{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:26:08Z","timestamp":1780431968541,"version":"3.54.1"},"reference-count":13,"publisher":"American Diabetes Association","issue":"10","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":4061,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Serum insulin-like growth factor (IGF)-1 may have a role in the maintenance of glucose homeostasis. We examined the association between serum IGF-1 and diabetes in a representative sample of U.S. adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Third National Health and Nutrition Examination Survey (NHANES III) participants aged \u226518 years (n = 5,511) were the subjects of the study. The main outcome was the presence of diabetes (n = 387).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Lower serum IGF-1 levels were positively associated with diabetes after adjusting for age, sex, race\/ethnicity, education, smoking, alcohol intake, BMI, hypertension, glomerular filtration rate, and serum cholesterol. Compared with quartile 4 of IGF-1 (referent), the odds ratio (OR) of diabetes associated with quartile 1 was OR 2.16 (95% CI 1.24\u20133.76); P-trend = 0.002. However, the observed association between IGF-1 and diabetes was present only in those &amp;lt;65 years of age (OR = 3.05; P-trend = 0.006) and disappeared in those \u226565 years of age (OR = 0.51; P-trend = 0.18); P-interaction = 0.0056.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Low IGF-1 levels are associated with diabetes among young subjects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc10-0770","type":"journal-article","created":{"date-parts":[[2010,7,17]],"date-time":"2010-07-17T02:29:23Z","timestamp":1279333763000},"page":"2257-2259","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":121,"title":["Association Between Serum IGF-1 and Diabetes Among U.S. Adults"],"prefix":"10.2337","volume":"33","author":[{"given":"Srinivas","family":"Teppala","sequence":"first","affiliation":[{"name":"From the Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Shankar","sequence":"additional","affiliation":[{"name":"From the Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2010,7,16]]},"reference":[{"key":"2022031218494833600_B1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev.ph.47.030185.002303","article-title":"Actions of insulin-like growth factors","volume":"47","author":"Froesch","year":"1985","journal-title":"Annu Rev Physiol"},{"key":"2022031218494833600_B2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1056\/NEJM199702273360907","article-title":"Seminars in medicine of the Beth Israel Deaconess Medical Center: insulin-like growth factors","volume":"336","author":"Le Roith","year":"1997","journal-title":"N Engl J Med"},{"key":"2022031218494833600_B3","first-page":"77","article-title":"Role of insulin-like growth factor in maintaining normal glucose homeostasis","volume":"62","author":"Clemmons","year":"2004","journal-title":"Horm Res"},{"key":"2022031218494833600_B4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/dmrr.919","article-title":"The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes","volume":"25","author":"Rajpathak","year":"2009","journal-title":"Diabete Metab Res Rev"},{"key":"2022031218494833600_B5","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.2337\/diacare.27.11.2682","article-title":"The impact of abnormalities in IGF and inflammatory systems on the metabolic syndrome","volume":"27","author":"Kaushal","year":"2004","journal-title":"Diabetes Care"},{"key":"2022031218494833600_B6","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ghir.2007.08.004","article-title":"Insulin-like growth factor-(IGF)-axis, inflammation, and glucose intolerance among older adults","volume":"18","author":"Rajpathak","year":"2008","journal-title":"Growth Horm IGF Res"},{"key":"2022031218494833600_B7","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/S0140-6736(02)08655-5","article-title":"Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study","volume":"359","author":"Sandhu","year":"2002","journal-title":"Lancet"},{"key":"2022031218494833600_B8","unstructured":"National Center for Health Statistics. Analytic and Reporting Guidelines: NHANES III [article online], 1996. Available at www.cdc.gov\/nchs\/data\/nhanes\/nhanes3\/nh3gui\/pdf. Accessed 23 November 2009"},{"key":"2022031218494833600_B9","unstructured":"National Center for Health Statistics. Laboratory Procedures Used for NHANES III [article online], 1996. Available at ftp:\/\/ftp.cdc.gov\/pub\/Health_Statistics\/NCHS\/Datasets\/NHANES\/NHANESIII\/1A\/lab-acc.pdf. Accessed 23 November 2009"},{"key":"2022031218494833600_B10","unstructured":"National Center for Health Statistics. Surplus Sera Laboratory Component: Insulin Like Growth Factor [article online], 2006. Available at ftp:\/\/ftp.cdc.gov\/pub\/Health_Statistics\/NCHS\/Datasets\/NHANES\/NHANESIII\/23a\/SSIGF.pdf. Accessed 23 November 2009"},{"key":"2022031218494833600_B11","unstructured":"National Center for Health Statistics. The Third National Health and Nutrition Examination Survey: Reference Manuals and Reports [article online], 2006. Available at: http:\/\/www.cdc.gov\/nchs\/products\/elec_prods\/subject\/han3rom.htm. Accessed 23 November 2009"},{"key":"2022031218494833600_B12","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1210\/er.2001-0033","article-title":"Cellular actions of the insulin-like growth factor binding proteins","volume":"23","author":"Firth","year":"2002","journal-title":"Endocr Rev"},{"key":"2022031218494833600_B13","doi-asserted-by":"crossref","first-page":"6588","DOI":"10.1210\/jc.2005-0595","article-title":"Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes","volume":"90","author":"Chan","year":"2005","journal-title":"J Clin Endocrinol Metab"}],"updated-by":[{"DOI":"10.2337\/dc17-er08","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000}}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/33\/10\/2257\/604908\/zdc01010002257.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/33\/10\/2257\/604908\/zdc01010002257.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T19:57:37Z","timestamp":1647115057000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/33\/10\/2257\/27875\/Association-Between-Serum-IGF-1-and-Diabetes-Among"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,16]]},"references-count":13,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2010,7,16]]},"published-print":{"date-parts":[[2010,10,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc10-0770","relation":{"correction":[{"id-type":"doi","id":"10.2337\/dc17-er08","asserted-by":"object"}]},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,16]]}}}