{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:42:40Z","timestamp":1782456160322,"version":"3.54.5"},"reference-count":40,"publisher":"American Diabetes Association","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":2941,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>We determined prevalence, risk factors, phenotype, and pathophysiological mechanism of new-onset diabetes after transplantation (NODAT) to generate strategies for optimal pharmacological management of hyperglycemia in NODAT patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Retrospective cohort study comparing demographics, laboratory data, and oral glucose tolerance test (OGTT)-derived metabolic parameters from kidney transplant recipients versus subjects not receiving transplants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Among 1,064 stable kidney transplant recipients (\u22656 months posttransplantation), 113 (11%) had a history of NODAT and 132 (12%) had pretransplant diabetes. In the remaining patients, randomly assigned OGTTs showed a high prevalence of abnormal glucose metabolism (11% diabetes; 32% impaired fasting glucose, impaired glucose tolerance, or both), predominantly in older patients who received tacrolimus as the primary immunosuppressant. Compared with 1,357 nontransplant subjects, stable kidney transplant recipients had lower basal glucose, higher glycated hemoglobin, lower insulin secretion, and greater insulin sensitivity in each of the three subgroups, defined by OGTT 2-h glucose (&amp;lt;140, 140\u2013199, \u2265200 mg\/dL). These findings were reinforced in linear spline interpolation models of insulin secretion and sensitivity (all P &amp;lt; 0.001) and in another regression model in which the estimated oral glucose insulin sensitivity index was substantially higher (by 79\u2013112 mL\/min m2) for transplant versus nontransplant subjects despite adjustments for age, sex, and BMI (all P &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Glucose metabolism differs substantially between kidney transplant recipients and nontransplant controls. Because impaired insulin secretion appears to be the predominant pathophysiological feature after renal transplantation, early therapeutic interventions that preserve, maintain, or improve \u03b2-cell function are potentially beneficial in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc12-2441","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T03:55:39Z","timestamp":1368071739000},"page":"2763-2771","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":109,"title":["Glucose Metabolism After Renal Transplantation"],"prefix":"10.2337","volume":"36","author":[{"given":"Manfred","family":"Hecking","sequence":"first","affiliation":[{"name":"Department of Nephrology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kainz","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Werzowa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Haidinger","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"D\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tura","sequence":"additional","affiliation":[{"name":"Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Karaboyas","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter H.","family":"H\u00f6rl","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wolzt","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Sharif","sequence":"additional","affiliation":[{"name":"Renal Institute of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roden","sequence":"additional","affiliation":[{"name":"Department of Metabolic Diseases, University Clinics D\u00fcsseldorf, Institute for Clinical Diabetology, German Diabetes Center, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermanno","family":"Moro","sequence":"additional","affiliation":[{"name":"Venice Regional General Hospital, Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pacini","sequence":"additional","affiliation":[{"name":"Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich K.","family":"Port","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus D.","family":"S\u00e4emann","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2013,8,13]]},"reference":[{"key":"2022031302040554300_B1","unstructured":"Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients. 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