{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:48:48Z","timestamp":1793155728960,"version":"4.5.0"},"reference-count":19,"publisher":"American Diabetes Association","issue":"2","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":3516,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Gain-of-function ABCC8\/sulfonylurea (SU) receptor 1 mutations cause neonatal diabetes mellitus (NDM) or late-onset diabetes in adult relatives. Given the effectiveness of SU treatment in ABCC8-NDM patients, we further characterized late-onset ABCC8-associated diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Seven adult subjects from three NDM families and one family with type 2 diabetes were studied. Insulin secretion and insulin sensitivity were assessed using clamp techniques. We screened 139 type 2 diabetic patients who were well controlled by SU for ABCC8 mutations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>ABCC8 mutation carriers exhibited glucose intolerance, frank diabetes, or insulin-requiring diabetes since diagnosis. HbA1c improved in five SU-treated patients. Insulin secretion capacity was impaired in three patients compared with adult control subjects but was restored after a 4-week SU trial in two patients. Cohort screening revealed four SU-treated patients with ABCC8 mutations, two of which are likely causal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Although of rare occurrence, recognition of adult-onset ABCC8-associated diabetes may help in targeting patients for SU therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc11-1469","type":"journal-article","created":{"date-parts":[[2011,12,31]],"date-time":"2011-12-31T01:31:46Z","timestamp":1325295106000},"page":"248-251","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":49,"title":["Clinical and Metabolic Features of Adult-Onset Diabetes Caused by <i>ABCC8<\/i> Mutations"],"prefix":"10.2337","volume":"35","author":[{"given":"Jean-Pierre","family":"Riveline","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France"},{"name":"Unit\u00e9 Mixte de Recherche S 872, Universit\u00e9 Pierre et Marie Curie-Paris 6, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Caen University Hospital, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Reznik","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Caen University Hospital, Caen, France"},{"name":"University of Caen Medical School, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Fetita","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, INSERM CIC9504, Saint-Louis Hospital, Paris-Diderot Paris-7 University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Philippe","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 8199, Centre National de la Recherche Scientifique, Lille Pasteur Institute, Lille, France"},{"name":"Lille Nord de France University, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Dechaume","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 8199, Centre National de la Recherche Scientifique, Lille Pasteur Institute, Lille, France"},{"name":"Lille Nord de France University, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Hartemann","sequence":"additional","affiliation":[{"name":"Service de Diab\u00e9tologie, APHP and Universit\u00e9 Paris VI, GH Piti\u00e9-Salp\u00eatri\u00e8re, Paris, 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