{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:50:52Z","timestamp":1760709052360,"version":"3.37.3"},"reference-count":14,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":219,"URL":"http:\/\/www.diabetesjournals.org\/site\/license"}],"funder":[{"DOI":"10.13039\/100008871","name":"JDRF","doi-asserted-by":"publisher","award":["4\/2005\/1327"],"award-info":[{"award-number":["4\/2005\/1327"]}],"id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical research foundation of the University Hospital Leuven"},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"name":"W. Gepts fund"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>We investigated whether changes in islet autoantibody profile and presence of HLA risk markers, reported to predict rapid \u03b2-cell loss in pre\u2013type 1 diabetes, associate with poor functional outcome in islet allograft recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESEARCH DESIGN AND METHODS<\/jats:title><jats:p>Forty-one patients received \u22652.3 million \u03b2-cells\/kg body wt in one to two intraportal implantations. Outcome after 6\u201318 months was assessed by C-peptide (random and stimulated), insulin dose, and HbA1c.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Patients carrying HLA-A*24-positive or experiencing a significant autoantibody surge within 6 months after the first transplantation (n = 19) had lower C-peptide levels (P \u2264 0.003) and higher insulin needs (P &amp;lt; 0.001) despite higher HbA1c levels (P \u2264 0.018). They became less often insulin independent (16% vs. 68%, P = 0.002) and remained less often C-peptide positive (47% vs. 100%, P &amp;lt; 0.001) than recipients lacking both risk factors. HLA-A*24 positivity or an autoantibody surge predicted insulin dependence (P = 0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>HLA-A*24 and early autoantibody surge after islet implantation associate with poor functional graft outcome.<\/jats:p><\/jats:sec>","DOI":"10.2337\/dc15-2768","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T04:53:46Z","timestamp":1461732826000},"page":"1060-1064","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":12,"title":["<i>HLA-A*24<\/i>Carrier Status and Autoantibody Surges Posttransplantation Associate With Poor Functional Outcome in Recipients of an Islet Allograft"],"prefix":"10.2337","volume":"39","author":[{"given":"Simke","family":"Demeester","sequence":"first","affiliation":[{"name":"Diabetes Research Center, Brussels Free University, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Else M.","family":"Balke","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Brussels Free University, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart J.","family":"Van der Auwera","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Brussels Free University, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter","family":"Gillard","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Brussels Free University, Brussels, Belgium"},{"name":"Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hilbrands","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Brussels Free University, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DaHae","family":"Lee","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Brussels Free University, Brussels, Belgium"},{"name":"Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursule","family":"Van de Velde","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Brussels Free University, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhidong","family":"Ling","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Brussels Free University, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart O.","family":"Roep","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the 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