{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:24:51Z","timestamp":1790958291658,"version":"4.1.0"},"reference-count":24,"publisher":"American Diabetes Association","issue":"10","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Betatrophin, a newly identified hormone, has been recently characterized as a potent stimulator that increases the production and expansion of insulin-secreting \u03b2-cells in mice, but the physiological role of betatrophin remains poorly understood. This study measured for the first time serum betatrophin levels in newly diagnosed patients with type 2 diabetes (T2DM) and explored the correlations between its serum levels and various metabolic parameters in T2DM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>We analyzed the concentrations of betatrophin by ELISA in blood samples of 166 well-characterized individuals in whom anthropometric parameters, oral glucose tolerance test (OGTT), glycosylated hemoglobin, blood lipids, insulin sensitivity (1\/homeostasis model assesment of insulin resistance [1\/HOMA-IR] and Matsuda index [ISIM]), and insulin secretion were measured. The participants were divided into newly diagnosed T2DM patients (n = 83) and age-, sex- and BMI-matched healthy control subjects (n = 83).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Serum betatrophin levels were significantly higher in T2DM patients than in healthy control subjects (613.08 [422.19\u2013813.08] vs. 296.57 [196.53\u2013509.46] pg\/mL; P &amp;lt; 0.01). Serum betatrophin positively correlated with age, 2-h post-OGTT glucose (2hPG), and postprandial serum insulin (PSI), but negatively with 1\/HOMA-IR and ISIM in T2DM patients. In the control group, betatrophin was only positively associated with age. In T2DM subjects, multivariate regression analyses showed that age, 2hPG, and PSI were independent factors influencing serum betatrophin levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Circulating concentrations of betatrophin are significantly increased in T2DM patients. Our results suggest that betatrophin may play a role in the pathogenesis of T2DM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc14-0602","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T05:37:51Z","timestamp":1405402671000},"page":"2718-2722","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":147,"title":["Increased Circulating Levels of Betatrophin in Newly Diagnosed Type 2 Diabetic Patients"],"prefix":"10.2337","volume":"37","author":[{"given":"Hao","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiafei","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyun","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caoming","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyue","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2014,9,10]]},"reference":[{"key":"2022031221181640600_B1","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.2337\/db12-1464","article-title":"Microphthalmia transcription factor regulates pancreatic \u03b2-cell function","volume":"62","author":"Mazur","year":"2013","journal-title":"Diabetes"},{"key":"2022031221181640600_B2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cell.2013.04.008","article-title":"Betatrophin: a hormone that controls pancreatic \u03b2 cell proliferation","volume":"153","author":"Yi","year":"2013","journal-title":"Cell"},{"key":"2022031221181640600_B3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1097-2765(05)00015-8","article-title":"Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction","volume":"6","author":"Michael","year":"2000","journal-title":"Mol Cell"},{"key":"2022031221181640600_B4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.celrep.2013.01.007","article-title":"Liver-derived systemic factors drive \u03b2 cell hyperplasia in insulin-resistant states","volume":"3","author":"El Ouaamari","year":"2013","journal-title":"Cell Reports"},{"key":"2022031221181640600_B5","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc11-S062","article-title":"Diagnosis and classification of diabetes mellitus","volume":"34","author":"American Diabetes Association","year":"2011","journal-title":"Diabetes Care"},{"key":"2022031221181640600_B6","unstructured":"The Oxford Centre for Diabetes, Endocrinology, and Metabolism. 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