{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:03:19Z","timestamp":1790193799979,"version":"4.1.0"},"reference-count":28,"publisher":"American Diabetes Association","issue":"5","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":3430,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n                  <jats:sec>\n                     <jats:title>OBJECTIVE<\/jats:title>\n                     <jats:p>In patients with type 2 diabetes, but not type 1 diabetes, abnormal secretion of incretins in response to oral nutrients has been described. In healthy youths, we recently reported accentuated glucagon-like peptide 1 (GLP-1) secretion in response to a diet soda sweetened with sucralose and acesulfame-K. In this study, we examined the effect of diet soda on gut hormones in youths with diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                     <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                     <jats:p>Subjects aged 12\u201325 years with type 1 diabetes (n = 9) or type 2 diabetes (n = 10), or healthy control participants (n = 25) drank 240 mL cola-flavored caffeine-free diet soda or carbonated water, followed by a 75-g glucose load, in a randomized, cross-over design. Glucose, C-peptide, GLP-1, glucose-dependent insulinotropic peptide (GIP), and peptide Tyr-Tyr (PYY) were measured for 180 min. Glucose and GLP-1 have previously been reported for the healthy control subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                     <jats:title>RESULTS<\/jats:title>\n                     <jats:p>GLP-1 area under the curve (AUC) was 43% higher after ingestion of diet soda versus carbonated water in individuals with type 1 diabetes (P = 0.020), similar to control subjects (34% higher, P = 0.029), but was unaffected by diet soda in patients with type 2 diabetes (P = 0.92). Glucose, C-peptide, GIP, and PYY AUC were not statistically different between the two conditions in any group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                     <jats:title>CONCLUSIONS<\/jats:title>\n                     <jats:p>Ingestion of diet soda before a glucose load augmented GLP-1 secretion in type 1 diabetic and control subjects but not type 2 diabetic subjects. GIP and PYY secretion were not affected by diet soda. The clinical significance of this increased GLP-1 secretion, and its absence in youths with type 2 diabetes, needs to be determined.<\/jats:p>\n                  <\/jats:sec>\n               <\/jats:sec>","DOI":"10.2337\/dc11-2424","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T04:35:33Z","timestamp":1331613333000},"page":"959-964","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":95,"title":["Effects of Diet Soda on Gut Hormones in Youths With Diabetes"],"prefix":"10.2337","volume":"35","author":[{"given":"Rebecca J.","family":"Brown","sequence":"first","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Walter","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, 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