{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:15:47Z","timestamp":1790471747398,"version":"4.1.0"},"reference-count":17,"publisher":"American Diabetes Association","issue":"9","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,9,1]]},"abstract":"<jats:p>OBJECTIVE\u2014Some previous studies suggested that patients suffering from Wolfram syndrome or DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness) might be relatively preserved from diabetic retinopathy and nephropathy. However, these data were not conclusive because either observations were only anecdotic or did not match with control type 1 diabetic populations.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014A group of 26 French diabetic patients with DIDMOAD was compared with a population of 52 patients with common type 1 diabetes matched for age at diabetes diagnosis (8.62 \u00b1 1.84 vs. 8.27 \u00b1 1.30 years; P = NS) and diabetes duration (12.88 \u00b1 1.58 vs. 12.87 \u00b1 1.13 years; P = NS) to study the quality of glycemic control and the incidence of microvascular complications.<\/jats:p>\n               <jats:p>RESULTS\u2014Glycemic control was significantly better in the DIDMOAD group than in the type 1 diabetic group (A1C: 7.72 \u00b1 0.21 vs. 8.99 \u00b1 0.25%, respectively; P = 0.002), with significant lower daily insulin requirements (0.71 \u00b1 0.07 vs. 0.88 \u00b1 0.04 UI \u00b7 kg\u22121 \u00b7 day\u22121, respectively; P = 0.0325). The prevalence of microvascular complications in the DIDMOAD group was half that observed in the type 1 diabetic group, but the difference was not significant.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014Diabetes in DIDMOAD patients is more easily controlled despite the presence of other handicaps. This better glycemic control could explain the trend to decreased microvascular diabetes complications observed in previous studies.<\/jats:p>","DOI":"10.2337\/dc07-0380","type":"journal-article","created":{"date-parts":[[2007,8,28]],"date-time":"2007-08-28T22:43:20Z","timestamp":1188341000000},"page":"2327-2330","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":48,"title":["Microvascular Diabetes Complications in Wolfram Syndrome (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness [DIDMOAD])"],"prefix":"10.2337","volume":"30","author":[{"given":"Aline","family":"Cano","sequence":"first","affiliation":[{"name":"Department of Nutrition, Metabolic Diseases and Endocrinology, University of Me\u0301diterrane\u0301e, \u201cLa Timone\u201d Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Molines","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Metabolic Diseases and Endocrinology, University of Me\u0301diterrane\u0301e, \u201cLa Timone\u201d Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene\u0301","family":"Vale\u0301ro","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Metabolic Diseases and Endocrinology, University of Me\u0301diterrane\u0301e, \u201cLa Timone\u201d Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Simonin","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Metabolic Diseases and Endocrinology, University of Me\u0301diterrane\u0301e, \u201cLa Timone\u201d Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ve\u0301ronique","family":"Paquis-Flucklinger","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Nice, \u201cArchet-2\u201d Hospital, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Vialettes","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Metabolic Diseases and Endocrinology, University of Me\u0301diterrane\u0301e, \u201cLa Timone\u201d Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the French Group of Wolfram Syndrome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031219323450600_R1","doi-asserted-by":"crossref","unstructured":"Barrett TG, Bundey SE, Mcleod AF: Neurodegeneration and diabetes: U.K. nationwide study of Wolfram (DIDMOAD) syndrome. 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