{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:37:15Z","timestamp":1790213835053,"version":"4.1.0"},"reference-count":33,"publisher":"American Diabetes Association","issue":"11","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":2878,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>We studied whether patterns of glucose absorption during oral glucose tolerance tests (OGTTs) were abnormal in individuals with impaired glucose regulation and whether they were related to sex and body size (height and fat-free mass). We also examined how well differences in insulin sensitivity and \u03b2-cell function measured by gold-standard tests were reflected in the corresponding OGTT-derived estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESEARCH DESIGN AND METHODS<\/jats:title><jats:p>With validated methods, various aspects of glucose absorption were estimated from 12-point, 3-h, 75-g OGTTs in 66 individuals with normal glucose tolerance (NGT), isolated impaired fasting glucose (i-IFG), or isolated impaired glucose tolerance (i-IGT). Insulin sensitivity and \u03b2-cell function were measured with the euglycemic-hyperinsulinemic clamp and intravenous glucose tolerance tests, respectively. Surrogate markers of both conditions were calculated from OGTTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>More rapid glucose absorption (P \u2264 0.036) and reduced late glucose absorption (P \u2264 0.039) were observed in the i-IFG group relative to NGT and i-IGT groups. Women with i-IGT had a lower early glucose absorption than did men with i-IGT (P = 0.041); however, this difference did not persist when differences in body size were taken into account (P &amp;gt; 0.28). Faster glucose absorption was related to higher fasting (P = 0.001) and lower 2-h (P = 0.001) glucose levels and to greater height and fat-free mass (P &amp;lt; 0.001). All OGTT-derived measures of insulin sensitivity, but only one of three measures of \u03b2-cell function, reflected the differences for these parameters between those with normal and impaired glucose regulation as measured by gold-standard tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Glucose absorption patterns during an OGTT are significantly related to plasma glucose levels and body size, which should be taken into account when estimating \u03b2-cell function from OGTTs in epidemiological studies.<\/jats:p><\/jats:sec>","DOI":"10.2337\/dc13-0592","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T05:24:42Z","timestamp":1380000282000},"page":"3691-3697","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":42,"title":["Impact of Glucose Tolerance Status, Sex, and Body Size on Glucose Absorption Patterns During OGTTs"],"prefix":"10.2337","volume":"36","author":[{"given":"Kristine","family":"F\u00e6rch","sequence":"first","affiliation":[{"name":"Steno Diabetes Center A\/S, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pacini","sequence":"additional","affiliation":[{"name":"Metabolic Unit, Institute of Biomedical Engineering (ISIB-CNR), Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center A\/S, Gentofte, Denmark"},{"name":"The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Hansen","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"},{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tura","sequence":"additional","affiliation":[{"name":"Metabolic Unit, Institute of Biomedical Engineering (ISIB-CNR), Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte","family":"Vistisen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center A\/S, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"2022031302034252600_B1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.2337\/dc08-1869","article-title":"Progression to impaired glucose regulation and diabetes in the population-based Inter99 study","volume":"32","author":"Engberg","year":"2009","journal-title":"Diabetes Care"},{"key":"2022031302034252600_B2","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/S0140-6736(12)60283-9","article-title":"Prediabetes: a high-risk state for diabetes development","volume":"379","author":"Tab\u00e1k","year":"2012","journal-title":"Lancet"},{"key":"2022031302034252600_B3","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1007\/s00125-010-1673-4","article-title":"Sex differences in glucose levels: a consequence of physiology or methodological convenience? 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