{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T01:04:47Z","timestamp":1762045487736,"version":"3.37.3"},"reference-count":30,"publisher":"American Diabetes Association","issue":"10","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":238,"URL":"http:\/\/www.diabetesjournals.org\/site\/license"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201300025C","HHSN268201300026C","HHSN268201300027C","HHSN268201300028C","HHSN268201300029C","HHSN268200900041C","1RO1-HL53560\u201301A1","R01-HL-078972"],"award-info":[{"award-number":["HHSN268201300025C","HHSN268201300026C","HHSN268201300027C","HHSN268201300028C","HHSN268201300029C","HHSN268200900041C","1RO1-HL53560\u201301A1","R01-HL-078972"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG0005","P30 AG024827"],"award-info":[{"award-number":["AG0005","P30 AG024827"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Prolonged sedentary time (ST) might be contributing to the diabetes epidemic, but most studies have been cross-sectional and few have objectively measured ST. The purpose of this study was to evaluate cross-sectional and 5-year longitudinal relationships between ST and metabolic parameters and outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>This was an analysis of 2,027 Coronary Artery Risk Development in Young Adults (CARDIA) study participants (aged 38\u201350 years, 57% female, and mean BMI of 29.0 \u00b1 7.0 kg\/m2) with accelerometry data (\u22654 days with \u226510 h\/day) measured at the year 20 follow-up exam (2005\u20132006). Metabolic variables (fasting glucose, fasting insulin, 2-h postchallenge glucose, HOMA of insulin resistance [HOMA-IR], and HbA1c) and outcomes (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], prediabetes by HbA1c, and diabetes) were assessed concurrently and 5 years later.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Average ST was 8.1 \u00b1 1.7 h\/day or 55 \u00b1 10% of wear time. Each additional hour per day of ST was cross-sectionally associated with a 3% higher fasting insulin and HOMA-IR (both P &amp;lt; 0.01) but not 5-year changes in metabolic parameters. Having \u226510 h\/day vs. &amp;lt;6 h\/day of ST was associated with an odds ratio (OR) = 2.74 (95% CI 1.13, 6.62) for IGT and an OR = 3.80 (95% CI 1.39, 10.35) for diabetes. ST was not associated with prevalent IFG, prevalent prediabetes by HbA1c, or 5-year incidence of any metabolic outcomes (all P &amp;gt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>ST was independently related to insulin, HOMA-IR, and prevalent diabetes and IGT but did not predict 5-year changes in metabolic parameters or incidence of metabolic outcomes. These results suggest that higher ST may not be a risk factor for future metabolic outcomes, but more research with repeated ST measurement and longer follow-up is needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc15-0226","type":"journal-article","created":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T02:55:23Z","timestamp":1436410523000},"page":"1835-1843","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":41,"title":["Cross-sectional and Longitudinal Associations Between Objectively Measured Sedentary Time and Metabolic Disease: The Coronary Artery Risk Development in Young Adults (CARDIA) Study"],"prefix":"10.2337","volume":"38","author":[{"given":"Bethany","family":"Barone Gibbs","sequence":"first","affiliation":[{"name":"Department of Health and Physical Activity, University of Pittsburgh, Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelley","family":"Pettee Gabriel","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, School of Public Health Austin Regional Campus, Austin, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared P.","family":"Reis","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Jakicic","sequence":"additional","affiliation":[{"name":"Department of Health and Physical Activity, University of Pittsburgh, Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes R.","family":"Carnethon","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, 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