{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:59:10Z","timestamp":1790675950172,"version":"4.1.0"},"reference-count":36,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":3027,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>In adults, 1-h glucose during an oral glucose tolerance test (OGTT) predicts the development of type 2 diabetes independent of fasting and 2-h glucose concentrations. The purpose of the current investigation was to examine the utility of elevated 1-h glucose levels to prospectively predict deterioration in \u03b2-cell function and the development of prediabetes in high-risk youth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Obese Latino youth with a family history of type 2 diabetes (133 male and 100 female; age 11.1 \u00b1 1.7 years) completed a baseline OGTT and were divided into two groups based upon a 1-h glucose threshold of 155 mg\/dL (&amp;lt;155 mg\/dL, n = 151, or \u2265155 mg\/dL, n = 82). Youth were followed annually for up to 8 years for assessment of glucose tolerance, body composition by dual-energy X-ray absorptiometry, and insulin sensitivity, insulin secretion, and the disposition index by the frequently sampled intravenous glucose tolerance test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Over time, the \u2265155 mg\/dL group exhibited a significantly greater decline in \u03b2-cell function compared with youth with a 1-h glucose &amp;lt;155 mg\/dL (\u03b2 = \u2212327.8 \u00b1 126.2, P = 0.01). Moreover, this decline was independent of fasting or 2-h glucose and body composition. When the data were restricted to only participants with normal glucose tolerance at baseline, a 1-h glucose \u2265155 mg\/dL was independently associated with a 2.5 times greater likelihood of developing prediabetes during follow-up (95% CI 1.6\u20134.1, P = 0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>These data suggest that a 1-h glucose \u2265155 mg\/dL during an OGTT is an independent predictor of \u03b2-cell deterioration and progression to prediabetes among obese Latino youth.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc12-1861","type":"journal-article","created":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T06:48:56Z","timestamp":1357973336000},"page":"1681-1686","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":38,"title":["One-Hour Glucose During an Oral Glucose Challenge Prospectively Predicts \u03b2-Cell Deterioration and Prediabetes in Obese Hispanic Youth"],"prefix":"10.2337","volume":"36","author":[{"given":"Joon Young","family":"Kim","sequence":"first","affiliation":[{"name":"Kinesiology Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Goran","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California"},{"name":"Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia M.","family":"Toledo-Corral","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J.","family":"Weigensberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myunghan","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Nursing and Health Innovation, Arizona State University, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Q.","family":"Shaibi","sequence":"additional","affiliation":[{"name":"Kinesiology Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, Arizona"},{"name":"College of Nursing and Health Innovation, Arizona State University, Phoenix, Arizona"},{"name":"Division of Endocrinology and Diabetes, Phoenix Children\u2019s Hospital, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"2022031222390309300_B1","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1001\/jama.288.14.1728","article-title":"Prevalence and trends in overweight among US children and adolescents, 1999-2000","volume":"288","author":"Ogden","year":"2002","journal-title":"JAMA"},{"key":"2022031222390309300_B2","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1001\/jama.297.24.2716","article-title":"Incidence of diabetes in youth in the United States","volume":"297","author":"The Writing Group for the SEARCH for Diabetes in Youth Study Group","year":"2007","journal-title":"JAMA"},{"key":"2022031222390309300_B3","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.2337\/dc09-S204","article-title":"Diabetes in Hispanic American youth: prevalence, incidence, demographics, and clinical characteristics: the SEARCH for Diabetes in Youth Study","volume":"32","author":"Lawrence","year":"2009","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B4","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1056\/NEJMoa012578","article-title":"Prevalence of impaired glucose tolerance among children and adolescents with marked obesity","volume":"346","author":"Sinha","year":"2002","journal-title":"N Engl J Med"},{"key":"2022031222390309300_B5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1210\/jc.2003-031402","article-title":"Impaired glucose tolerance and reduced beta-cell function in overweight Latino children with a positive family history for type 2 diabetes","volume":"89","author":"Goran","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031222390309300_B6","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.2337\/diabetes.50.11.2444","article-title":"Longitudinal study on pubertal insulin resistance","volume":"50","author":"Goran","year":"2001","journal-title":"Diabetes"},{"key":"2022031222390309300_B7","doi-asserted-by":"crossref","first-page":"638","DOI":"10.2337\/diacare.28.3.638","article-title":"Youth type 2 diabetes: insulin resistance, beta-cell failure, or both?","volume":"28","author":"Gungor","year":"2005","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B8","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2337\/diacare.20.7.1183","article-title":"Report of the expert committee on the diagnosis and classification of diabetes Mellitus","volume":"20","year":"1997","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B9","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1046\/j.1464-5491.2002.00835.x","article-title":"Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention","volume":"19","author":"Unwin","year":"2002","journal-title":"Diabet Med"},{"key":"2022031222390309300_B10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.diabres.2007.05.004","article-title":"Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic overview and meta-analysis of prospective studies","volume":"78","author":"Gerstein","year":"2007","journal-title":"Diabetes Res Clin Pract"},{"key":"2022031222390309300_B11","doi-asserted-by":"crossref","first-page":"902","DOI":"10.2337\/diacare.28.4.902","article-title":"Predictors of changes in glucose tolerance status in obese youth","volume":"28","author":"Weiss","year":"2005","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B12","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.2337\/db08-0445","article-title":"Persistence of pre-diabetes in overweight and obese Hispanic children: association with progressive insulin resistance, poor beta-cell function, and increasing visceral fat","volume":"57","author":"Goran","year":"2008","journal-title":"Diabetes"},{"key":"2022031222390309300_B13","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.2337\/dc06-1331","article-title":"What