{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:54:00Z","timestamp":1783137240128,"version":"3.54.6"},"reference-count":15,"publisher":"American Diabetes Association","issue":"8","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":3696,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To study the relation between metabolic syndrome (MS), cavernosal morphological vasculopathy, and peripheral vascular alterations (carotid and femoral wall) in patients with erectile dysfunction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>A total of 207 patients and 50 control subjects were evaluated for cardiovascular risk factors, physical examination, reproductive hormones, ultrasound analysis of cavernosal, carotid and femoral arteries (intima-media thickness), and cavernosal flow measurement (peak systolic velocity).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 28% of patients had MS, and they presented with a high prevalence of cavernosal alterations (70.3%) and systemic vascular impairment (59.3%), whereas patients with cavernosal alterations (44%) showed the higher prevalence of MS (48.9%). The number of MS components was related to the prevalence of penile vasculopathy. However, multivariate analysis showed that MS is not an independent predictor for cavernosal vasculopathy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Patients with cavernosal vasculopathy have an increased cardiometabolic risk, and screening for MS components might identify individuals with a higher risk for cavernosal and systemic atherosclerosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc11-0070","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T04:21:35Z","timestamp":1309926095000},"page":"1875-1877","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":12,"title":["Metabolic Syndrome and Erectile Dysfunction"],"prefix":"10.2337","volume":"34","author":[{"given":"Mirko","family":"Schipilliti","sequence":"first","affiliation":[{"name":"Department of Histology, Microbiology, and Medical Biotechnologies, Section of Clinical Pathology, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Caretta","sequence":"additional","affiliation":[{"name":"Department of Histology, Microbiology, and Medical Biotechnologies, Section of Clinical Pathology, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierfrancesco","family":"Palego","sequence":"additional","affiliation":[{"name":"Department of Histology, Microbiology, and Medical Biotechnologies, Section of Clinical Pathology, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Selice","sequence":"additional","affiliation":[{"name":"Department of Histology, Microbiology, and Medical Biotechnologies, Section of Clinical Pathology, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Ferlin","sequence":"additional","affiliation":[{"name":"Department of Histology, Microbiology, and Medical Biotechnologies, Section of Clinical Pathology, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Foresta","sequence":"additional","affiliation":[{"name":"Department of Histology, Microbiology, and Medical Biotechnologies, Section of Clinical Pathology, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2011,7,16]]},"reference":[{"key":"2022031219182117300_B1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1365-2605.2008.00932.x","article-title":"Clinical and metabolic evaluation of subjects with erectile dysfunction: a review with a proposal flowchart","volume":"32","author":"Foresta","year":"2009","journal-title":"Int J Androl"},{"key":"2022031219182117300_B2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/01.mou.0000250284.83108.a6","article-title":"Cardiovascular disease, metabolic syndrome and erectile dysfunction","volume":"16","author":"M\u00fcller","year":"2006","journal-title":"Curr Opin Urol"},{"key":"2022031219182117300_B3","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.eururo.2007.08.004","article-title":"Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: common links","volume":"52","author":"Vlachopoulos","year":"2007","journal-title":"Eur Urol"},{"key":"2022031219182117300_B4","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.juro.2006.09.043","article-title":"Is the metabolic syndrome an independent risk factor for erectile dysfunction?","volume":"177","author":"Heidler","year":"2007","journal-title":"J Urol"},{"key":"2022031219182117300_B5","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"2022031219182117300_B6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.eururo.2005.01.013","article-title":"Resumption of spontaneous erections in selected patients affected by erectile dysfunction and various degrees of carotid wall alteration: role of tadalafil","volume":"48","author":"Caretta","year":"2005","journal-title":"Eur Urol"},{"key":"2022031219182117300_B7","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/sj.ijir.3901413","article-title":"Age-matched cavernous peak systolic velocity: a highly sensitive parameter in the diagnosis of arteriogenic erectile dysfunction","volume":"18","author":"Caretta","year":"2006","journal-title":"Int J Impot Res"},{"key":"2022031219182117300_B8","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.atherosclerosis.2007.08.006","article-title":"Asymmetric development of peripheral atherosclerosis in patients with erectile dysfunction: an ultrasonographic study","volume":"197","author":"Foresta","year":"2008","journal-title":"Atherosclerosis"},{"key":"2022031219182117300_B9","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1111\/j.1743-6109.2010.01779.x","article-title":"Cardiovascular aspects of sexual medicine","volume":"7","author":"Jackson","year":"2010","journal-title":"J Sex Med"},{"key":"2022031219182117300_B10","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/j.1743-6109.2008.01112.x","article-title":"Cavernous artery intima-media thickness: a new parameter in the diagnosis of vascular erectile dysfunction","volume":"6","author":"Caretta","year":"2009","journal-title":"J Sex Med"},{"key":"2022031219182117300_B11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1743-6109.2009.01576.x","article-title":"Erectile dysfunction as a predictor for subsequent atherosclerotic cardiovascular events: findings from a linked-data study","volume":"7","author":"Chew","year":"2010","journal-title":"J Sex Med"},{"key":"2022031219182117300_B12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000200795","article-title":"Penile vascular impairment in erectile dysfunction patients with metabolic syndrome: penile Doppler ultrasound findings","volume":"82","author":"Demir","year":"2009","journal-title":"Urol Int"},{"key":"2022031219182117300_B13","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1200\/JCO.2004.99.556","article-title":"Cavernosal arterial insufficiency and metabolic syndrome probably represent a common pathology of endothelial dysfunction in recipients of high-dose therapy and stem-cell transplantation","volume":"22","author":"Chatterjee","year":"2004","journal-title":"J Clin Oncol"},{"key":"2022031219182117300_B14","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.atherosclerosis.2010.02.006","article-title":"The metabolic syndrome predicts carotid intima-media thickness no better than the sum of individual risk factors in a lipid clinic population","volume":"210","author":"Baldassarre","year":"2010","journal-title":"Atherosclerosis"},{"key":"2022031219182117300_B15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.2337\/diacare.28.4.882","article-title":"The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the Cardiovascular Health Study","volume":"28","author":"Scuteri","year":"2005","journal-title":"Diabetes Care"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/34\/8\/1875\/609601\/1875.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/34\/8\/1875\/609601\/1875.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T20:44:43Z","timestamp":1647117883000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/34\/8\/1875\/27540\/Metabolic-Syndrome-and-Erectile-DysfunctionThe"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,16]]},"references-count":15,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2011,7,16]]},"published-print":{"date-parts":[[2011,8,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc11-0070","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,16]]}}}