{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T22:37:38Z","timestamp":1722811058981},"reference-count":15,"publisher":"American Diabetes Association","issue":"9","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>We hypothesized the meaningful coexistence of neuropathic pain and nondipping in painful diabetic polyneuropathy (PDPN).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>In 113 patients with PDPN, with painless diabetic polyneuropathy (DPN+) and without DPN (DPN\u2212), neuropathic pain, sleep, risk for obstructive sleep apnea (OSA), autonomic function, and blood pressure (BP) circadian pattern were assessed using the Douleur Neuropathique en 4 Questions (DN4), the Medical Outcomes Study Sleep Scale, the Berlin Questionnaire, cardiovascular reflex tests, and ambulatory BP monitoring.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Patients with PDPN showed higher nighttime systolic BP (130.4 \u00b1 15.6 mmHg) than both DPN\u2212 (119.9 \u00b1 10.6 mmHg; P &amp;lt; 0.0001) and DPN+ patients (124.2 \u00b1 12.3 mmHg; P &amp;lt; 0.05), and lower day\u2013night difference (\u2206) in systolic BP (5.5 \u00b1 6.5 vs. 8.6 \u00b1 7.7%; P &amp;lt; 0.05) and diastolic BP than DPN\u2212 patients. In a stepwise regression analysis, orthostatic hypotension, high risk for OSA, and PDPN (DN4 interview) were independent determinants of \u2206 in systolic BP (r = 0.46; P = 0.0001), \u2206 in diastolic BP, and nighttime systolic BP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>PDPN is associated with higher nocturnal systolic BP and impaired BP circadian pattern independent of pain-related comorbidities, suggesting a condition of high cardiovascular risk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc14-0528","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T04:11:05Z","timestamp":1403842265000},"page":"2640-2642","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":7,"title":["A Novel Association Between Nondipping and Painful Diabetic Polyneuropathy"],"prefix":"10.2337","volume":"37","author":[{"given":"Cinzia","family":"D\u2019Amato","sequence":"first","affiliation":[{"name":"Endocrinology, Department of Systems Medicine, Tor Vergata University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Morganti","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Systems Medicine, Tor Vergata University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Di Gennaro","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Systems Medicine, Tor Vergata University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Greco","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Systems Medicine, Tor Vergata University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girolama A.","family":"Marfia","sequence":"additional","affiliation":[{"name":"Neurology, Department of Systems Medicine, Tor Vergata University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenza","family":"Spallone","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Systems Medicine, Tor Vergata University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"2022051610564509600_B1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jpainsymman.2005.04.009","article-title":"Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep","volume":"30","author":"Gore","year":"2005","journal-title":"J Pain Symptom Manage"},{"key":"2022051610564509600_B2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/dmrr.1239","article-title":"Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management","volume":"27","author":"Spallone","year":"2011","journal-title":"Diabetes Metab Res Rev"},{"key":"2022051610564509600_B3","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.5665\/sleep.1382","article-title":"Sleep duration and sleep quality in relation to 12-year cardiovascular disease incidence: the MORGEN study","volume":"34","author":"Hoevenaar-Blom","year":"2011","journal-title":"Sleep"},{"key":"2022051610564509600_B4","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/01.hjh.0000431740.32696.cc","article-title":"2013 ESH\/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"31","author":"Mancia","year":"2013","journal-title":"J Hypertens"},{"key":"2022051610564509600_B5","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2337\/diacare.17.11.1281","article-title":"A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy","volume":"17","author":"Feldman","year":"1994","journal-title":"Diabetes Care"},{"key":"2022051610564509600_B6","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2337\/dc10-1303","article-title":"Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments","volume":"33","author":"Tesfaye","year":"2010","journal-title":"Diabetes Care"},{"key":"2022051610564509600_B7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pain.2004.12.010","article-title":"Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)","volume":"114","author":"Bouhassira","year":"2005","journal-title":"Pain"},{"key":"2022051610564509600_B8","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1212\/01.wnl.0000282763.29778.59","article-title":"Neuropathic pain: redefinition and a grading system for clinical and research purposes","volume":"70","author":"Treede","year":"2008","journal-title":"Neurology"},{"key":"2022051610564509600_B9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1161\/01.HYP.29.1.30","article-title":"Nocturnal blood pressure fall on ambulatory monitoring in a large international database. The \u201cAd Hoc\u201d Working Group","volume":"29","author":"Staessen","year":"1997","journal-title":"Hypertension"},{"key":"2022051610564509600_B10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.7326\/0003-4819-131-7-199910050-00002","article-title":"Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome","volume":"131","author":"Netzer","year":"1999","journal-title":"Ann Intern Med"},{"key":"2022051610564509600_B11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.sleep.2004.07.006","article-title":"Psychometric properties of the Medical Outcomes Study Sleep measure","volume":"6","author":"Hays","year":"2005","journal-title":"Sleep Med"},{"key":"2022051610564509600_B12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1207\/s15327752jpa6703_13","article-title":"Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients","volume":"67","author":"Beck","year":"1996","journal-title":"J Pers Assess"},{"key":"2022051610564509600_B13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejpain.2010.06.011","article-title":"Clinical correlates of painful diabetic neuropathy and relationship of neuropathic pain with sensorimotor and autonomic nerve function","volume":"15","author":"Spallone","year":"2011","journal-title":"Eur J Pain"},{"key":"2022051610564509600_B14","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.2337\/dc09-2314","article-title":"Painful diabetic neuropathy is associated with greater autonomic dysfunction than painless diabetic neuropathy","volume":"33","author":"Gandhi","year":"2010","journal-title":"Diabetes Care"},{"key":"2022051610564509600_B15","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/sleep\/27.6.1097","article-title":"Sleep quality and blood pressure dipping in normal adults","volume":"27","author":"Loredo","year":"2004","journal-title":"Sleep"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/37\/9\/2640\/487908\/2640.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/37\/9\/2640\/487908\/2640.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T10:57:07Z","timestamp":1652698627000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/37\/9\/2640\/28998\/A-Novel-Association-Between-Nondipping-and-Painful"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,7]]},"references-count":15,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,8,7]]},"published-print":{"date-parts":[[2014,9,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc14-0528","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,7]]}}}