{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:57:12Z","timestamp":1789016232508,"version":"build-2803163510"},"reference-count":31,"publisher":"American Diabetes Association","issue":"3","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":2755,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To evaluate the presence of early carotid and coronary atherosclerosis in asymptomatic patients with type 1 diabetes with no history of ischemic heart disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>One hundred and fifty patients with type 1 diabetes (58% males; 38.6 \u00b1 8.1 years, 20.4 \u00b1 8.1 years of evolution; HbA1c 8.1 \u00b1 2.3%; 52% nonsmokers; 26% retinopathy; 9% microalbuminuria) and 50 nondiabetic control subjects age and sex matched were studied. Carotid ultrasonography to determine common carotid artery intima-media thickness (c-IMT) and the presence of atheroma plaques and cardiac computed tomography for calcium analysis and quantification (coronary artery calcium score [CACS]) were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Most patients with type 1 diabetes and control subjects displayed a CACS of 0 (82 vs. 92%). Patients with type 1 diabetes with CACS \u22651 were older and had higher HbA1c (44.5 \u00b1 5.1 vs. 36.7 \u00b1 8.1 years [P &amp;lt; 0.001] and 8.5 \u00b1 1.1 vs. 7.8 \u00b1 1.0% [P &amp;lt; 0.003], respectively) and longer evolution of diabetes (25.4 \u00b1 9.2 vs. 19.3 \u00b1 7.4 years, P &amp;lt; 0.005) and mean c-IMT (0.67 \u00b1 0.18 vs. 0.53 \u00b1 0.11 mm, P &amp;lt; 0.001) compared with patients with CACS of 0. Smoking (P &amp;lt; 0.02), nephropathy (P &amp;lt; 0.05), retinopathy (P &amp;lt; 0.05), and male sex (P &amp;lt; 0.03) were significantly and positively associated with CACS \u22651. Mean c-IMT was significantly higher in patients with type 1 diabetes (0.55 \u00b1 0.14 vs. 0.48 \u00b1 0.14 mm, P &amp;lt; 0.01), and 11% of them presented atheroma plaques (8% of control subjects). Multivariant logistic regression analysis showed that c-IMT was related to CACS (\u03b2 = 6.87, P &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>A small percentage of patients with type 1 diabetes showed data suggestive of subclinical atherosclerosis. Universal screening of coronary disease in this population is not justified. Carotid ultrasonography may be useful for screening in the subset of patients with cardiovascular risk factors and long disease evolution.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc13-1453","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T03:52:38Z","timestamp":1382068358000},"page":"814-820","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":14,"title":["Low Prevalence of Subclinical Atherosclerosis in Asymptomatic Patients With Type 1 Diabetes in a European Mediterranean Population"],"prefix":"10.2337","volume":"37","author":[{"given":"Eva","family":"Aguilera","sequence":"first","affiliation":[{"name":"Endocrinology and Nutrition Unit, Department of Medicine, Institute of Research and Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enric","family":"Serra-Planas","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Department of Medicine, Institute of Research and Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Luisa","family":"Granada","sequence":"additional","affiliation":[{"name":"Biochemical Unit, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Alonso","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Department of Medicine, Institute of Research and Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pellitero","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Department of Medicine, Institute of Research and Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduarda","family":"Pizarro","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Hospital de Matar\u00f3, Matar\u00f3, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi Llu\u00eds","family":"Reverter","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Department of Medicine, Institute of Research and Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Salinas","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Department of Medicine, Institute of Research and Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta","family":"Soldevila","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Department of Medicine, Institute of Research and Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00eddac","family":"Mauricio","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Department of Medicine, Institute of Research and Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Puig-Domingo","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Department of Medicine, Institute of Research and Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2014,2,11]]},"reference":[{"key":"2022031220273257800_B1","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1007\/PL00002934","article-title":"Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes","volume":"44","author":"Morrish","year":"2001","journal-title":"Diabetologia"},{"key":"2022031220273257800_B2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1056\/NEJMoa021778","article-title":"Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes","volume":"348","author":"Gaede","year":"2003","journal-title":"N Engl J Med"},{"key":"2022031220273257800_B3","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s00125-003-1116-6","article-title":"Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes","volume":"46","author":"Laing","year":"2003","journal-title":"Diabetologia"},{"key":"2022031220273257800_B4","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1161\/01.CIR.0000124725.46165.2C","article-title":"Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes","volume":"109","author":"J\u00e4rvisalo","year":"2004","journal-title":"Circulation"},{"key":"2022031220273257800_B5","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0735-1097(02)02894-2","article-title":"Vascular function and carotid intimal-medial thickness in children with insulin-dependent diabetes mellitus","volume":"41","author":"Singh","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2022031220273257800_B6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2337\/diab.33.3.271","article-title":"The Pittsburgh insulin-dependent diabetes mellitus (IDDM) morbidity and mortality study. 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