{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:09:07Z","timestamp":1792012147768,"version":"4.4.0"},"reference-count":54,"publisher":"American Diabetes Association","issue":"6","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:p>OBJECTIVE\u2014To prospectively determine risk factors for foot infection in a cohort of people with diabetes.<\/jats:p>\n                  <jats:p>RESEARCH DESIGN AND METHODS\u2014We evaluated then followed 1,666 consecutive diabetic patients enrolled in a managed care\u2013based outpatient clinic in a 2-year longitudinal outcomes study. At enrollment, patients underwent a standardized general medical examination and detailed foot assessment and were educated about proper foot care. They were then rescreened at scheduled intervals and also seen promptly if they developed any foot problem.<\/jats:p>\n                  <jats:p>RESULTS\u2014During the evaluation period, 151 (9.1%) patients developed 199 foot infections, all but one involving a wound or penetrating injury. Most patients had infections involving only the soft tissue, but 19.9% had bone culture\u2013proven osteomyelitis. For those who developed a foot infection, compared with those who did not, the risk of hospitalization was 55.7 times greater (95% CI 30.3\u2013102.2; P &amp;lt; 0.001) and the risk of amputation was 154.5 times greater (58.5\u2013468.5; P &amp;lt; 0.001). Foot wounds preceded all but one infection. Significant (P &amp;lt; 0.05) independent risk factors for foot infection from a multivariate analysis included wounds that penetrated to bone (odds ratio 6.7), wounds with a duration &amp;gt;30 days (4.7), recurrent wounds (2.4), wounds with a traumatic etiology (2.4), and presence of peripheral vascular disease (1.9).<\/jats:p>\n                  <jats:p>CONCLUSIONS\u2014Foot infections occur relatively frequently in individuals with diabetes, almost always follow trauma, and dramatically increase the risk of hospitalization and amputation. Efforts to prevent infections should be targeted at people with traumatic foot wounds, especially those that are chronic, deep, recurrent, or associated with peripheral vascular disease.<\/jats:p>","DOI":"10.2337\/dc05-2425","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T20:32:06Z","timestamp":1148675526000},"page":"1288-1293","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":627,"title":["Risk Factors for Foot Infections in Individuals With Diabetes"],"prefix":"10.2337","volume":"29","author":[{"given":"Lawrence A.","family":"Lavery","sequence":"first","affiliation":[{"name":"Department of Surgery, Scott and White Hospital, Texas A&M University Health Science Center College of Medicine, Temple, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Dr. William M. Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, Chicago, Illinois"},{"name":"Department of Medicine, Manchester Royal Infirmary, Manchester, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Wunderlich","sequence":"additional","affiliation":[{"name":"Department of Medicine, Diabetex, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Jane","family":"Mohler","sequence":"additional","affiliation":[{"name":"Research Service, Southern Arizona Veterans Affairs Medical Center, Tucson, Arizona"},{"name":"Epidemiology and Biostatistics Division, College of Public Health, University of Arizona, Tucson, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Wendel","sequence":"additional","affiliation":[{"name":"Research Service, Southern Arizona Veterans Affairs Medical Center, Tucson, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Lipsky","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington and the VA Puget Sound Heath Care System, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031216365081900_R1","unstructured":"Boulton AJ, Vileikyte L: The diabetic foot: the scope of the problem J Fam Pract\u200849(Suppl. 11): S3\u2013S8, 2000"},{"key":"2022031216365081900_R2","unstructured":"Levin M: Pathophysiology of diabetic foot lesions. 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