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In addition, the value of the wGRS in pediatric prediction of type 2 diabetes was examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of the 2,298 participants, 484 (21.8%) and 79 (3.4%) had IFG or type 2 diabetes in adulthood, respectively. Adjusting for age, sex, baseline BMI, parental diabetes, mother\u2019s BMI, fasting insulin concentration, systolic blood pressure, and smoking status, wGRS was associated with an increased risk of IFG (odds ratio 1.64 [95% CI 1.33\u20132.01] per unit increase in the wGRS) and type 2 diabetes (2.22 [1.43\u20133.44]). Incorporating wGRS into pediatric risk models improved model discrimination and reclassification properties. Area under the receiver operating curve improved for IFG (from 0.678 to 0.691, P = 0.015), combined IFG and type 2 diabetes outcome (from 0.678 to 0.692, P = 0.007), and type 2 diabetes (from 0.728 to 0.749, P = 0.158). The net reclassification improvement and integrated discrimination improvement were significant for all outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>A multifactorial approach combining genetic and clinical risk factors may be useful in identifying children at high risk for adult IFG and type 2 diabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc16-0167","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T02:23:25Z","timestamp":1465871005000},"page":"1393-1399","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":17,"title":["Role of Conventional Childhood Risk Factors Versus Genetic Risk in the Development of Type 2 Diabetes and Impaired Fasting Glucose in Adulthood: The Cardiovascular Risk in Young Finns Study"],"prefix":"10.2337","volume":"39","author":[{"given":"Niina","family":"Pitk\u00e4nen","sequence":"first","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Juonala","sequence":"additional","affiliation":[{"name":"Division of Medicine, Turku University Hospital, Turku, Finland"},{"name":"Department of Medicine, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapani","family":"R\u00f6nnemaa","sequence":"additional","affiliation":[{"name":"Division of Medicine, Turku University Hospital, Turku, Finland"},{"name":"Department of Medicine, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Sabin","sequence":"additional","affiliation":[{"name":"Murdoch Childrens Research Institute, Royal Children\u2019s 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