{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:31:42Z","timestamp":1790379102825,"version":"4.1.0"},"reference-count":40,"publisher":"American Diabetes Association","issue":"7","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":173,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To define the threshold for excess glucose variability (GV), one of the main features of dysglycemia in diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>A total of 376 persons with diabetes investigated at the University Hospital of Montpellier (Montpellier, France) underwent continuous glucose monitoring. Participants with type 2 diabetes were divided into several groups\u2014groups 1, 2a, 2b, and 3 (n = 82, 28, 65, and 79, respectively)\u2014according to treatment: 1) diet and\/or insulin sensitizers alone; 2) oral therapy including an insulinotropic agent, dipeptidyl peptidase 4 inhibitors (group 2a) or sulfonylureas (group 2b); or 3) insulin. Group 4 included 122 persons with type 1 diabetes. Percentage coefficient of variation for glucose (%CV = [(SD of glucose)\/(mean glucose)] \u00d7 100) and frequencies of hypoglycemia (interstitial glucose &amp;lt;56 mg\/dL [3.1 mmol\/L]) were computed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Percentages of CV (median [interquartile range]; %) increased significantly (P &amp;lt; 0.0001) from group 1 (18.1 [15.2\u201323.9]) to group 4 (37.2 [31.0\u201342.3]). In group 1, the upper limit of %CV, which served as reference for defining excess GV, was 36%. Percentages of patients with %CVs above this threshold in groups 2a, 2b, 3, and 4 were 0, 12.3, 19.0, and 55.7%, respectively. Hypoglycemia was more frequent in group 2b (P &amp;lt; 0.01) and groups 3 and 4 (P &amp;lt; 0.0001) when subjects with a %CV &amp;gt;36% were compared with those with %CV \u226436%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>A %CV of 36% appears to be a suitable threshold to distinguish between stable and unstable glycemia in diabetes because beyond this limit, the frequency of hypoglycemia is significantly increased, especially in insulin-treated subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc16-1769","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T21:30:27Z","timestamp":1483133427000},"page":"832-838","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":349,"title":["Toward Defining the Threshold Between Low and High Glucose Variability in 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes, and Nutrition, Montpellier University Hospital, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Molinari","sequence":"additional","affiliation":[{"name":"Department of Statistics and Epidemiology, UMR 5149, Montpellier University Hospital, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Owens","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Swansea University, Swansea, Wales, 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