{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T04:23:09Z","timestamp":1768537389304,"version":"3.49.0"},"reference-count":23,"publisher":"American Diabetes Association","issue":"9","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:p>OBJECTIVE\u2014We tested whether determination of the ACE insertion\/deletion polymorphism is useful for renal and cardiovascular prognoses of type 2 diabetic subjects.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014The French participants (3,126 of 4,912) in the Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR) trial were studied for their prognosis over 4 years according to their ACE insertion\/deletion polymorphism. We used two cohorts of French type 2 diabetic patients for replication: a 3-year follow-up study (n = 917; Survie, Diabete de type 2 et Genetique [SURDIAGENE] study) and a case-control study on diabetic nephropathy (n = 1,277; Diabete de type 2, Nephropathie et Genetique [DIAB2NEPHROGENE] study). We investigated the effect of the insertion\/deletion polymorphism on the primary outcome in the DIABHYCAR trial (defined as the first of the following events to occur: cardiovascular death, nonfatal myocardial infarction, stroke, heart failure leading to hospital admission, or end-stage renal failure) and its components.<\/jats:p>\n               <jats:p>RESULTS\u2014In DIABHYCAR, the primary outcome and most of its components were not affected by the ACE insertion\/deletion genotype. Only renal outcome was favored by the I allele (P = 0.03). The risk of myocardial infarction was not affected by ACE genotype, but the probability of fatal outcome increased with the number of D alleles (P &amp;lt; 0.03). In SURDIAGENE, the association between the ACE I allele and renal outcome was not replicated. In DIAB2NEPHROGENE, no association was found with nephropathy.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014We were not able to demonstrate the manifest usefulness of the ACE insertion\/deletion polymorphism for the prognosis of type 2 diabetic subjects.<\/jats:p>","DOI":"10.2337\/dc07-2079","type":"journal-article","created":{"date-parts":[[2008,6,7]],"date-time":"2008-06-07T00:49:14Z","timestamp":1212799754000},"page":"1847-1852","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":67,"title":["Prognostic Value of the Insertion\/Deletion Polymorphism of the <i>ACE<\/i> Gene in Type 2 Diabetic Subjects"],"prefix":"10.2337","volume":"31","author":[{"given":"Samy","family":"Hadjadj","sequence":"first","affiliation":[{"name":"Centre Hospitalier Universitaire Poitiers, Endocrinology, Diabetology, Poitiers, France"},{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U927, Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fre\u0301de\u0301ric","family":"Fumeron","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U695, Paris, France"},{"name":"Unite\u0301 de Formation et de Recherche Me\u0301decine Xavier Bichat, Universite\u0301 Paris 7 Diderot, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronan","family":"Roussel","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U695, Paris, France"},{"name":"Unite\u0301 de Formation et de Recherche Me\u0301decine Xavier Bichat, Universite\u0301 Paris 7 Diderot, Paris, France"},{"name":"Endocrinologie-Diabetologie-Nutrition, Ho\u0302pital Bichat, Assistance Publique-Ho\u0302pitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Jean","family":"Saulnier","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Poitiers, France and Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, CIC 0802, Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Gallois","sequence":"additional","affiliation":[{"name":"Biochemistry, Centre Hospitalier Universitaire, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amos","family":"Ankotche","sequence":"additional","affiliation":[{"name":"Endocrinologie-Diabetologie-Nutrition, Ho\u0302pital Bichat, Assistance Publique-Ho\u0302pitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Travert","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U695, Paris, France"},{"name":"Unite\u0301 de Formation et de Recherche Me\u0301decine Xavier Bichat, Universite\u0301 Paris 7 Diderot, Paris, France"},{"name":"Endocrinologie-Diabetologie-Nutrition, Ho\u0302pital Bichat, Assistance Publique-Ho\u0302pitaux de Paris, Paris, France"},{"name":"CIC Bichat, Assistance Publique-Ho\u0302pitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charbel Abi","family":"Khalil","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U695, Paris, France"},{"name":"Unite\u0301 de Formation et de Recherche Me\u0301decine Xavier Bichat, Universite\u0301 Paris 7 Diderot, Paris, France"},{"name":"Endocrinologie-Diabetologie-Nutrition, Ho\u0302pital Bichat, Assistance Publique-Ho\u0302pitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aure\u0301lie","family":"Miot","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Poitiers, Endocrinology, Diabetology, Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franc\u0327ois","family":"Alhenc-Gelas","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U652, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Lievre","sequence":"additional","affiliation":[{"name":"Faculte\u0301 de Me\u0301decine Lae\u0308nnec, Universite\u0301 Claude Bernard Lyon 1, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Marre","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U695, Paris, France"},{"name":"Unite\u0301 de Formation et de Recherche Me\u0301decine Xavier Bichat, Universite\u0301 Paris 7 Diderot, Paris, France"},{"name":"Endocrinologie-Diabetologie-Nutrition, Ho\u0302pital Bichat, 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