{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:59:09Z","timestamp":1788325149781,"version":"build-2803163510"},"reference-count":12,"publisher":"American Diabetes Association","issue":"4","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":4615,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Impaired muscular mitochondrial function is related to common insulin resistance in type 2 diabetes. Mitochondrial diseases frequently lead to diabetes, which is mostly attributed to defective \u03b2-cell mitochondria and secretion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>We assessed muscular mitochondrial function and lipid deposition in liver (hepatocellular lipids [HCLs]) and muscle (intramyocellular lipids [IMCLs]) using 31P\/1H magnetic resonance spectroscopy and insulin sensitivity and endogenous glucose production (EGP) using hyperinsulinemic-euglycemic clamps combined with isotopic tracer dilution in one female patient suffering from MELAS (myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) syndrome and in six control subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The MELAS patient showed impaired insulin sensitivity (4.3 vs. 8.6 \u00b1 0.5 mg \u00b7 kg\u22121 \u00b7 min\u22121) and suppression of EGP (69 vs. 94 \u00b1 1%), and her baseline and insulin-stimulated ATP synthesis were reduced (7.3 and 8.9 vs. 10.6 \u00b1 1.0 and 12.8 \u00b1 1.3 \u03bcmol \u00b7 l\u22121 \u00b7 min\u22121) compared with those of the control subjects. HCLs and IMCLs were comparable between the MELAS patient and control subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Impairment of muscle mitochondrial fitness promotes insulin resistance and could thereby contribute to the development of diabetes in some patients with the MELAS syndrome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc08-2078","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T01:56:08Z","timestamp":1231466168000},"page":"677-679","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":67,"title":["Impaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes"],"prefix":"10.2337","volume":"32","author":[{"given":"Julia","family":"Szendroedi","sequence":"first","affiliation":[{"name":"First Medical Department and Karl-Landsteiner Institute for Endocrinology and Metabolism, Hanusch Hospital, Vienna, Austria;"},{"name":"Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center, Department of Medicine\/Metabolic Diseases, Heinrich-Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht Ingo","family":"Schmid","sequence":"additional","affiliation":[{"name":"First Medical Department and Karl-Landsteiner Institute for Endocrinology and Metabolism, Hanusch Hospital, Vienna, Austria;"},{"name":"MR Centre of Excellence, Medical University of Vienna, Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Meyerspeer","sequence":"additional","affiliation":[{"name":"MR Centre of Excellence, Medical University of Vienna, Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Cervin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Kacerovsky","sequence":"additional","affiliation":[{"name":"First Medical Department and Karl-Landsteiner Institute for Endocrinology and Metabolism, Hanusch Hospital, Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Smekal","sequence":"additional","affiliation":[{"name":"Department of Sport Physiology, Institute of Sports Sciences, University of Vienna, Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Gr\u00e4ser-Lang","sequence":"additional","affiliation":[{"name":"Neurological Outpatient Service, Hanusch Hospital, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Groop","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roden","sequence":"additional","affiliation":[{"name":"First Medical Department and Karl-Landsteiner Institute for Endocrinology and Metabolism, Hanusch Hospital, Vienna, Austria;"},{"name":"Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center, Department of Medicine\/Metabolic Diseases, Heinrich-Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2009,1,8]]},"reference":[{"key":"2022031219582932300_B1","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.2337\/db06-S002","article-title":"Molecular mechanisms of insulin resistance in humans and their potential 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