{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T03:01:20Z","timestamp":1772852480771,"version":"3.50.1"},"reference-count":25,"publisher":"American Diabetes Association","issue":"12","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Observational studies have yielded inconsistent findings regarding the association of hemoglobin A1c (HbA1c) with survival in diabetic patients on dialysis. The association between pretransplant glycemic control and short- and long-term posttransplant outcomes in kidney transplant recipients is not clear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Linking the 5-year patient data of a large dialysis organization (DaVita) to the Scientific Registry of Transplant Recipients, we identified 2,872 diabetic dialysis patients who underwent first kidney transplantation. Mortality or graft failure and delayed graft function (DGF) risks were estimated by Cox regression (hazard ratio [HR]) and logistic regression (odds ratio), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Patients were 53 \u00b1 11 years old and included 36% women and 24% African Americans. In our fully adjusted model, allograft failure\u2013censored, all-cause death HR and 95% CI for time-averaged pretransplant HbA1c categories of 7 to &amp;lt;8%, 8 to &amp;lt;9%, 9 to 10%, and \u226510%, compared with 6 to &amp;lt;7% (reference), were 0.89 (0.59\u20131.36), 2.06 (1.31\u20133.24), 1.41 (0.73\u20132.74), and 3.43 (1.56\u20137.56), respectively; and graft failure\u2013censored cardiovascular death HR was 0.38 (0.13\u20131.05), 1.78 (0.69\u20134.55), 1.59 (0.44\u20135.76), and 4.28 (0.85\u201321.64), respectively. We did not find any difference in risk of death-censored graft failure or DGF with different pretransplant HbA1c levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Poor pretransplant glycemic control appears associated with decreased posttransplant survival in kidney transplant recipients, whereas allograft outcomes may not be affected.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc11-0906","type":"journal-article","created":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T01:00:17Z","timestamp":1318554017000},"page":"2536-2541","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":31,"title":["Association of Pretransplant Glycemic Control With Posttransplant Outcomes in Diabetic Kidney Transplant Recipients"],"prefix":"10.2337","volume":"34","author":[{"given":"Miklos Z.","family":"Molnar","sequence":"first","affiliation":[{"name":"Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California"},{"name":"Institute of Pathophysiology, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund","family":"Huang","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine at UCLA, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California"},{"name":"Department of Epidemiology, UCLA School of Public Health, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh","family":"Krishnan","sequence":"additional","affiliation":[{"name":"DaVita, Inc., Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen R.","family":"Nissenson","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine at UCLA, Los Angeles, California"},{"name":"DaVita, Inc., Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba P.","family":"Kovesdy","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Salem VA Medical Center, Salem, Virginia"},{"name":"Division of Nephrology, University of Virginia, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamyar","family":"Kalantar-Zadeh","sequence":"additional","affiliation":[{"name":"Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California"},{"name":"David Geffen School of Medicine at UCLA, Los Angeles, California"},{"name":"Department of Epidemiology, UCLA School of Public Health, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2011,11,14]]},"reference":[{"key":"2022031302585161500_B1","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1053\/j.ajkd.2010.06.027","article-title":"Associations of pretransplant diabetes mellitus, new-onset diabetes after transplant, and acute rejection with transplant outcomes: an analysis of the Organ Procurement and Transplant Network\/United Network for Organ Sharing (OPTN\/UNOS) database","volume":"56","author":"Kuo","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"2022031302585161500_B2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1056\/NEJMoa021778","article-title":"Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes","volume":"348","author":"Gaede","year":"2003","journal-title":"N Engl J Med"},{"key":"2022031302585161500_B3","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1056\/NEJM199505113321915","article-title":"Glycosylated hemoglobin and the risk of retinopathy in insulin-dependent diabetes mellitus","volume":"332","author":"Warram","year":"1995","journal-title":"N Engl J Med"},{"key":"2022031302585161500_B4","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJM199309303291401","article-title":"The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus","volume":"329","author":"The Diabetes Control and Complications Trial Research Group","year":"1993","journal-title":"N Engl J Med"},{"key":"2022031302585161500_B5","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.2337\/dc10-S011","article-title":"Standards of medical care in diabetes\u20142010","volume":"33","author":"American Diabetes Association","year":"2010","journal-title":"Diabetes Care"},{"key":"2022031302585161500_B6","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for cardiovascular disease in dialysis patients","volume":"45","author":"K\/DOQI Workgroup","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"2022031302585161500_B7","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/sj.ki.5001789","article-title":"Hemodialyzed type I and type II diabetic patients in the US: characteristics, glycemic control, and survival","volume":"70","author":"Williams","year":"2006","journal-title":"Kidney