{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:53:20Z","timestamp":1792482800769,"version":"4.5.0"},"reference-count":46,"publisher":"American Diabetes Association","issue":"2","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1DP3-DK-101120-01"],"award-info":[{"award-number":["1DP3-DK-101120-01"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001583","name":"Diabetes Action Research and Education Foundation","doi-asserted-by":"crossref","award":["00108316"],"award-info":[{"award-number":["00108316"]}],"id":[{"id":"10.13039\/100001583","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1-TR-000064"],"award-info":[{"award-number":["UL1-TR-000064"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1-TR-001427"],"award-info":[{"award-number":["UL1-TR-001427"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Pancreas size is reduced in patients at type 1 diabetes onset and in autoantibody (AAB)-positive donors without diabetes. We sought to determine whether pancreas volume (PV) imaging could improve understanding of the loss of pancreas size in first-degree relatives (FDRs) of patients with type 1 diabetes. We also examined relationships among PV, AAB status, and endocrine and exocrine functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study that included five groups: AAB\u2212 control subjects (no diabetes and no first- or second-degree relatives with type 1 diabetes) (N = 49), AAB\u2212 FDRs (N = 61), AAB+ FDRs (N = 67 total: n = 31 with a single positive AAB [AAB+ single] and n = 36 with multiple positive AABs [AAB+ multiple]), and patients with recent-onset type 1 diabetes (&amp;lt;1 year) (N = 52). Fasting subjects underwent 1.5T pancreatic MRI, and PV and relative PV (RPV) (PV-to-BMI ratio) were analyzed between groups and for correlations with HbA1c, C-peptide, glucose, and trypsinogen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>All FDR groups had significantly lower RPV adjusted for BMI (RPVBMI) than control subjects (all P &amp;lt; 0.05). Patients with type 1 diabetes had lower RPVBMI than AAB\u2212 FDR (P &amp;lt; 0.0001) and AAB+ multiple (P \u2264 0.013) subjects. Transformed data indicated that trypsinogen levels were lowest in patients with type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This study demonstrates, for the first time, all FDRs having significantly smaller RPVBMI compared with AAB\u2212 control subjects. Furthermore, RPVBMI was significantly lower in patients with recent-onset type 1 diabetes than in the AAB\u2212 FDR and AAB+ multiple groups. As such, RPVBMI may be a novel noninvasive biomarker for predicting progression through stages of type 1 diabetes risk. This study highlights the potential paracrine relationships between the exocrine and endocrine pancreas in progression to type 1 diabetes in subjects at risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc18-1512","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T20:12:24Z","timestamp":1544818344000},"page":"281-287","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":104,"title":["Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes"],"prefix":"10.2337","volume":"42","clinical-trial-number":[{"clinical-trial-number":"nct02234947","registry":"10.18810\/clinical-trials-gov","type":"results"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6878-1235","authenticated-orcid":false,"given":"Martha L.","family":"Campbell-Thompson","sequence":"first","affiliation":[{"name":"Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Filipp","sequence":"additional","affiliation":[{"name":"Health Outcomes and Biomedical Informatics, Institute for Child Health Policy, College of Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Grajo","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bimota","family":"Nambam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Beegle","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine, University of 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