{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:22:03Z","timestamp":1790169723755,"version":"4.1.0"},"reference-count":31,"publisher":"American Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"name":"French Programme Hospitalier de Recherche Clinique"},{"DOI":"10.13039\/501100008966","name":"Francophone Society for Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008966","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck Serono","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>The GERODIAB study is a multicenter prospective observational study performed over 5 years in French patients aged 70 years or above with type 2 diabetes. This report deals with their cardiovascular complications and their relationship with survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Consecutive patients (n = 987, median age = 77 years) were included from 56 diabetes centers over 1 year. Individual characteristics, history and complications of diabetes, geriatric factors, and clinical and biological parameters were recorded. Survival was analyzed using the Kaplan-Meier method and proportional hazards regression models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The frequency of cardiovascular complications increased from 47% at inclusion to 67% at 5 years. The most frequent complications were coronary heart disease (increasing from 30% to 41%) and vascular disease of the lower limbs (25% to 35%) and of the cerebral vessels (15% to 26%). Heart failure was less common, but its frequency doubled during the follow-up (9% to 20%). It was strongly associated with poor survival (P &amp;lt; 0.0001), as was vascular disease of the lower limbs (P = 0.0004), whereas coronary heart disease (P = 0.0056) and vascular disease of cerebral vessels (P = 0.026) had mild associations. Amputation (P &amp;lt; 0.0001) and foot wounds (P &amp;lt; 0.0001) were strongly associated with survival. In multivariate models, heart failure was the strongest predictor of poor survival (hazard ratio [HR] 1.96 [95% CI 1.45\u20132.64]; P &amp;lt; 0.0001). It remained significant when other factors were considered simultaneously (HR 1.92 [95% CI 1.43\u20132.58]; P &amp;lt; 0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Cardiovascular complications are associated with poor survival in elderly patients with type 2 diabetes, especially heart failure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc17-1437","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T01:25:34Z","timestamp":1510104334000},"page":"156-162","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":32,"title":["Cardiovascular Complications Over 5 Years and Their Association With Survival in the GERODIAB Cohort of Elderly French Patients With Type 2 Diabetes"],"prefix":"10.2337","volume":"41","clinical-trial-number":[{"clinical-trial-number":"nct01282060","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Bernard","family":"Bauduceau","sequence":"first","affiliation":[{"name":"Endocrinology, B\u00e9gin Hospital, Saint Mand\u00e9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1957-3477","authenticated-orcid":false,"given":"Jean-Pierre","family":"Le Floch","sequence":"additional","affiliation":[{"name":"Diabetology-Endocrinology, Villecresnes Medical Hospital, Villecresnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Halimi","sequence":"additional","affiliation":[{"name":"Diabetology, Endocrinology, Grenoble Alpes University, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Verny","sequence":"additional","affiliation":[{"name":"Gerontology, Bic\u00eatre University Hospital, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Doucet","sequence":"additional","affiliation":[{"name":"Internal Medicine, Geriatrics and Therapeutics, Saint Julien Hospital, Rouen University Hospital, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the SFD\/SFGG Intergroup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"2022031301241614800_B1","unstructured":"Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States [Internet], 2014. Atlanta, Centers for Disease Control and Prevention. Available from www.cdc.gov\/diabetes\/data\/statistics\/2014statisticsreport.html. 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Description of the population at inclusion","volume":"38","author":"Doucet","year":"2012","journal-title":"Diabetes Metab"},{"key":"2022031301241614800_B10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.2337\/dc13-1540","article-title":"Cardiovascular events and geriatric scale scores in elderly (70 years old and above) type 2 diabetic patients at inclusion in the GERODIAB cohort","volume":"37","author":"Bauduceau","year":"2014","journal-title":"Diabetes Care"},{"key":"2022031301241614800_B11","first-page":"S99","article-title":"Older adults","volume":"40","author":"American Diabetes Association","year":"2017","journal-title":"Sec. 11. In Standards of Medical Care in Diabetes\u20142017. Diabetes Care"},{"key":"2022031301241614800_B12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00125-014-3460-0","article-title":"Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. 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