{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:00:54Z","timestamp":1791338454272,"version":"4.3.1"},"reference-count":42,"publisher":"American Diabetes Association","issue":"3","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:p>OBJECTIVE\u2014We measured plasma markers of endothelial dysfunction, vascular inflammation, and pro-coagulation in obese Hispanic\/Latino children and adolescents with normal glucose tolerance and determined their relationship to body composition and indexes of glucose and lipid metabolism.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014A total of 38 lean or obese Hispanic children and adolescents (10\u201318 years of age) were selected. The overweight group (n = 21) had a BMI &amp;gt;85th percentile for their age and sex, and the lean group (n = 17) had a BMI between the 25th and 50th percentiles. Studies included an oral glucose tolerance test, measurements of plasma glucose and lipids, several markers of endothelial function and inflammation, and determination of body composition by dual X-ray absorptiometry.<\/jats:p>\n               <jats:p>RESULTS\u2014The obese group had higher systolic blood pressure and plasma triglycerides and was more insulin resistant than the lean group. The obese group also had higher plasma soluble intercellular adhesion molecule (259.5 \u00b1 60.0 vs. 223.2 \u00b1 47.5 ng\/ml, P = 0.047), tumor necrosis factor-\u03b1 (2.57 \u00b1 1.1 vs. 1.74 \u00b1 0.6 pg\/ml, P = 0.008), high-sensitivity C-reactive protein (2.0 vs. 0.13 mg\/l, P &amp;lt; 0.0001), plasminogen-activated inhibitor-1 (47.0 \u00b1 35.7 vs. 12.0 \u00b1 5.2 ng\/ml, P &amp;lt; 0.0001), tissue plasminogen activator (6.1 \u00b1 1.9 vs. 4.1 \u00b1 0.8 ng\/ml, P = 0.001), and white blood cell count (6.9 vs. 5.3 \u00d7 103, P = 0.031) and lower levels of adiponectin (8.7 \u00b1 3.3 vs. 12.6 \u00b1 5.2 \u03bcg\/ml, P = 0.022). No significant differences were observed for soluble vascular cell adhesion molecule or interleukin-6.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014Overweight Hispanic children and adolescents with normal glucose tolerance exhibit increased plasma markers of endothelial dysfunction and subclinical inflammation in association with obesity and insulin resistance. These abnormalities may predispose them to the development of type 2 diabetes and cardiovascular disease.<\/jats:p>","DOI":"10.2337\/dc07-1540","type":"journal-article","created":{"date-parts":[[2008,2,28]],"date-time":"2008-02-28T03:30:20Z","timestamp":1204169420000},"page":"576-582","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":104,"title":["Overweight Latino Children and Adolescents Have Marked Endothelial Dysfunction and Subclinical Vascular Inflammation in Association With Excess Body Fat and Insulin Resistance"],"prefix":"10.2337","volume":"31","author":[{"given":"A. Enrique","family":"Caballero","sequence":"first","affiliation":[{"name":"Joslin Diabetes Center, Clinical Research Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelb","family":"Bousquet-Santos","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Niteru\u0308i, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludivina","family":"Robles-Osorio","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center, Clinical Research Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Montagnani","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center, Clinical Research Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Soodini","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center, Clinical Research Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriurai","family":"Porramatikul","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center, Clinical Research Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center, Clinical Research Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio C.L.","family":"Nobrega","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Niteru\u0308i, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward S.","family":"Horton","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center, Clinical Research Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031217501952700_R1","doi-asserted-by":"crossref","unstructured":"Sullivan PW, Morrato EH, Ghushchyan V, Wyatt HR, Hill JO: Obesity, inactivity, and the prevalence of diabetes and diabetes-related cardiovascular comorbidities in the US, 2000\u20132002. 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