{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:15:25Z","timestamp":1790061325311,"version":"4.0.1"},"reference-count":32,"publisher":"American Diabetes Association","issue":"9","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>We studied the association between glycemic variability (GV) reflecting hypoglycemic stress and cardiovascular autonomic function in subjects with type 1 diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Forty-four type 1 diabetic patients (mean age 34 \u00b1 13 years, 40% male, 86% Caucasian, mean diabetes duration 13 \u00b1 6 years, mean hemoglobin A1c [HbA1c] 8.0 \u00b1 1.2% [64 \u00b1 5 mmol\/mol]) without cardiovascular disease, dyslipidemia, or hypertension participated in this pilot study. Indices of GV reflective of hypoglycemic stress (low blood glucose index [LBGI] and area under the curve [AUC] for hypoglycemia) were computed using data obtained during 5-day continuous glucose monitoring. Cardiovascular autonomic neuropathy (CAN) was assessed using standardized cardiovascular reflex testing and measures of heart rate variability (HRV), which were analyzed as time and frequency domain measures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Both LBGI and AUC hypoglycemia had a significant negative association with the low-frequency power of HRV (r = \u22120.47, P = 0.002; r = \u22120.43, P = 0.005, respectively) and with the high-frequency power of HRV (r = \u22120.37, P = 0.018; r = \u22120.38, P = 0.015, respectively). These inverse associations persisted after adjusting for HbA1c, although they were attenuated in multivariable analysis after adjustment for age, diabetes duration, and several other covariates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Increased GV promoting hypoglycemic stress was associated with reduced HRV independent of glycemic control as assessed by HbA1c. These pilot data suggest that glucose variability may contribute to cardiovascular autonomic dysfunction among adults with type 1 diabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc14-0445","type":"journal-article","created":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T04:12:39Z","timestamp":1403928759000},"page":"2616-2621","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":62,"title":["Association Between Impaired Cardiovascular Autonomic Function and Hypoglycemia in Patients With Type 1 Diabetes"],"prefix":"10.2337","volume":"37","author":[{"given":"Mamta","family":"Jaiswal","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"McKeon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Boston University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Comment","sequence":"additional","affiliation":[{"name":"Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Henderson","sequence":"additional","affiliation":[{"name":"Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Plunkett","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Nelson","sequence":"additional","affiliation":[{"name":"Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodica","family":"Pop-Busui","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"2022051617102733700_B1","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.2337\/diacare.26.6.1895","article-title":"The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis","volume":"26","author":"Maser","year":"2003","journal-title":"Diabetes Care"},{"key":"2022051617102733700_B2","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.2337\/dc10-0125","article-title":"Effects of cardiac autonomic dysfunction on mortality risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial","volume":"33","author":"Pop-Busui","year":"2010","journal-title":"Diabetes Care"},{"key":"2022051617102733700_B3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/dmrr.1239","article-title":"Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management","volume":"27","author":"Spallone","year":"2011","journal-title":"Diabetes Metab Res Rev"},{"key":"2022051617102733700_B4","first-page":"873","article-title":"American Academy of Neurology. 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