{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:25:09Z","timestamp":1782199509568,"version":"3.54.5"},"reference-count":40,"publisher":"American Diabetes Association","issue":"10","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"\n OBJECTIVE<\/jats:title>\n To determine whether an intensive lifestyle intervention (ILI) designed to sustain weight loss and improve physical fitness in overweight or obese persons with type 2 diabetes was associated with bone loss after 4 years of follow-up.<\/jats:p>\n <\/jats:sec>\n \n RESEARCH DESIGN AND METHODS<\/jats:title>\n This randomized controlled trial of intensive weight loss compared an ILI with a diabetes support and education (DSE) group among 1,309 overweight or obese subjects. Bone mineral density was assessed at baseline and after 1 year and 4 years of intervention.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n ILI was effective in producing significant weight loss (5.3% vs. 1.8% in ILI and DSE, respectively; P &lt; 0.01) and increased fitness (6.4% vs. \u22120.8%) at year 4. In men, ILI participants had a greater rate of bone loss during the first year (\u22121.66% vs. \u22120.09% per year in ILI and DSE, respectively). Differences between groups were diminished by one-half after 4 years (\u22120.88% vs. \u22120.05% per year in ILI and DSE, respectively) but remained significant (P &lt; 0.01). The difference in rate of hip bone loss between groups over 4 years was related to increased weight loss in ILI. Among women, the rate of bone loss did not differ between ILI and DSE after 4 years.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n A 4-year weight loss intervention was significantly associated with a modest increase in bone loss at the hip in men but not in women.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/dc14-0762","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T01:44:00Z","timestamp":1405993440000},"page":"2822-2829","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":48,"title":["The Look AHEAD Trial: Bone Loss at 4-Year Follow-up in Type 2 Diabetes"],"prefix":"10.2337","volume":"37","author":[{"given":"Edward W.","family":"Lipkin","sequence":"first","affiliation":[{"name":"Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, 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