is the best predictor of future type 2 diabetes?","volume":"30","author":"Abdul-Ghani","year":"2007","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B14","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.2337\/dc08-0225","article-title":"One-hour plasma glucose concentration and the metabolic syndrome identify subjects at high risk for future type 2 diabetes","volume":"31","author":"Abdul-Ghani","year":"2008","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2337\/dc08-1264","article-title":"Fasting versus postload plasma glucose concentration and the risk for future type 2 diabetes: results from the Botnia Study","volume":"32","author":"Abdul-Ghani","year":"2009","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B16","first-page":"572","article-title":"One-hour plasma glucose concentration during the OGTT: what does it tell about \u03b2-cell function relative to insulin sensitivity in overweight\/obese children?","volume":"12","author":"Tfayli","year":"2011","journal-title":"Pediatr Diabetes"},{"key":"2022031222390309300_B17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variations in pattern of pubertal changes in girls","volume":"44","author":"Marshall","year":"1969","journal-title":"Arch Dis Child"},{"key":"2022031222390309300_B18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/adc.45.239.13","article-title":"Variations in the pattern of pubertal changes in boys","volume":"45","author":"Marshall","year":"1970","journal-title":"Arch Dis Child"},{"key":"2022031222390309300_B19","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1172\/JCI110398","article-title":"Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose","volume":"68","author":"Bergman","year":"1981","journal-title":"J Clin Invest"},{"key":"2022031222390309300_B20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3102\/10769986023004323","article-title":"Using SAS PROC MIXED to fit multilevel models, hierarchical models, and individual growth models","volume":"23","author":"Singer","year":"1998","journal-title":"J Educ Behav Stat"},{"key":"2022031222390309300_B21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/0163278709338554","article-title":"Analyzing longitudinal data with the linear mixed models procedure in SPSS","volume":"32","author":"West","year":"2009","journal-title":"Eval Health Prof"},{"key":"2022031222390309300_B22","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.2307\/2531734","article-title":"Models for longitudinal data: a generalized estimating equation approach","volume":"44","author":"Zeger","year":"1988","journal-title":"Biometrics"},{"key":"2022031222390309300_B23","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.2337\/dc09-2261","article-title":"One-hour plasma glucose identifies insulin resistance and beta-cell dysfunction in individuals with normal glucose tolerance: cross-sectional data from the Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study","volume":"33","author":"Manco","year":"2010","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00592-012-0384-3","article-title":"1-Hour plasma glucose in obese youth","volume":"49","author":"Manco","year":"2012","journal-title":"Acta Diabetol"},{"key":"2022031222390309300_B25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1067\/mpd.2001.109603","article-title":"Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome","volume":"138","author":"Lewy","year":"2001","journal-title":"J Pediatr"},{"key":"2022031222390309300_B26","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.2337\/diacare.25.12.2184","article-title":"Insulin resistance and associated compensatory responses in african-american and Hispanic children","volume":"25","author":"Goran","year":"2002","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B27","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI7231","article-title":"The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus","volume":"104","author":"Weyer","year":"1999","journal-title":"J Clin Invest"},{"key":"2022031222390309300_B28","doi-asserted-by":"crossref","first-page":"S212","DOI":"10.2337\/diabetes.51.2007.S212","article-title":"Accurate assessment of beta-cell function: the hyperbolic correction","volume":"51","author":"Bergman","year":"2002","journal-title":"Diabetes"},{"key":"2022031222390309300_B29","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1399-5448.2009.00601.x","article-title":"Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes","volume":"11","author":"Elder","year":"2010","journal-title":"Pediatr Diabetes"},{"key":"2022031222390309300_B30","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.2337\/diacare.28.10.2519","article-title":"Decreased beta-cell function in overweight Latino children with impaired fasting glucose","volume":"28","author":"Weigensberg","year":"2005","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B31","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.2337\/dc09-2292","article-title":"Declining beta-cell function relative to insulin sensitivity with increasing fasting glucose levels in the nondiabetic range in children","volume":"33","author":"Tfayli","year":"2010","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B32","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.2337\/dc11-0423","article-title":"Declining \u03b2-cell function relative to insulin sensitivity with escalating OGTT 2-h glucose concentrations in the nondiabetic through the diabetic range in overweight youth","volume":"34","author":"Burns","year":"2011","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.2337\/db11-1111","article-title":"Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths: a longitudinal study","volume":"61","author":"Giannini","year":"2012","journal-title":"Diabetes"},{"key":"2022031222390309300_B34","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.2337\/db05-1200","article-title":"Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study","volume":"55","author":"Abdul-Ghani","year":"2006","journal-title":"Diabetes"},{"key":"2022031222390309300_B35","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.2337\/dc10-0004","article-title":"From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation","volume":"33","author":"Bacha","year":"2010","journal-title":"Diabetes Care"},{"key":"2022031222390309300_B36","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1210\/jc.2008-0801","article-title":"Reproducibility of the oral glucose tolerance test in overweight children","volume":"93","author":"Libman","year":"2008","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/36\/6\/1681\/614707\/1681.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/36\/6\/1681\/614707\/1681.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:54:40Z","timestamp":1647132880000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/36\/6\/1681\/33102\/One-Hour-Glucose-During-an-Oral-Glucose-Challenge"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,15]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,5,15]]},"published-print":{"date-parts":[[2013,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc12-1861","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,15]]}}}