{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:44:50Z","timestamp":1793814290245,"version":"4.6.1"},"reference-count":40,"publisher":"American Diabetes Association","issue":"1","funder":[{"name":"Fujian Province","award":["2009Y4001"],"award-info":[{"award-number":["2009Y4001"]}]},{"name":"Fujian Province","award":["2008J1006"],"award-info":[{"award-number":["2008J1006"]}]},{"name":"Fujian Province","award":["2010Y2006"],"award-info":[{"award-number":["2010Y2006"]}]},{"name":"Fujian Province","award":["2012YZ0001"],"award-info":[{"award-number":["2012YZ0001"]}]},{"DOI":"10.13039\/501100017675","name":"People\u2019s Liberation Army","doi-asserted-by":"crossref","award":["2010gxjs026"],"award-info":[{"award-number":["2010gxjs026"]}],"id":[{"id":"10.13039\/501100017675","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2012J01408"],"award-info":[{"award-number":["2012J01408"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001078","name":"Diabetes Research Institute Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001078","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To determine the safety and effects on insulin secretion of umbilical cord (UC) mesenchymal stromal cells (MSCs) plus autologous bone marrow mononuclear cell (aBM-MNC) stem cell transplantation (SCT) without immunotherapy in established type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>Between January 2009 and December 2010, 42 patients with T1D were randomized (n = 21\/group) to either SCT (1.1 \u00d7 106\/kg UC-MSC, 106.8 \u00d7 106\/kg aBM-MNC through supraselective pancreatic artery cannulation) or standard care (control). Patients were followed for 1 year at 3-month intervals. The primary end point was C-peptide area under the curve (AUCC-Pep) during an oral glucose tolerance test at 1 year. Additional end points were safety and tolerability of the procedure, metabolic control, and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The treatment was well tolerated. At 1 year, metabolic measures improved in treated patients: AUCC-Pep increased 105.7% (6.6 \u00b1 6.1 to 13.6 \u00b1 8.1 pmol\/mL\/180 min, P = 0.00012) in 20 of 21 responders, whereas it decreased 7.7% in control subjects (8.4 \u00b1 6.8 to 7.7 \u00b1 4.5 pmol\/mL\/180 min, P = 0.013 vs. SCT); insulin area under the curve increased 49.3% (1,477.8 \u00b1 1,012.8 to 2,205.5 \u00b1 1,194.0 mmol\/mL\/180 min, P = 0.01), whereas it decreased 5.7% in control subjects (1,517.7 \u00b1 630.2 to 1,431.7 \u00b1 441.6 mmol\/mL\/180 min, P = 0.027 vs. SCT). HbA1c decreased 12.6% (8.6 \u00b1 0.81% [70.0 \u00b1 7.1 mmol\/mol] to 7.5 \u00b1 1.0% [58.0 \u00b1 8.6 mmol\/mol], P &amp;lt; 0.01) in the treated group, whereas it increased 1.2% in the control group (8.7 \u00b1 0.9% [72.0 \u00b1 7.5 mmol\/mol] to 8.8 \u00b1 0.9% [73 \u00b1 7.5 mmol\/mol], P &amp;lt; 0.01 vs. SCT). Fasting glycemia decreased 24.4% (200.0 \u00b1 51.1 to 151.2 \u00b1 22.1 mg\/dL, P &amp;lt; 0.002) and 4.3% in control subjects (192.4 \u00b1 35.3 to 184.2 \u00b1 34.3 mg\/dL, P &amp;lt; 0.042). Daily insulin requirements decreased 29.2% in only the treated group (0.9 \u00b1 0.2 to 0.6 \u00b1 0.2 IU\/day\/kg, P = 0.001), with no change found in control subjects (0.9 \u00b1 0.2 to 0.9 \u00b1 0.2 IU\/day\/kg, P &amp;lt; 0.01 vs. SCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Transplantation of UC-MSC and aBM-MNC was safe and associated with moderate improvement of metabolic measures in patients with established T1D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc15-0171","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T23:09:57Z","timestamp":1449011397000},"page":"149-157","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":171,"title":["Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes: A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion"],"prefix":"10.2337","volume":"39","author":[{"given":"Jinquan","family":"Cai","sequence":"first","affiliation":[{"name":"Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixian","family":"Wu","sequence":"additional","affiliation":[{"name":"Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumin","family":"Xu","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute, Cell Transplant Center, University of Miami, Miami, FL"},{"name":"Diabetes Research Institute Federation, Hollywood, FL"},{"name":"The Cure Alliance, Miami, FL"},{"name":"Department of Surgery, University of Miami Miller School of Medicine, Miami, 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