{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:47:29Z","timestamp":1785577649642,"version":"3.56.0"},"reference-count":17,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":237,"URL":"http:\/\/www.diabetesjournals.org\/site\/license"}],"funder":[{"name":"Leroy Schecter Foundation"},{"name":"Irma T. Hirschl Scholar Award"},{"DOI":"10.13039\/100000988","name":"Helen Bader Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000988","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 AG05138"],"award-info":[{"award-number":["P50 AG05138"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG034087"],"award-info":[{"award-number":["R01 AG034087"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AG043878"],"award-info":[{"award-number":["R21 AG043878"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000965","name":"American Federation for Aging Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000965","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>We assessed whether the apolipoprotein \u03b54 (APOE4) genotype affects the relationship of variability in long-term glycemic control (measured by HbA1c SD of multiple measurements) with white matter hyperintensities (WMHs) in elderly patients with type 2 diabetes (T2D).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>WMH volume was generated from structural T1 and fluid-attenuated inversion recovery MRI in each subject. The analysis included 124 subjects; 27 (21.8%) had one or more APOE4 alleles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>HbA1c variability was associated with significantly higher WMH in APOE4 carriers (r = 0.47, P = 0.03), controlling for age, sex, mean HbA1c, number of follow-up years, and a composite of cardiovascular risk factors, but not in noncarriers (r = \u22120.04, P = 0.71; P for interaction = 0.050).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The results suggest that the APOE4 genotype affects the relationship of long-term glycemic control with WMH load so that APOE4 carriers may be more vulnerable to the insults of poor control.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc15-2331","type":"journal-article","created":{"date-parts":[[2016,4,9]],"date-time":"2016-04-09T04:04:33Z","timestamp":1460174673000},"page":"1056-1059","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":33,"title":["Long-term Variability in Glycemic Control Is Associated With White Matter Hyperintensities in APOE4 Genotype Carriers With Type 2 Diabetes"],"prefix":"10.2337","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2216-7357","authenticated-orcid":false,"given":"Abigail","family":"Livny","sequence":"first","affiliation":[{"name":"Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel"},{"name":"Josef Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-3322","authenticated-orcid":false,"given":"Ramit","family":"Ravona-Springer","sequence":"additional","affiliation":[{"name":"Josef Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel"},{"name":"Memory Clinic, Sheba Medical Center, Tel HaShomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2353-9933","authenticated-orcid":false,"given":"Anthony","family":"Heymann","sequence":"additional","affiliation":[{"name":"Maccabi Healthcare Services, Tel Aviv, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Priess","sequence":"additional","affiliation":[{"name":"Maccabi Healthcare Services, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammar","family":"Kushnir","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galia","family":"Tsarfaty","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leeron","family":"Rabinov","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reut","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadass","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Josef Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzik","family":"Cooper","sequence":"additional","affiliation":[{"name":"Josef Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel"},{"name":"School of Psychology, Interdisciplinary Center Herzliya, Herzliya, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"Josef Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5899-128X","authenticated-orcid":false,"given":"Jeremy","family":"Silverman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY"},{"name":"James J. 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