{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:43:19Z","timestamp":1784889799030,"version":"3.55.0"},"reference-count":14,"publisher":"American Diabetes Association","issue":"11","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":2878,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>This randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Patients (n = 10) with delayed gastric emptying consumed one serving per day of each pasta for 8 weeks, with a 4-week washout. Gastric emptying time (t1\/2) was measured using the [13C]octanoic acid breath test at baseline and after each period, and blood glucose and insulin concentrations were determined after oral glucose load.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Soy germ pasta significantly accelerated the t1\/2 in these patients (161.2 \u00b1 17.5 min at baseline vs. 112.6 \u00b1 11.2 min after treatment, P = 0.009). Such change differed significantly (P = 0.009) from that for conventional pasta (153.6 \u00b1 24.2 vs. 156.2 \u00b1 27.4 min), without affecting glucose or insulin concentrations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>These findings suggest that soy germ pasta may offer a simple dietary approach to managing diabetic gastropathy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc12-1615","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T03:18:14Z","timestamp":1373339894000},"page":"3495-3497","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":25,"title":["Novel Soy Germ Pasta Enriched in Isoflavones Ameliorates Gastroparesis in Type 2 Diabetes"],"prefix":"10.2337","volume":"36","author":[{"given":"Kenneth D.R.","family":"Setchell","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Nardi","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology and Hepatology, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier-Maria","family":"Battezzati","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Department of Health Sciences, San Paolo School of Medicine, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Asciutti","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology and Hepatology, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Castellani","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology and Hepatology, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Perriello","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Clerici","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology and Hepatology, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"2022031302183525600_B1"},{"key":"2022031302183525600_B2"},{"key":"2022031302183525600_B3","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1001\/jama.283.17.2228-JFD00003-2-1","article-title":"From the Food and Drug Administration: withdrawal of troglitazone and cisapride","volume":"283","author":"Henney","year":"2000","journal-title":"JAMA"},{"key":"2022031302183525600_B4"},{"key":"2022031302183525600_B5"},{"key":"2022031302183525600_B6","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1093\/jn\/137.10.2270","article-title":"Pasta naturally enriched with isoflavone aglycons from soy germ reduces serum lipids and improves markers of cardiovascular risk","volume":"137","author":"Clerici","year":"2007","journal-title":"J Nutr"},{"key":"2022031302183525600_B7"},{"key":"2022031302183525600_B8"},{"key":"2022031302183525600_B9"},{"key":"2022031302183525600_B10"},{"key":"2022031302183525600_B11"},{"key":"2022031302183525600_B12"},{"key":"2022031302183525600_B13"},{"key":"2022031302183525600_B14"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/36\/11\/3495\/616322\/3495.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/36\/11\/3495\/616322\/3495.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T06:28:42Z","timestamp":1647152922000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/36\/11\/3495\/38115\/Novel-Soy-Germ-Pasta-Enriched-in-Isoflavones"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,15]]},"references-count":14,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,10,15]]},"published-print":{"date-parts":[[2013,11,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc12-1615","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,15]]}}}