{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:47:13Z","timestamp":1777571233131,"version":"3.51.4"},"reference-count":11,"publisher":"American Diabetes Association","issue":"11","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":4413,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To examine the relationship between birth weight and abdominal adiposity in adolescents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>A total of 284 adolescents (49.3% of whom were female) aged 14.9 \u00b1 1.2 years were included in the study. Birth weight and gestational age were obtained from parental records. Abdominal adiposity (in three regions: R1, R2, and R3) and trunk and total body fat mass were measured by dual-energy X-ray absorptiometry. Regional fat mass indexes (FMIs) were thereafter calculated as fat mass divided by the square of height (Trunk FMI and abdominal FMI R1, R2, and R3).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Birth weight was negatively associated with abdominal FMI R1, R2, and R3 independently of total fat mass, gestational age, sex, breast-feeding duration, pubertal stage, physical activity, and socioeconomic status (all P &amp;lt; 0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Our study shows an inverse association between birth weight and abdominal adiposity in adolescents independently of total fat mass and other potential confounders. These findings suggest that fetal nutrition, as reflected by birth weight, may have a programming effect on abdominal adiposity later in life.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc09-0983","type":"journal-article","created":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T01:59:09Z","timestamp":1248919149000},"page":"2120-2122","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":42,"title":["Early Life Programming of Abdominal Adiposity in Adolescents: The HELENA Study"],"prefix":"10.2337","volume":"32","author":[{"given":"Idoia","family":"Labayen","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonatan R.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Unit for Preventive Nutrition, the Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germ\u00e1n","family":"Vicente-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"University School of Health Sciences, University of Zaragoza, Zaragoza, Spain;"},{"name":"Department of Physiotherapy and Nursing, University of Zaragoza, Huesca, Spain;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Turck","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Lille, and Department of Pediatrics, Jeanne de Flandre Children's University Hospital, Lille, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"University School of Health Sciences, University of Zaragoza, Zaragoza, Spain;"},{"name":"Department of Pediatrics, University of Zaragoza, Zaragoza, Spain, and the Instituto Aragon\u00e9s de Ciencias de la Salud, Zaragoza, Spain;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Meirhaeghe","sequence":"additional","affiliation":[{"name":"INSERM, U744, Institut Pasteur de Lille, Lille, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denes","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Pecs, P\u00e9cs-J\u00f3zsef, Hungary;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sj\u00f6str\u00f6m","sequence":"additional","affiliation":[{"name":"Unit for Preventive Nutrition, the Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel J.","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, School of Medicine, University of Granada, Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Gottrand","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Lille, and Department of Pediatrics, Jeanne de Flandre Children's University Hospital, Lille, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Moreno","sequence":"additional","affiliation":[{"name":"University School of Health Sciences, University of Zaragoza, Zaragoza, Spain;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2009,7,29]]},"reference":[{"key":"2022031218170286700_B1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(98)07546-1","article-title":"The fetal insulin 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