{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:11:49Z","timestamp":1766049109343,"version":"3.37.3"},"reference-count":47,"publisher":"American Diabetes Association","issue":"4","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["IWT.150199"],"award-info":[{"award-number":["IWT.150199"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["C32\/17\/049"],"award-info":[{"award-number":["C32\/17\/049"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>The kinetics and risk factors of diabetic nephropathy after kidney transplantation remain unclear. This study investigated the posttransplant occurrence of diabetic nephropathy and the contribution of posttransplant glycemic control.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>We performed a single-center prospective cohort study of 953 renal allograft recipients and 3,458 protocol-specified renal allograft biopsy specimens up to 5 years after transplantation. The effects of pretransplant diabetes and glycemic control (glycated hemoglobin levels) on the posttransplant histology were studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Before transplantation, diabetes was present in 164 (17.2%) renal allograft recipients, primarily type 2 (n = 146 [89.0%]). Despite intensive glycemic control (glycated hemoglobin 7.00 \u00b1 1.34% [53 \u00b1 14.6 mmol\/mol], 6.90 \u00b1 1.22% [52 \u00b1 13.3 mmol\/mol], and 7.10 \u00b1 1.13% [54 \u00b1 12.4 mmol\/mol], at 1, 2, and 5 years after transplantation), mesangial matrix expansion reached a cumulative incidence of 47.7% by 5 years in the pretransplant diabetes group versus 27.1% in patients without diabetes, corresponding to a hazard ratio of 1.55 (95% CI 1.07\u20132.26; P = 0.005). Mesangial matrix expansion was not specific for diabetic nephropathy and associated independently with increasing age. Pretransplant diabetes was associated with posttransplant proteinuria but not with estimated glomerular filtration rate, graft failure, or any other structural changes of the glomerular, vascular, or tubulointerstitial renal compartments. The occurrence of diabetic nephropathy was independent of posttransplant glycated hemoglobin levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Mesangial matrix expansion, an early indicator of diabetic nephropathy, can occur rapidly in patients with diabetes before transplantation, despite intensive glycemic control. Prevention of diabetic nephropathy requires more than pursuing low levels of glycated hemoglobin.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc18-1936","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T19:55:22Z","timestamp":1550174122000},"page":"625-634","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":20,"title":["Occurrence of Diabetic Nephropathy After Renal Transplantation Despite Intensive Glycemic Control: An Observational Cohort Study"],"prefix":"10.2337","volume":"42","author":[{"given":"Maarten","family":"Coemans","sequence":"first","affiliation":[{"name":"Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium"},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium"},{"name":"Leuven Biostatistics and Statistical Bioinformatics Centre, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabet","family":"Van Loon","sequence":"additional","affiliation":[{"name":"Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium"},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Lerut","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology, KU Leuven, Leuven, Belgium"},{"name":"Department of Pathology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9111-4561","authenticated-orcid":false,"given":"Pieter","family":"Gillard","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium"},{"name":"Department of Diabetes and Endocrinology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Sprangers","sequence":"additional","affiliation":[{"name":"Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium"},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Senev","sequence":"additional","affiliation":[{"name":"Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium"},{"name":"Histocompatibility and Immunogenetic Laboratory, Red Cross Flanders, Mechelen, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Paule","family":"Emonds","sequence":"additional","affiliation":[{"name":"Histocompatibility and Immunogenetic Laboratory, Red Cross Flanders, Mechelen, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Van Keer","sequence":"additional","affiliation":[{"name":"Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasper","family":"Callemeyn","sequence":"additional","affiliation":[{"name":"Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium"},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbeth","family":"Dani\u00ebls","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Sichien","sequence":"additional","affiliation":[{"name":"Leuven Biostatistics and Statistical Bioinformatics Centre, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert","family":"Verbeke","sequence":"additional","affiliation":[{"name":"Leuven