{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:08:38Z","timestamp":1790863718194,"version":"4.1.0"},"reference-count":14,"publisher":"American Diabetes Association","issue":"11","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":3241,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To examine whether baseline pulse pressure (PP), a marker of arterial stiffness, is associated with subsequent development of atrial fibrillation (AF) in type 2 diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>A total of 350 type 2 diabetic patients, who were free from AF at baseline, were followed for 10 years. A standard electrocardiogram was performed annually and a diagnosis of incident AF was confirmed in affected participants by a single cardiologist.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>During the follow-up, 32 patients (9.1% of total) developed incident AF. After adjustments for age, sex, BMI, diabetes duration, presence of left ventricular hypertrophy, hypertension treatment, kidney dysfunction, and pre-existing history of coronary heart disease, heart failure, and mild valvular disease, baseline PP was associated with an increased incidence of AF (adjusted odds ratio 1.76 for each SD increment [95% CI 1.1\u20132.8]; P &amp;lt; 0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Our findings suggest that increased PP independently predicts incident AF in patients with type 2 diabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc12-0314","type":"journal-article","created":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T07:31:37Z","timestamp":1343374297000},"page":"2337-2339","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":20,"title":["Increased Pulse Pressure Independently Predicts Incident Atrial Fibrillation in Patients With Type 2 Diabetes"],"prefix":"10.2337","volume":"35","author":[{"given":"Filippo","family":"Valbusa","sequence":"first","affiliation":[{"name":"Division of Internal Medicine, \u201cSacro Cuore\u201d Hospital of Negrar, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bonapace","sequence":"additional","affiliation":[{"name":"Division of Cardiology, \u201cSacro Cuore\u201d Hospital of Negrar, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Diabetes Unit, \u201cSacro Cuore\u201d Hospital of Negrar, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Zenari","sequence":"additional","affiliation":[{"name":"Diabetes Unit, \u201cSacro Cuore\u201d Hospital of Negrar, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Arcaro","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, \u201cSacro Cuore\u201d Hospital of Negrar, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Targher","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2012,10,13]]},"reference":[{"key":"2022031221224378000_B1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0140-6736(11)61514-6","article-title":"Atrial fibrillation","volume":"379","author":"Lip","year":"2012","journal-title":"Lancet"},{"key":"2022031221224378000_B2","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/01.CIR.98.10.946","article-title":"Impact of atrial fibrillation on the risk of death: the Framingham Heart Study","volume":"98","author":"Benjamin","year":"1998","journal-title":"Circulation"},{"key":"2022031221224378000_B3","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1161\/CIRCULATIONAHA.110.986661","article-title":"Mortality associated with atrial fibrillation in patients with myocardial infarction: a systematic review and meta-analysis","volume":"123","author":"Jabre","year":"2011","journal-title":"Circulation"},{"key":"2022031221224378000_B4","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1001\/jama.297.7.709","article-title":"Pulse pressure and risk of new-onset atrial fibrillation","volume":"297","author":"Mitchell","year":"2007","journal-title":"JAMA"},{"key":"2022031221224378000_B5","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jelectrocard.2008.02.013","article-title":"Validity of electrocardiographic classification of left ventricular hypertrophy across adult ethnic groups with echocardiography as a standard","volume":"41","author":"Vanezis","year":"2008","journal-title":"J Electrocardiol"},{"key":"2022031221224378000_B6","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1161\/01.HYP.0000128420.01881.aa","article-title":"Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study","volume":"43","author":"Mitchell","year":"2004","journal-title":"Hypertension"},{"key":"2022031221224378000_B7","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.amjhyper.2006.05.001","article-title":"Electrocardiographic left ventricular hypertrophy and arterial stiffness: the Ohasama study","volume":"19","author":"Watabe","year":"2006","journal-title":"Am J Hypertens"},{"key":"2022031221224378000_B8","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.amjcard.2006.06.035","article-title":"Relation of arterial stiffness to left ventricular diastolic function and cardiovascular risk prediction in patients &gt; 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