheim et\u00a0al.: ductal Ngn3-expressing progenitors contribute to adult beta cell neogenesis in the pancreas","volume":"30","author":"Gribben","year":"2023","journal-title":"Cell Stem Cell"},{"key":"2025050711475728800_B13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/03009734.2016.1154906","article-title":"Dynamic development of the pancreas from birth to adulthood","volume":"121","author":"Bonner-Weir","year":"2016","journal-title":"Ups J Med Sci"},{"key":"2025050711475728800_B14","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.2337\/db15-0153","article-title":"Centroacinar cells are progenitors that contribute to endocrine pancreas regeneration","volume":"64","author":"Delaspre","year":"2015","journal-title":"Diabetes"},{"key":"2025050711475728800_B15","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1242\/jcs.065268","article-title":"Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats","volume":"123","author":"Li","year":"2010","journal-title":"J Cell Sci"},{"key":"2025050711475728800_B16","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.stemcr.2018.01.028","article-title":"Heterogeneity of SOX9 and HNF1\u03b2 in pancreatic ducts is dynamic","volume":"10","author":"Rezanejad","year":"2018","journal-title":"Stem Cell Reports"},{"key":"2025050711475728800_B17","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1016\/j.celrep.2018.02.006","article-title":"P2RY1\/ALK3-expressing cells within the adult human exocrine pancreas are BMP-7 expandable and exhibit progenitor-like characteristics","volume":"22","author":"Qadir","year":"2018","journal-title":"Cell Rep"},{"key":"2025050711475728800_B18","doi-asserted-by":"crossref","first-page":"10876","DOI":"10.1073\/pnas.1918314117","article-title":"Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche","volume":"117","author":"Qadir","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025050711475728800_B19","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.stemcr.2023.02.001","article-title":"Methylcellulose colony assay and single-cell micro-manipulation reveal progenitor-like cells in adult human pancreatic ducts","volume":"18","author":"Quijano","year":"2023","journal-title":"Stem Cell Rep"},{"key":"2025050711475728800_B20","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1073\/pnas.97.14.7999","article-title":"In vitro cultivation of human islets from expanded ductal tissue","volume":"97","author":"Bonner-Weir","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025050711475728800_B21","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.2337\/db06-1670","article-title":"Differentiation of affinity-purified human pancreatic duct cells to \u03b2-cells","volume":"56","author":"Yatoh","year":"2007","journal-title":"Diabetes"},{"key":"2025050711475728800_B22","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00125-008-1105-x","article-title":"Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity","volume":"51","author":"Martin-Pagola","year":"2008","journal-title":"Diabetologia"},{"key":"2025050711475728800_B23","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1016\/j.cmet.2023.10.001","article-title":"Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage","volume":"35","author":"Doke","year":"2023","journal-title":"Cell Metab"},{"key":"2025050711475728800_B24","first-page":"734","article-title":"3D imaging resolves human pancreatic duct\u2013\u03b2-cell clusters during cystic change","volume":"74","author":"Lee","year":"2025","journal-title":"Diabetes"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/74\/5\/682\/803092\/dbi250007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/74\/5\/682\/803092\/dbi250007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T15:48:49Z","timestamp":1746632929000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/5\/682\/158072\/Bend-It-Like-Occam-Ductal-Origin-of-New-Islet"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,4,21]]},"published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dbi25-0007","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,21]]}}}