Biostatistics and Statistical Bioinformatics Centre, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Kuypers","sequence":"additional","affiliation":[{"name":"Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium"},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6099-2406","authenticated-orcid":false,"given":"Chantal","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium"},{"name":"Department of Diabetes and Endocrinology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-0792","authenticated-orcid":false,"given":"Maarten","family":"Naesens","sequence":"additional","affiliation":[{"name":"Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium"},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2019,2,14]]},"reference":[{"key":"2022031300015126200_B1","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"2022031300015126200_B2","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1172\/JCI111523","article-title":"Structural-functional relationships in diabetic nephropathy","volume":"74","author":"Mauer","year":"1984","journal-title":"J Clin Invest"},{"key":"2022031300015126200_B3","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1111\/j.1523-1755.2004.00988.x","article-title":"Diabetic nephropathy: linking histology, cell biology, and genetics","volume":"66","author":"Adler","year":"2004","journal-title":"Kidney Int"},{"key":"2022031300015126200_B4","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1681\/ASN.2016060666","article-title":"Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment","volume":"28","author":"Tonneijck","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"2022031300015126200_B5","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.2337\/diabetes.54.7.2164","article-title":"The early natural history of nephropathy in type 1 diabetes: III. Predictors of 5-year urinary albumin excretion rate patterns in initially normoalbuminuric patients","volume":"54","author":"Steinke","year":"2005","journal-title":"Diabetes"},{"key":"2022031300015126200_B6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1056\/NEJMoa0808400","article-title":"Renal and retinal effects of enalapril and losartan in type 1 diabetes","volume":"361","author":"Mauer","year":"2009","journal-title":"N Engl J Med"},{"key":"2022031300015126200_B7","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1001\/archinternmed.2011.2230","article-title":"Role of intensive glucose control in development of renal end points in type 2 diabetes mellitus: systematic review and meta-analysis intensive glucose control in type 2 diabetes","volume":"172","author":"Coca","year":"2012","journal-title":"Arch Intern Med"},{"key":"2022031300015126200_B8","first-page":"1","article-title":"European best practice guidelines for renal transplantation (part 1)","volume":"15","author":"EBPG (European Expert Group on Renal Transplantation)","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"2022031300015126200_B9","doi-asserted-by":"crossref","first-page":"i6158","DOI":"10.1136\/bmj.i6158","article-title":"Renal transplantation in adults","volume":"355","author":"Nieto","year":"2016","journal-title":"BMJ"},{"key":"2022031300015126200_B10","doi-asserted-by":"crossref","first-page":"948","DOI":"10.2337\/diab.32.10.948","article-title":"The development of lesions in the glomerular basement membrane and mesangium after transplantation of normal kidneys to diabetic patients","volume":"32","author":"Mauer","year":"1983","journal-title":"Diabetes"},{"key":"2022031300015126200_B11","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/BF00400997","article-title":"Kidney transplantation in type 1 (insulin-dependent) diabetic patients. Early glomerulopathy","volume":"34","author":"Osterby","year":"1991","journal-title":"Diabetologia"},{"key":"2022031300015126200_B12","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1001\/jama.1994.03520080042041","article-title":"Effect of glycemic control on early diabetic renal lesions. A 5-year randomized controlled clinical trial of insulin-dependent diabetic kidney transplant recipients","volume":"272","author":"Barbosa","year":"1994","journal-title":"JAMA"},{"key":"2022031300015126200_B13","first-page":"2290","article-title":"Recurrent diabetic nephropathy in renal allografts placed in diabetic patients and protective effect of simultaneous pancreatic transplantation","volume":"19","author":"Bohman","year":"1987","journal-title":"Transplant Proc"},{"key":"2022031300015126200_B14","doi-asserted-by":"crossref","first-page":"516","DOI":"10.2337\/diab.38.4.516","article-title":"Long-term study of normal kidneys transplanted into patients with type I diabetes","volume":"38","author":"Mauer","year":"1989","journal-title":"Diabetes"},{"key":"2022031300015126200_B15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00007890-200301150-00012","article-title":"Recurrent and de novo diabetic nephropathy in renal