{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:03:10Z","timestamp":1776261790729,"version":"3.50.1"},"reference-count":40,"publisher":"American Diabetes Association","issue":"12","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":2845,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To investigate the effect of biliopancreatic diversion (BPD) surgery on \u03b2-cell function in grade I and II obese patients with type 2 diabetes using oral and intravenous glucose loads.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Sixty-eight women were divided into the following three groups: 19 lean-control (23.0 \u00b1 2.2 kg\/m2) and 18 obese-control (35.0 \u00b1 4.8 kg\/m2) subjects with normal glucose tolerance, and 31 obese patients with type 2 diabetes (36.3 \u00b1 3.7 kg\/m2). Of the 31 diabetic women, 64% underwent BPD (n = 20, BMI: 36.5 \u00b1 3.7 kg\/m2) and were reassessed 1 month after surgery. Oral glucose tolerance tests and hyperglycemic clamps were performed. Mathematical modeling was used to analyze basal and stimulated \u03b2-cell function, insulin sensitivity (IS), hepatic extraction (HE) of insulin, and delay time of \u03b2-cell response to a specific plasma glucose concentration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>After BPD, restoration of the basal disposition index (P &amp;lt; 0.001) and improvement of the stimulated disposition indices in oral and intravenous glucose stimulation of the \u03b2-cell were observed (P &amp;lt; 0.05). In both dynamic tests, there were no changes in the delay time of \u03b2-cell response. IS for oral glucose stimulation (ISoral) and intravenous clamp glucose stimulation (ISclamp) was completely normalized (P &amp;lt; 0.001). ISoral and ISclamp increased approximately 5.0-fold and 3.5-fold, respectively (P &amp;lt; 0.01). The HE of insulin increased in the basal (P &amp;lt; 0.05) and stimulated states (P &amp;lt; 0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>\u03b2-Cell function, IS, and HE of insulin improved after BPD, which improved glycemic control.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc13-0530","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T03:52:38Z","timestamp":1382068358000},"page":"4117-4124","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":10,"title":["\u03b2-Cell Function Improvements in Grade I\/II Obese Subjects With Type 2 Diabetes 1 Month After Biliopancreatic Diversion"],"prefix":"10.2337","volume":"36","author":[{"given":"Ana Carolina","family":"Junqueira Vasques","sequence":"first","affiliation":[{"name":"Laboratory of Investigation on Metabolism and Diabetes, Gastrocentro, State University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Carlos","family":"Pareja","sequence":"additional","affiliation":[{"name":"Laboratory of Investigation on Metabolism and Diabetes, Gastrocentro, State University of Campinas, S\u00e3o Paulo, Brazil"},{"name":"Department of Surgery, Diabetic Surgery Unit, State University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria da Saude","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Investigation on Metabolism and Diabetes, Gastrocentro, State University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Satake Novaes","sequence":"additional","affiliation":[{"name":"Laboratory of Investigation on Metabolism and Diabetes, Gastrocentro, State University of Campinas, S\u00e3o Paulo, 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