Int"},{"key":"2022031302585161500_B8","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1053\/j.ajkd.2006.12.005","article-title":"KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease","volume":"49","author":"KDOQI","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"2022031302585161500_B9","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1056\/NEJMoa0802987","article-title":"Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes","volume":"358","author":"Patel","year":"2008","journal-title":"N Engl J Med"},{"key":"2022031302585161500_B10","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2215\/CJN.09301209","article-title":"Glycemic control and extended hemodialysis survival in patients with diabetes mellitus: comparative results of traditional and time-dependent Cox model analyses","volume":"5","author":"Williams","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"2022031302585161500_B11","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.2215\/CJN.04410510","article-title":"Hemoglobin A1c in hemodialysis patients: should one size fit all?","volume":"5","author":"Ix","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"2022031302585161500_B12","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1053\/j.ajkd.2009.12.038","article-title":"Glycemic control and the risk of death in 1,484 patients receiving maintenance hemodialysis","volume":"55","author":"Shurraw","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"2022031302585161500_B13","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.2337\/dc06-2127","article-title":"A1C and survival in maintenance hemodialysis patients","volume":"30","author":"Kalantar-Zadeh","year":"2007","journal-title":"Diabetes Care"},{"key":"2022031302585161500_B14","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.2215\/CJN.08921010","article-title":"Glycemic control and survival in peritoneal dialysis patients with diabetes mellitus","volume":"6","author":"Duong","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"2022031302585161500_B15","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/j.1600-6143.2011.03480.x","article-title":"Associations of pretransplant serum albumin with post-transplant outcomes in kidney transplant recipients","volume":"11","author":"Molnar","year":"2011","journal-title":"Am J Transplant"},{"key":"2022031302585161500_B16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1525-139X.2010.00701.x","article-title":"Glycemic control and burnt-out diabetes in ESRD","volume":"23","author":"Kovesdy","year":"2010","journal-title":"Semin Dial"},{"key":"2022031302585161500_B17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1053\/j.jrn.2008.11.012","article-title":"Burnt-out diabetes: impact of chronic kidney disease progression on the natural course of diabetes mellitus","volume":"19","author":"Kalantar-Zadeh","year":"2009","journal-title":"J Ren Nutr"},{"key":"2022031302585161500_B18","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1681\/ASN.2005050552","article-title":"Glycosylated hemoglobin and mortality in patients with nondiabetic chronic kidney disease","volume":"16","author":"Menon","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"2022031302585161500_B19","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1093\/ndt\/12.10.2105","article-title":"Poor pre-dialysis glycaemic control is a predictor of mortality in type II diabetic patients on maintenance haemodialysis","volume":"12","author":"Wu","year":"1997","journal-title":"Nephrol Dial Transplant"},{"key":"2022031302585161500_B20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1034\/j.1600-6143.2003.00010.x","article-title":"Diabetes mellitus after kidney transplantation in the United States","volume":"3","author":"Kasiske","year":"2003","journal-title":"Am J Transplant"},{"key":"2022031302585161500_B21","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/01.tp.0000259617.21741.95","article-title":"Diabetic complications associated with new-onset diabetes mellitus in renal transplant recipients","volume":"83","author":"Burroughs","year":"2007","journal-title":"Transplantation"},{"key":"2022031302585161500_B22","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1093\/ndt\/gfm067","article-title":"Glycated haemoglobin levels are related to chronic subclinical inflammation in renal transplant recipients without pre-existing or new onset diabetes","volume":"22","author":"Porrini","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"2022031302585161500_B23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1053\/j.ajkd.2010.11.027","article-title":"Association of the malnutrition-inflammation score with clinical outcomes in kidney transplant recipients","volume":"58","author":"Molnar","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"2022031302585161500_B24","doi-asserted-by":"crossref","first-page":"814","DOI":"10.2215\/CJN.04681107","article-title":"Impact of acute rejection and new-onset diabetes on long-term transplant graft and patient survival","volume":"3","author":"Cole","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"2022031302585161500_B25","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.2215\/CJN.04210511","article-title":"Assessment of glycemic control in dialysis patients with diabetes: glycosylated hemoglobin or glycated albumin?","volume":"6","author":"Mehrotra","year":"2011","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/34\/12\/2536\/607341\/2536.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/34\/12\/2536\/607341\/2536.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T07:16:52Z","timestamp":1647155812000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/34\/12\/2536\/39055\/Association-of-Pretransplant-Glycemic-Control-With"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,14]]},"references-count":25,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,11,14]]},"published-print":{"date-parts":[[2011,12,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc11-0906","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,14]]}}}