{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:24:43Z","timestamp":1790367883978,"version":"4.1.0"},"reference-count":19,"publisher":"American Diabetes Association","issue":"4","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":4260,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To determine the effect of total parenteral nutrition (TPN)-induced hyperglycemia on hospital outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>The study determined whether blood glucose values before, within 24 h, and during days 2\u201310 of TPN are predictive of hospital complications and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Subjects included a total of 276 patients receiving TPN for a mean duration of 15 \u00b1 24 days (\u00b1SD). In multiple regression models adjusted for age, sex, and diabetes status, mortality was independently predicted by pre-TPN blood glucose of 121\u2013150 mg\/dl (odds ratio [OR] 2.2, 95% CI 1.1\u20134.4, P = 0.030), 151\u2013180 mg\/dl (3.41, 1.3\u20138.7, P = 0.01), and &amp;gt;180 mg\/dl (2.2, 0.9\u20135.2, P = 0.077) and by blood glucose within 24 h of &amp;gt;180 mg\/dl (2.8, 1.2\u20136.8, P = 0.020). A blood glucose within 24 h of &amp;gt;180 mg\/dl was associated with increased risk of pneumonia (OR 3.1, 95% CI 1.4\u20137.1) and acute renal failure (2.3, 1.1\u20135.0).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Hyperglycemia is associated with increased hospital complications and mortality in patients receiving TPN.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc09-1748","type":"journal-article","created":{"date-parts":[[2009,12,30]],"date-time":"2009-12-30T01:44:26Z","timestamp":1262137466000},"page":"739-741","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":121,"title":["Hyperglycemia During Total Parenteral Nutrition"],"prefix":"10.2337","volume":"33","author":[{"given":"Francisco J.","family":"Pasquel","sequence":"first","affiliation":[{"name":"Department of Medicine, Emory University School of 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