{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:25:11Z","timestamp":1790324711784,"version":"4.1.0"},"reference-count":15,"publisher":"American Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":4337,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To compare risks of lower-extremity amputation between patients with Charcot arthropathy and those with diabetic foot ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>A retrospective cohort of patients with incident Charcot arthropathy or diabetic foot ulcers in 2003 was followed for 5 years for any major and minor amputations in the lower extremities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>After a mean follow-up of 37 \u00b1 20 and 43 \u00b1 18 months, the Charcot and ulcer groups had 4.1 and 4.7 amputations per 100 person-years, respectively. Among patients &amp;lt;65 years old at the end of follow-up, amputation risk relative to patients with Charcot alone was 7 times higher for patients with ulcer alone and 12 times higher for patients with Charcot and ulcer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Charcot arthropathy by itself does not pose a serious amputation risk, but ulcer complication multiplicatively increases the risk. Early surgical intervention for Charcot patients in the absence of deformity or ulceration may not be advisable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc09-1497","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T02:56:44Z","timestamp":1255489004000},"page":"98-100","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":189,"title":["Lower-Extremity Amputation Risk After Charcot Arthropathy and Diabetic Foot Ulcer"],"prefix":"10.2337","volume":"33","author":[{"given":"Min-Woong","family":"Sohn","sequence":"first","affiliation":[{"name":"Center for Management of Complex Chronic Care, Hines Veterans Affairs Hospital, Hines, Illinois;"},{"name":"Institute for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney M.","family":"Stuck","sequence":"additional","affiliation":[{"name":"Surgical Service, Hines Veterans Affairs Hospital, Hines, Illinois;"},{"name":"Department of Orthopedic Surgery, Loyola University Stritch School of Medicine, Maywood, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pinzur","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Loyola University Stritch School of Medicine, Maywood, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Management of Complex Chronic Care, Hines Veterans Affairs Hospital, Hines, Illinois;"},{"name":"Center for Pharmacoeconomic Research, Departments of Pharmacy Practice and Pharmacy Administration, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elly","family":"Budiman-Mak","sequence":"additional","affiliation":[{"name":"Center for Management of Complex Chronic Care, Hines Veterans Affairs Hospital, Hines, Illinois;"},{"name":"Department of Medicine, Loyola University Stritch School of Medicine, Maywood, Illinois."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2009,10,13]]},"reference":[{"key":"2022031219421304700_B1","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2337\/diacare.22.7.1029","article-title":"Lower-extremity amputation in diabetes: the independent effects of peripheral vascular disease, sensory neuropathy, and foot ulcers","volume":"22","author":"Adler","year":"1999","journal-title":"Diabetes Care"},{"key":"2022031219421304700_B2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.7547\/87507315-87-6-255","article-title":"Amputation and reamputation of the 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