{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:31:08Z","timestamp":1778135468037,"version":"3.51.4"},"reference-count":15,"publisher":"American Diabetes Association","issue":"7","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":52,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Asymptomatic patients (8\u201345 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA1c and continuous glucose monitoring over 12 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9\u20138.2%, N = 1,298] vs. 4.7% [95% CI 3.4\u20135.9%, N = 1,089], P = 0.035) with lower rates of prior CD screening (6.9% vs. 44.2%, P &amp;lt; 0.0001). Fifty-one participants were randomized to a GFD (N = 27) or GCD (N = 24). No HbA1c differences were seen between the groups (+0.14%, 1.5 mmol\/mol; 95% CI \u22120.79 to 1.08; P = 0.76), although greater postprandial glucose increases (4-h +1.5 mmol\/L; 95% CI 0.4\u20132.7; P = 0.014) emerged with a GFD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc19-1944","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T03:19:41Z","timestamp":1588130381000},"page":"1553-1556","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":31,"title":["Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study"],"prefix":"10.2337","volume":"43","clinical-trial-number":[{"clinical-trial-number":"nct01566110","registry":"10.18810\/clinical-trials-gov","type":"results"},{"clinical-trial-number":"nct01566110","registry":"10.18810\/clinical-trials-gov","type":"results"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-3584","authenticated-orcid":false,"given":"Farid H.","family":"Mahmud","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3001-0213","authenticated-orcid":false,"given":"Antoine B.M.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kariym C.","family":"Joachim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Assor","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"McDonald","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, St. Joseph\u2019s Health Care, London Health Sciences Centre, Western University, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Saibil","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather A.","family":"Lochnan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Ottawa Hospital, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubin","family":"Punthakee","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amish","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Trillium Health Partners, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0497-645X","authenticated-orcid":false,"given":"Andrew","family":"Advani","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, St. Michael\u2019s Hospital, Toronto, Ontario, 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