{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T16:33:43Z","timestamp":1723394023016},"reference-count":24,"publisher":"American Diabetes Association","issue":"5","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":4573,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Because declines in acute insulin response (AIR) and insulin action (M) predict development of type 2 diabetes, we sought to determine childhood factors that predict insulin action and AIR using longitudinal data from young Pima Indian adults with normal glucose regulation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Predictors of adult M, measured by the euglycemic-hyperinsulinemic clamp, and AIR, measured after a 25-g glucose bolus, were assessed in 76 individuals from a set of childhood data (BMI, systolic blood pressure [sBP] and diastolic blood pressure, cholesterol, fasting and 2-h insulin, and glucose levels during an oral glucose tolerance test).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>After adjustment for sex, adult percent body fat, adult and childhood age, childhood BMI, and sBP were negative and independent predictors of adult M. A 5 kg\/m2 increase in childhood BMI was associated with a 7.4% decrease in adult insulin action (95% CI \u221212.7 to \u22121.8%, P = 0.01) and a 10-mmHg increase in childhood sBP with a 5.0% decrease in adult M (95% CI \u22128.4 to \u22121.4%, P = 0.007). After a similar adjustment with M as an additional covariate, childhood 2-h insulin was a positive predictor of adult AIR such that a 25% increase predicted a 7.3% increase in adult AIR (95% CI 1.5\u201313.5%, P = 0.014).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Childhood insulin response during an oral glucose challenge predicts adult AIR, indicating that \u03b2-cell capacity may be set early in life. Childhood measures related to adiposity predict adult insulin action, which may reflect common underlying mechanisms that may be amenable to modification through programs targeting prevention or treatment of childhood obesity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc08-1833","type":"journal-article","created":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T02:05:42Z","timestamp":1235095542000},"page":"938-943","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":13,"title":["Childhood Predictors of Adult Acute Insulin Response and Insulin Action"],"prefix":"10.2337","volume":"32","author":[{"given":"Marie S.","family":"Thearle","sequence":"first","affiliation":[{"name":"From the Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy C.","family":"Bunt","sequence":"additional","affiliation":[{"name":"From the Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Knowler","sequence":"additional","affiliation":[{"name":"From the Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Krakoff","sequence":"additional","affiliation":[{"name":"From the Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2009,2,19]]},"reference":[{"key":"2022031220092615500_B1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI7231","article-title":"The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus","volume":"104","author":"Weyer","year":"1999","journal-title":"J Clin Invest"},{"key":"2022031220092615500_B2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin","volume":"346","author":"Knowler","year":"2002","journal-title":"N Engl J Med"},{"key":"2022031220092615500_B3","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/S0140-6736(08)60766-7","article-title":"The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study","volume":"371","author":"Li","year":"2008","journal-title":"Lancet"},{"key":"2022031220092615500_B4","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/dmrr.686","article-title":"Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations","volume":"23","author":"Bunt","year":"2007","journal-title":"Diabete Metab Res Rev"},{"key":"2022031220092615500_B5","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.2337\/db06-1639","article-title":"Childhood predictors of young-onset type 2 diabetes","volume":"56","author":"Franks","year":"2007","journal-title":"Diabetes"},{"key":"2022031220092615500_B6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/oby.2005.21","article-title":"Weight status in childhood as a predictor of becoming overweight or hypertensive in early adulthood","volume":"13","author":"Field","year":"2005","journal-title":"Obes Res"},{"key":"2022031220092615500_B7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1067\/mpd.2001.112658","article-title":"Adiposity in childhood predicts obesity and insulin resistance in young adulthood","volume":"138","author":"Steinberger","year":"2001","journal-title":"J Pediatr"},{"key":"2022031220092615500_B8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1542\/peds.2006-2543","article-title":"Systolic blood pressure in childhood predicts hypertension and metabolic syndrome later in life","volume":"119","author":"Sun","year":"2007","journal-title":"Pediatrics"},{"key":"2022031220092615500_B9","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1515\/jpem-2001-0803","article-title":"Intrauterine diabetic environment confers risks for type 