{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:56:18Z","timestamp":1789509378839,"version":"build-2803163510"},"reference-count":32,"publisher":"American Diabetes Association","issue":"7","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,7,1]]},"abstract":"<jats:p>OBJECTIVE\u2014Diabetes increases the risk for cerebromicrovascular disease, possibly through its effects on blood flow regulation. The aim of this study was to assess the effects of type 2 diabetes on blood flow velocities (BFVs) in the middle cerebral arteries and to determine the relationship between white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) and BFVs.<\/jats:p>\n                  <jats:p>RESEARCH DESIGN AND METHODS\u2014We measured BFVs in 28 type 2 diabetic and 22 control subjects (aged 62.3 \u00b1 7.2 years) using transcranial Doppler ultrasound during baseline, hyperventilation, and CO2 rebreathing. WMHs were graded, and their volume was quantified from fluid-attenuated inversion recovery images on a 3.0 Tesla MRI.<\/jats:p>\n                  <jats:p>RESULTS\u2014The diabetic group demonstrated decreased mean BFVs and increased cerebrovascular resistance during baseline, hypo- and hypercapnia (P &amp;lt; 0.0001), and impaired CO2 reactivity (P = 0.05). WMH volume was negatively correlated with baseline BFV (P &amp;lt; 0.0001). A regression model revealed that baseline BFVs were negatively associated with periventricular WMHs, HbA1c (A1C), and inflammatory markers and positively associated with systolic blood pressure (R2 = 0.86, P &amp;lt; 0.0001).<\/jats:p>\n                  <jats:p>CONCLUSIONS\u2014Microvascular disease in type 2 diabetes, which manifests as white matter abnormalities on MRI, is associated with reduced cerebral BFVs, increased resistance in middle cerebral arteries, and inflammation. These findings are clinically relevant as a potential mechanism for cerebrovascular disease in elderly with type 2 diabetes.<\/jats:p>","DOI":"10.2337\/dc06-0261","type":"journal-article","created":{"date-parts":[[2006,6,26]],"date-time":"2006-06-26T17:13:17Z","timestamp":1151341997000},"page":"1529-1534","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":138,"title":["Cerebral Blood Flow Velocity and Periventricular White Matter Hyperintensities in Type 2 Diabetes"],"prefix":"10.2337","volume":"29","author":[{"given":"Vera","family":"Novak","sequence":"first","affiliation":[{"name":"Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Last","sequence":"additional","affiliation":[{"name":"Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Alsop","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir M.","family":"Abduljalil","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Lepicovsky","sequence":"additional","affiliation":[{"name":"Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Cavallerano","sequence":"additional","affiliation":[{"name":"Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis A.","family":"Lipsitz","sequence":"additional","affiliation":[{"name":"Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"},{"name":"Hebrew SeniorLife, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031219253854900_R1","doi-asserted-by":"crossref","unstructured":"Xu WL, Qiu CX, Wahlin A, Winblad B, Fratiglioni L: Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study. 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