{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:14:08Z","timestamp":1791155648465,"version":"4.1.0"},"reference-count":33,"publisher":"American Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":3186,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Ketosis-prone atypical diabetes (KPD) is a subtype of diabetes in which the pathophysiology is yet to be unraveled. The aim of this study was to characterize \u03b2- and \u03b1-cell functions in Africans with KPD during remission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>We characterized \u03b2- and \u03b1-cell functions in Africans with KPD during remission. The cohort comprised 15 sub-Saharan Africans who had been insulin-free for a median of 6 months. Patients in remission were in good glycemic control (near-normoglycemic) and compared with 15 nondiabetic control subjects matched for age, sex, ethnicity, and BMI. Plasma insulin, C-peptide, and glucagon concentrations were measured in response to oral and intravenous glucose and to combined intravenous arginine and glucose. Early insulin secretion was measured during a 75-g oral glucose tolerance test. Insulin secretion rate and glucagon were assessed in response to intravenous glucose ramping.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Early insulin secretion and maximal insulin secretion rate were lower in patients compared with control participants. In response to combined arginine and glucose stimulation, maximal insulin response was reduced. Glucagon suppression was also decreased in response to oral and intravenous glucose but not in response to arginine and insulin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Patients with KPD in protracted near-normoglycemic remission have impaired insulin response to oral and intravenous glucose and to arginine, as well as impaired glucagon suppression. Our results suggest that \u03b2- and \u03b1-cell dysfunctions both contribute to the pathophysiology of KPD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc12-0798","type":"journal-article","created":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T00:19:52Z","timestamp":1346285992000},"page":"118-123","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":39,"title":["\u03b2- and \u03b1-Cell Dysfunctions in Africans With Ketosis-Prone Atypical Diabetes During Near-Normoglycemic Remission"],"prefix":"10.2337","volume":"36","author":[{"given":"Sim\u00e9on-Pierre","family":"Choukem","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, Saint-Louis University Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, University Paris-Diderot Paris-7, Paris, France"},{"name":"Clinical Investigation Center, INSERM-Centres d'investigation Clinique (CIC) 9504, Saint-Louis University Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, University Paris-Diderot Paris-7, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Sobngwi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Saint-Louis University Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, University Paris-Diderot Paris-7, Paris, France"},{"name":"Clinical Investigation Center, INSERM-Centres d'investigation Clinique (CIC) 9504, Saint-Louis University Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, University Paris-Diderot Paris-7, Paris, France"},{"name":"Institute of Health and Society, Newcastle University, Newcastle upon Tyne, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Boudou","sequence":"additional","affiliation":[{"name":"Unit of Transfer in Molecular Oncology and Hormonology, Saint-Louis University Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila-Sabrina","family":"Fetita","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Saint-Louis University Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, University Paris-Diderot Paris-7, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Porcher","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Computing, Saint-Louis University Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, University Paris-Diderot Paris-7, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fidaa","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Unit of Transfer in Molecular Oncology and Hormonology, Saint-Louis University Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Blondeau","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 Mixte de Recherche en Sant\u00e9 (UMRS) 872, Cordeliers Research Center, University Pierre et Marie Curie Paris-6, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Vexiau","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Saint-Louis University Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, University Paris-Diderot Paris-7, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Mauvais-Jarvis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Calvo","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center, INSERM-Centres d'investigation Clinique (CIC) 9504, Saint-Louis University Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, University Paris-Diderot Paris-7, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Gautier","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Saint-Louis University Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, University Paris-Diderot Paris-7, Paris, France"},{"name":"Clinical Investigation Center, INSERM-Centres d'investigation Clinique (CIC) 9504, Saint-Louis University Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, University Paris-Diderot Paris-7, Paris, France"},{"name":"INSERM Unit\u00e9 Mixte de Recherche en Sant\u00e9 (UMRS) 872, Cordeliers 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