2 diabetes mellitus and obesity in the offspring, in addition to genetic susceptibility","volume":"14","author":"Dabelea","year":"2001","journal-title":"J Pediatr Endocrinol Metab"},{"key":"2022031220092615500_B10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/BF00403382","article-title":"Glucose, insulin concentrations and obesity in childhood and adolescence as predictors of NIDDM","volume":"37","author":"McCance","year":"1994","journal-title":"Diabetologia"},{"key":"2022031220092615500_B11","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.2337\/diacare.26.2007.S5","article-title":"Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","volume":"26","year":"2003","journal-title":"Diabetes Care"},{"key":"2022031220092615500_B12","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1056\/NEJM199312303292703","article-title":"Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: prospective studies of Pima Indians","volume":"329","author":"Lillioja","year":"1993","journal-title":"N Engl J Med"},{"key":"2022031220092615500_B13","doi-asserted-by":"crossref","first-page":"622","DOI":"10.2337\/diab.37.5.622","article-title":"Congenital susceptibility to NIDDM: role of intrauterine environment","volume":"37","author":"Pettitt","year":"1988","journal-title":"Diabetes"},{"key":"2022031220092615500_B14","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.2337\/diabetes.50.8.1828","article-title":"Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes","volume":"50","author":"Gautier","year":"2001","journal-title":"Diabetes"},{"key":"2022031220092615500_B15","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1210\/jcem-25-10-1375","article-title":"Coated charcoal immunoassay of insulin","author":"Herbert","year":"1965","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031220092615500_B16","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/ajcn\/62.4.730","article-title":"Use of dual-energy X-ray absorptiometry in obese individuals","volume":"62","author":"Tataranni","year":"1995","journal-title":"Am J Clin Nutr"},{"key":"2022031220092615500_B17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/dmr.5610040508","article-title":"Obesity and insulin resistance: lessons learned from the Pima Indians","volume":"4","author":"Lillioja","year":"1988","journal-title":"Diabetes Metab Rev"},{"key":"2022031220092615500_B18","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1002\/sim.4780111607","article-title":"A bootstrap resampling procedure for model building: application to the Cox regression model","volume":"11","author":"Sauerbrei","year":"1992","journal-title":"Stat Med"},{"key":"2022031220092615500_B19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1161\/01.HYP.0000226410.11198.f4","article-title":"Changes in metabolic syndrome variables since childhood in prehypertensive and hypertensive subjects: the Bogalusa Heart Study","volume":"48","author":"Srinivasan","year":"2006","journal-title":"Hypertension"},{"key":"2022031220092615500_B20","doi-asserted-by":"crossref","first-page":"204","DOI":"10.2337\/diabetes.51.1.204","article-title":"Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study","volume":"51","author":"Srinivasan","year":"2002","journal-title":"Diabetes"},{"key":"2022031220092615500_B21","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1177\/174182679600300503","article-title":"Association of body mass index, blood pressure and serum levels of triglycerides and high-density lipoprotein cholesterol in childhood with the insulin sensitivity index in young adulthood: a 13-year follow-up","volume":"3","author":"Clausen","year":"1996","journal-title":"J Cardiovasc Risk"},{"key":"2022031220092615500_B22","article-title":"Multivariable Analysis: A Practical Guide for Clinicians","author":"Katz","year":"2006","edition":"2nd ed"},{"key":"2022031220092615500_B23","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1210\/jcem.86.9.7760","article-title":"Body mass index as a measure of adiposity in children and adolescents: relationship to adiposity by dual energy X-ray absorptiometry and to cardiovascular risk factors","volume":"86","author":"Lindsay","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031220092615500_B24","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/j.1464-5491.2004.01290.x","article-title":"Exaggerated insulin secretion in Pima Indians and African-Americans but higher insulin resistance in Pima Indians compared to African-Americans and Caucasians","volume":"21","author":"Stefan","year":"2004","journal-title":"Diabet Med"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/32\/5\/938\/601101\/zdc00509000938.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/32\/5\/938\/601101\/zdc00509000938.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T21:57:24Z","timestamp":1647122244000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/32\/5\/938\/29666\/Childhood-Predictors-of-Adult-Acute-Insulin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,19]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,2,19]]},"published-print":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc08-1833","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,19]]}}}