allografts","volume":"75","author":"Bhalla","year":"2003","journal-title":"Transplantation"},{"key":"2022031300015126200_B16","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/ajt.14431","article-title":"Renal allograft histology at 10 years after transplantation in the tacrolimus era: evidence of pervasive chronic injury","volume":"18","author":"Stegall","year":"2018","journal-title":"Am J Transplant"},{"key":"2022031300015126200_B17","first-page":"A0828","article-title":"A simplified equation to predict glomerular filtration rate from serum creatinine","volume":"11","author":"Levey","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"2022031300015126200_B18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/ajt.14107","article-title":"The Banff 2015 kidney meeting report: current challenges in rejection classification and prospects for adopting molecular pathology","volume":"17","author":"Loupy","year":"2017","journal-title":"Am J Transplant"},{"key":"2022031300015126200_B19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/ajt.14625","article-title":"The Banff 2017 kidney meeting report: revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials","volume":"18","author":"Haas","year":"2018","journal-title":"Am J Transplant"},{"key":"2022031300015126200_B20","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1080\/01621459.1997.10474049","article-title":"A hybrid algorithm for computation of the nonparametric maximum likelihood estimator from censored data","volume":"92","author":"Wellner","year":"1997","journal-title":"J Am Stat Assoc"},{"key":"2022031300015126200_B21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v072.i07","article-title":"The R package JMbayes for fitting joint models for longitudinal and time-to-event data using MCMC","volume":"72","author":"Rizopoulos","year":"2016","journal-title":"J Stat Softw"},{"key":"2022031300015126200_B22","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/00007890-199609150-00016","article-title":"Diabetic nephropathy after renal transplantation. Clinical and pathologic features","volume":"62","author":"Hariharan","year":"1996","journal-title":"Transplantation"},{"key":"2022031300015126200_B23","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00007890-198901000-00024","article-title":"Long-term survival following kidney transplantation in 100 type I diabetic patients","volume":"47","author":"Najarian","year":"1989","journal-title":"Transplantation"},{"key":"2022031300015126200_B24","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1056\/NEJM197610212951703","article-title":"Development of diabetic vascular lesions in normal kidneys transplanted into patients with diabetes mellitus","volume":"295","author":"Mauer","year":"1976","journal-title":"N Engl J Med"},{"key":"2022031300015126200_B25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/ndt\/gfs583","article-title":"Novel views on new-onset diabetes after transplantation: development, prevention and treatment","volume":"28","author":"Hecking","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"2022031300015126200_B26","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/ncpendmet0894","article-title":"The pathogenesis of diabetic nephropathy","volume":"4","author":"Dronavalli","year":"2008","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"2022031300015126200_B27","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: a unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"key":"2022031300015126200_B28","doi-asserted-by":"crossref","first-page":"i6505","DOI":"10.1136\/bmj.i6505","article-title":"How to prevent the microvascular complications of type 2 diabetes beyond glucose control","volume":"356","author":"Valencia","year":"2017","journal-title":"BMJ"},{"key":"2022031300015126200_B29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1530\/JOE-16-0205","article-title":"PAPP-A in normal human mesangial cells: effect of inflammation and factors related to diabetic nephropathy","volume":"231","author":"Donegan","year":"2016","journal-title":"J Endocrinol"},{"key":"2022031300015126200_B30","doi-asserted-by":"crossref","first-page":"e100777","DOI":"10.1371\/journal.pone.0100777","article-title":"Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db\/db mice","volume":"9","author":"Terami","year":"2014","journal-title":"PLoS One"},{"key":"2022031300015126200_B31","doi-asserted-by":"crossref","first-page":"F194","DOI":"10.1152\/ajprenal.00520.2013","article-title":"SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice","volume":"306","author":"Vallon","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"2022031300015126200_B32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1053\/j.ajkd.2014.02.010","article-title":"Sodium\/glucose cotransporter 2 inhibitors and prevention of diabetic nephropathy: targeting the renal tubule in diabetes","volume":"64","author":"De Nicola","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"2022031300015126200_B33","doi-asserted-by":"crossref","first-page":"e00239","DOI":"10.1002\/prp2.239","article-title":"Inhibition