{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:12:05Z","timestamp":1790770325080,"version":"4.1.0"},"reference-count":15,"publisher":"American Diabetes Association","issue":"4","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Cutaneous adverse events (CAE) from FreeStyle Libre include allergic contact dermatitis (ACD) caused by the allergen isobornyl acrylate (IBOA). We aim to report CAE from this glucose sensor, ACD to IBOA in particular, and the outcome of using barrier films as a prevention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>A monocentric, retrospective review of medical files from adult and pediatric patients with diabetes using Freestyle Libre, in the period between December 2016 and April 2019, was performed with a focus on CAE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Fifty-seven of 1,036 patients with diabetes (5.5%) were referred to our dermatology department because of CAE from FreeStyle Libre. Thirty-nine of 1,036 (3.8%) had ACD due to IBOA. Only two patients, of whom one sensitized to IBOA, had a benefit from using barrier films.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>CAE occurred in 5.5% of FreeStyle Libre users, and 3.8% suffered from ACD due to IBOA. Barrier films had limited value in the prevention.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc19-1354","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T22:54:22Z","timestamp":1581634462000},"page":"918-920","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":43,"title":["Prevalence and Prevention of Contact Dermatitis Caused by FreeStyle Libre: A Monocentric Experience"],"prefix":"10.2337","volume":"43","author":[{"given":"Jeroen","family":"Pyl","sequence":"first","affiliation":[{"name":"Department of Dermatology, Antwerp University Hospital, Antwerp, Belgium"},{"name":"University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Dendooven","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Antwerp University Hospital, Antwerp, Belgium"},{"name":"University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ine","family":"Van Eekelen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Antwerp University Hospital, Antwerp, Belgium"},{"name":"University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"den Brinker","sequence":"additional","affiliation":[{"name":"University of Antwerp, Antwerp, Belgium"},{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Antwerp University Hospital, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Dotremont","sequence":"additional","affiliation":[{"name":"University of Antwerp, Antwerp, Belgium"},{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Antwerp University Hospital, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"France","sequence":"additional","affiliation":[{"name":"University of Antwerp, Antwerp, Belgium"},{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Antwerp University Hospital, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenn","family":"Foubert","sequence":"additional","affiliation":[{"name":"University of Antwerp, Antwerp, Belgium"},{"name":"Natural Products & Food Research and Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Pieters","sequence":"additional","affiliation":[{"name":"University of Antwerp, Antwerp, Belgium"},{"name":"Natural Products & Food Research and Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Antwerp University Hospital, Antwerp, Belgium"},{"name":"University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"De Block","sequence":"additional","affiliation":[{"name":"University of Antwerp, Antwerp, Belgium"},{"name":"Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-2887","authenticated-orcid":false,"given":"Olivier","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Antwerp University Hospital, Antwerp, Belgium"},{"name":"University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"2022031300353066000_B1","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/S0140-6736(16)31535-5","article-title":"Novel glucose-sensing technology and hypoglycaemia in type 1 diabetes: a multicentre, non-masked, randomised controlled trial","volume":"388","author":"Bolinder","year":"2016","journal-title":"Lancet"},{"key":"2022031300353066000_B2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/cod.12866","article-title":"Allergic contact dermatitis caused by isobornyl acrylate in Freestyle\u00ae Libre, a newly introduced glucose sensor","volume":"77","author":"Herman","year":"2017","journal-title":"Contact Dermatitis"},{"key":"2022031300353066000_B3","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1177\/1932296818762946","article-title":"Further evidence of severe allergic contact dermatitis from isobornyl acrylate while using a continuous glucose monitoring system","volume":"12","author":"Kamann","year":"2018","journal-title":"J Diabetes Sci Technol"},{"key":"2022031300353066000_B4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/cod.12995","article-title":"Allergic contact dermatitis caused by isobornyl acrylate in OmniPod, an innovative tubeless insulin pump","volume":"79","author":"Raison-Peyron","year":"2018","journal-title":"Contact Dermatitis"},{"key":"2022031300353066000_B5","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(17)32142-6","article-title":"FreeStyle Libre: contact irritation versus contact allergy","volume":"390","author":"Aerts","year":"2017","journal-title":"Lancet"},{"key":"2022031300353066000_B6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/cod.12432","article-title":"European Society of Contact Dermatitis guideline for diagnostic patch testing - recommendations on best practice","volume":"73","author":"Johansen","year":"2015","journal-title":"Contact Dermatitis"},{"key":"2022031300353066000_B7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/cod.13239","article-title":"A case of contact dermatitis caused by isobornyl acrylate in FreeStyle Libre: the usefulness of film-forming agents","volume":"81","author":"Shinkawa","year":"2019","journal-title":"Contact Dermatitis"},{"key":"2022031300353066000_B8","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/cod.13329","article-title":"Hydrocolloid blister plaster decreases allergic contact dermatitis caused by Freestyle Libre and isobornyl acrylate","volume":"81","author":"Kamann","year":"2019","journal-title":"Contact Dermatitis"},{"key":"2022031300353066000_B9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/cod.13248","article-title":"The Dexcom glucose monitoring system-an isobornyl acrylate-free alternative for diabetic 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Available from https:\/\/ansm.sante.fr\/S-informer\/Points-d-information-Points-d-information\/Mise-a-disposition-de-dispositifs-FreeStyle-Libre-avec-des-capteurs-modifies-Point-d-Information. Accessed 25 June 2019"},{"key":"2022031300353066000_B12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/cod.13337","article-title":"Allergic contact dermatitis caused by glucose sensors in type 1 diabetes patients","volume":"81","author":"Hyry","year":"2019","journal-title":"Contact Dermatitis"},{"key":"2022031300353066000_B13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/cod.13012","article-title":"Allergic contact dermatitis and diabetes medical devices: 2 clinical cases","volume":"79","author":"Passanisi","year":"2018","journal-title":"Contact Dermatitis"},{"key":"2022031300353066000_B14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/cod.13243","article-title":"N,N-dimethylacrylamide-a new sensitizer in the FreeStyle Libre glucose sensor","volume":"81","author":"Mowitz","year":"2019","journal-title":"Contact Dermatitis"},{"key":"2022031300353066000_B15","unstructured":"Medicines & Healthcare products Regulatory Agency. Medical Device Alert: MDA\/2019\/003: FreeStyle Libre Flash Glucose Sensor \u2013 Use of Barrier Methods to Reduce Skin Reactions to the Sensor Adhesive [Internet], 2019. Available from https:\/\/assets.publishing.service.gov.uk\/media\/5c4f35e1ed915d7d51fd5a35\/MDA-2019-003_Final13.pdf. Accessed 25 June 2019"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/43\/4\/918\/532359\/dc191354.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/43\/4\/918\/532359\/dc191354.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T03:54:08Z","timestamp":1647143648000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/43\/4\/918\/35724\/Prevalence-and-Prevention-of-Contact-Dermatitis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,13]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,2,13]]},"published-print":{"date-parts":[[2020,4,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc19-1354","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,13]]}}}