{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:29:02Z","timestamp":1790202542250,"version":"4.1.0"},"reference-count":50,"publisher":"American Diabetes Association","issue":"8","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>In observational studies, low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and other risk factors for cardiovascular disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>We present 1-year data from an ongoing 5-year trial in 511 individuals with impaired fasting glucose (IFG) and\/or impaired glucose tolerance (IGT) randomly assigned to 20,000 IU\/week vitamin D3 or placebo. An oral glucose tolerance test was performed at baseline and after 1 year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Mean baseline serum 25(OH)D was 59.9 nmol\/L and 61.1 nmol\/L in the vitamin D and placebo groups, respectively, and increased by 45.8 nmol\/L and 3.4 nmol\/L, respectively. With adjustment for baseline concentrations, no differences in measures of glucose metabolism, insulin secretion or sensitivity, blood pressure, or hs-CRP were found after 1 year. There was a slight, but significant decrease in total and LDL cholesterol in the vitamin D group compared with the placebo group, but as there was also a decrease in HDL cholesterol, the change in the total\/HDL cholesterol ratio did not differ significantly. Only analyzing subjects with 25(OH)D &amp;lt;50 nmol\/L did not change the results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>This study shows that vitamin D supplementation does not improve glycemic indices, blood pressure, or lipid status in subjects with IFG and\/or IGT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc14-0218","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T06:57:43Z","timestamp":1403247463000},"page":"2123-2131","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":101,"title":["No Effect of High-Dose Vitamin D Supplementation on Glycemic Status or Cardiovascular Risk Factors in Subjects With Prediabetes"],"prefix":"10.2337","volume":"37","author":[{"given":"Stina Therese","family":"Sollid","sequence":"first","affiliation":[{"name":"Troms\u00f8 Endocrine Research Group, The University of Troms\u00f8 - 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The Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnar M.","family":"Joakimsen","sequence":"additional","affiliation":[{"name":"Troms\u00f8 Endocrine Research Group, The University of Troms\u00f8 - The Arctic University of Norway, Troms\u00f8, Norway"},{"name":"Division of Internal Medicine, University Hospital of North Norway, Troms\u00f8, Norway"},{"name":"Department of Clinical Medicine, The University of Troms\u00f8 - The Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Schirmer","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, The University of Troms\u00f8 - The Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Nj\u00f8lstad","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, The University of Troms\u00f8 - 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