{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:50:15Z","timestamp":1790175015509,"version":"4.1.0"},"reference-count":37,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":2667,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To test whether a weight loss program promotes greater weight loss, glycemic control, and improved cardiovascular disease risk factors compared with control conditions and whether there is a differential response to higher versus lower carbohydrate intake.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>This randomized controlled trial at two university medical centers enrolled 227 overweight or obese adults with type 2 diabetes and assigned them to parallel in-person diet and exercise counseling, with prepackaged foods in a planned menu during the initial phase, or to usual care (UC; two weight loss counseling sessions and monthly contacts).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Relative weight loss was 7.4% (95% CI 5.7\u20139.2%), 9.0% (7.1\u201310.9%), and 2.5% (1.3\u20133.8%) for the lower fat, lower carbohydrate, and UC groups (P &amp;lt; 0.001 intervention effect). Glycemic control markers and triglyceride levels were lower in the intervention groups compared with UC group at 1 year (fasting glucose 141 [95% CI 133\u2013149] vs. 159 [144\u2013174] mg\/dL, P = 0.023; hemoglobin A1c 6.9% [6.6\u20137.1%] vs. 7.5% [7.1\u20137.9%] or 52 [49\u201354] vs. 58 [54\u201363] mmol\/mol, P = 0.001; triglycerides 148 [134\u2013163] vs. 204 [173\u2013234] mg\/dL, P &amp;lt; 0.001). The lower versus higher carbohydrate groups maintained lower hemoglobin A1c (6.6% [95% CI 6.3\u20136.8%] vs. 7.2% [6.8\u20137.5%] or 49 [45\u201351] vs. 55 [51\u201358] mmol\/mol) at 1 year (P = 0.008).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The weight loss program resulted in greater weight loss and improved glycemic control in type 2 diabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc13-2900","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T08:26:50Z","timestamp":1398328010000},"page":"1573-1580","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":120,"title":["Weight Loss, Glycemic Control, and Cardiovascular Disease Risk Factors in Response to Differential Diet Composition in a Weight Loss Program in Type 2 Diabetes: A Randomized Controlled Trial"],"prefix":"10.2337","volume":"37","author":[{"given":"Cheryl L.","family":"Rock","sequence":"first","affiliation":[{"name":"Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley W.","family":"Flatt","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilge","family":"Pakiz","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela F.","family":"Leone","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerrin","family":"Brelje","sequence":"additional","affiliation":[{"name":"HealthPartners Research Institute for Education and Research and Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis D.","family":"Heath","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Quintana","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy E.","family":"Sherwood","sequence":"additional","affiliation":[{"name":"HealthPartners Research Institute for Education and Research and Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2014,5,10]]},"reference":[{"key":"2022031219405061100_B1","unstructured":"Ogden C, Carroll M, Kit B, Flegal K. 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