{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:49:48Z","timestamp":1792842588144,"version":"4.5.0"},"reference-count":25,"publisher":"American Diabetes Association","issue":"8","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":4509,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Increased serum ferritin levels and iron stores may be involved in the development of abnormal glucose tolerance in women presenting with obesity and\/or polycystic ovary syndrome (PCOS). We aimed to study the determinants of serum ferritin levels in premenopausal women among indexes of insulin resistance, adiposity, hyperandrogenism, and genotypes pertaining to inflammation, oxidative stress, and iron metabolism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>A total of 257 premenopausal women, classified depending on the presence or absence of PCOS, obesity, and\/or abnormal glucose tolerance, underwent a complete metabolic evaluation, serum ferritin, haptoglobin, and C-reactive protein (CRP) measurements, and genotyping for proinflammatory and prooxidant variants and mutations in the HFE gene.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Serum ferritin concentrations were increased in women presenting with PCOS and\/or abnormal glucose tolerance, independent of obesity. A stepwise multivariate linear regression analysis (R2 = 0.18, P &amp;lt; 0.0001) retained menstrual dysfunction (\u03b2 = 0.14, P = 0.035), free testosterone (\u03b2 = 0.14, P = 0.052), insulin sensitivity index (\u03b2 = \u22120.12, P = 0.012), the His63Asp variant in HFE (\u03b2 = 0.16, P = 0.008), and abnormal glucose tolerance (\u03b2 = 0.15, P = 0.015) as significant predictors of the logarithm of ferritin levels, whereas CRP, haptoglobin, waist-to-hip ratio, or variants in the TNF\u03b1, TNFRSF1B, IL6, IL6ST, IL6R\u03b1, PON1, and HFE Cys282Tyr mutation exerted no influence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Androgen excess (partly because of hyperandrogenemia and partly because of menstrual dysfunction), insulin resistance, abnormal glucose tolerance, and the HFE His63Asp variant correlate with ferritin levels in premenopausal women.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc09-0420","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T01:33:37Z","timestamp":1240968817000},"page":"1525-1530","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":66,"title":["Body Iron Stores and Glucose Intolerance in Premenopausal Women"],"prefix":"10.2337","volume":"32","author":[{"given":"M. \u00c1ngeles","family":"Mart\u00ednez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Ram\u00f3n y Cajal and Universidad de Alcal\u00e1, Madrid, Spain and Centro de Investigaciones Biom\u00e9dicas en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Luque-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Ram\u00f3n y Cajal and Universidad de Alcal\u00e1, Madrid, Spain and Centro de Investigaciones Biom\u00e9dicas en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"San-Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Hospital Universitario Ram\u00f3n y Cajal and Universidad de Alcal\u00e1, Madrid, Spain and Centro de Investigaciones Biom\u00e9dicas en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor F.","family":"Escobar-Morreale","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Ram\u00f3n y Cajal and Universidad de Alcal\u00e1, Madrid, Spain and Centro de Investigaciones Biom\u00e9dicas en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas, Barcelona, 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