of SGLT2 alleviates diabetic nephropathy by suppressing high glucose-induced oxidative stress in type 1 diabetic mice","volume":"4","author":"Hatanaka","year":"2016","journal-title":"Pharmacol Res Perspect"},{"key":"2022031300015126200_B34","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41581-018-0092-5","article-title":"A promising outlook for diabetic kidney disease","volume":"15","author":"Cooper","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"2022031300015126200_B35","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/ki.2008.319","article-title":"The aging kidney","volume":"74","author":"Zhou","year":"2008","journal-title":"Kidney Int"},{"key":"2022031300015126200_B36","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1046\/j.1523-1755.2003.00831.x","article-title":"Morphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation","volume":"63","author":"Hill","year":"2003","journal-title":"Kidney Int"},{"key":"2022031300015126200_B37","doi-asserted-by":"crossref","first-page":"F1563","DOI":"10.1152\/ajprenal.90302.2008","article-title":"Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy","volume":"295","author":"Verzola","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"2022031300015126200_B38","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.2337\/db14-1820","article-title":"Cellular senescence in type 2 diabetes: a therapeutic opportunity","volume":"64","author":"Palmer","year":"2015","journal-title":"Diabetes"},{"key":"2022031300015126200_B39","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/BF00253406","article-title":"Increased kidney size, glomerular filtration rate and renal plasma flow in short-term insulin-dependent diabetics","volume":"20","author":"Christiansen","year":"1981","journal-title":"Diabetologia"},{"key":"2022031300015126200_B40","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0002-9343(82)90490-9","article-title":"The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies","volume":"72","author":"Hostetter","year":"1982","journal-title":"Am J Med"},{"key":"2022031300015126200_B41","doi-asserted-by":"crossref","first-page":"5963","DOI":"10.1073\/pnas.82.17.5963","article-title":"Predominance of hemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy","volume":"82","author":"Zatz","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022031300015126200_B42","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1056\/NEJM199611283352203","article-title":"Development and progression of renal disease in Pima Indians with non-insulin-dependent diabetes mellitus","volume":"335","author":"Nelson","year":"1996","journal-title":"N Engl J Med"},{"key":"2022031300015126200_B43","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1111\/j.1523-1755.2005.00590.x","article-title":"The relationship between microalbuminuria and glomerular filtration rate in young type 1 diabetic subjects: the Oxford Regional Prospective Study","volume":"68","author":"Amin","year":"2005","journal-title":"Kidney Int"},{"key":"2022031300015126200_B44","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00125-009-1268-0","article-title":"Is hyperfiltration associated with the future risk of developing diabetic nephropathy? A meta-analysis","volume":"52","author":"Magee","year":"2009","journal-title":"Diabetologia"},{"key":"2022031300015126200_B45","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.2337\/dc11-2189","article-title":"Glomerular hyperfiltration and renal disease progression in type 2 diabetes","volume":"35","author":"Ruggenenti","year":"2012","journal-title":"Diabetes Care"},{"key":"2022031300015126200_B46","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/MED.0000000000000074","article-title":"Early diabetic nephropathy in type 1 diabetes: new insights","volume":"21","author":"Bjornstad","year":"2014","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"2022031300015126200_B47","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/ki.2013.47","article-title":"The GFR and GFR decline cannot be accurately estimated in type 2 diabetics","volume":"84","author":"Gaspari","year":"2013","journal-title":"Kidney Int"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/care.diabetesjournals.org\/syndication\/doi\/10.2337\/dc18-1936","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/42\/4\/625\/550092\/dc181936.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/42\/4\/625\/550092\/dc181936.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T22:02:31Z","timestamp":1647122551000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/42\/4\/625\/36054\/Occurrence-of-Diabetic-Nephropathy-After-Renal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,14]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,2,14]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc18-1936","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"type":"print","value":"0149-5992"},{"type":"electronic","value":"1935-5548"}],"subject":[],"published":{"date-parts":[[2019,2,14]]}}}